[Plasma osmolarity and early weaning].
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Animals↗
Biomedical subjects
R Del Gado
Publications and source records attributed to R Del Gado.
Endocrine studies in children with myelomeningocele.
Pituitary-hypothalamic abnormalities due to impaired cerebrospinal fluid circulation have long been recognized. The aim of this study was to assess pituitary, thyroid, adrenal, and gonadal function in 46 prepubertal (22 M and 24 F) and 10 pubertal (4 M and 6 F) subjects with myelomeningocele (MMC). Basal serum levels of FT3, FT4, TSH, PRL, LH, FSH, T or E2, cortisol, 17-OH-P and DHEA-S were measured by routine radio-immunoassay methods. Twenty-two prepubertal patients had a TRH test for TSH and PRL evaluation, and eight underwent a GnRH test. Three patients presented with precocious puberty. Six subjects had modest elevations of serum TSH together with normal free thyroid hormone levels. In three cases, TSH responses to TRH were significantly exaggerated and prolonged: in two patients, TSH responses were delayed. The mean basal plasma FSH level in females with ventriculo-peritoneal shunt was significantly higher than in controls. In six cases FSH responses to GnRH were significantly higher than in controls. Both basal and stimulated PRL levels were elevated in patients with shunts; in patients without shunts, basal PRL was normal, but peak PRL levels following TRH stimulation were elevated. Our data show an abnormal hypothalamic-pituitary function in MMC subjects. These findings reinforce the importance of physical examination, hormonal evaluation and follow-up of pubertal development in patients with myelomeningocele.
Adolescent↗
Levamisole in children's idiopathic nephrotic syndrome.
13 children with frequently relapsing and/or steroid-dependent idiopathic nephrotic syndrome (INS) were treated with levamisole. 2.5 mg of levamisole per kilogram body weight twice a week (cycle A) were administered to all patients during 2-16 months (mean 5.8). A daily administration of the same dose of levamisole was given during 2-9 months (mean 4.9) to 8 patients who did not respond to cycle A (cycle B). A beneficial effect was observed in 6 cases: 4 with cycle A and 2 with cycle B. These patients suffered no relapse despite a significant decrease in the amount of prednisone administered or its discontinuation and they experienced a remission period of 7-29 months without prednisone administration. The side effects of the therapy turned out to be minimal both with cycle A and B. Levamisole may be effective in frequently relapsing and/or steroid-dependent INS with minimal side effects.
Child↗
[Glomerulonephritis caused by a shunt: description of a case].
The authors report a case of shunt-nephritis due to bacteremia from Stafilococcus albus. Kidney biopsy, comprehensive of IF study allowed to assess the diagnosis of a disease from immunocomplexes. The Authors stress the importance of a close follow-up of patients who carry liquoral shunt for an early recognition of symptoms of glomerulopathy.
Cerebrospinal Fluid Shunts↗
[Must renal biopsy be still performed in "lipoid nephrosis"? (author's transl)].
In 52 out of 272 children with one of the following diseases: nephrotic or nephritic syndrome, persistent humaturia and/or proteinuria, renal biopsy was performed on the basis of commonly accepted indications. 18 biopsies were from patients with a clinical picture of lipoid nephrosis and clinical course of "non responders" or "frequent relapsers" types. All of them showed the histologic pattern of minimal changes and had a value of Y index according to ISKCD greater than 0,85. Moreover all patients with minimal changes nephrotic syndrome had a Y index greater than 0.85. If these observations will be confirmed renal biopsy would not later be indicated in children with "lipoid nephrosis".
Biopsy↗