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Biomedical subjects

R DeLucia

Publications and source records attributed to R DeLucia.

28 records · Page 2Linked to original sources
PubMed1987

The effects of chronic treatment with fencamfamine on body weight, food intake and stereotyped behaviour in rats.

The effects of chronic treatment with fencamfamine (10.0 mg/kg, i.p.) or saline were studied in rats. Chronic fencamfamine treatment reduced body weight of rats below their normal body weight. Thereafter, weight increased, in parallel to that of control rats. There was an increasing trend in food intake in both groups and a reduction was observed in food intake on the first seven days of fencamfamine-treated rats. Fencamfamine repeated administration enhanced stereotyped sniffing while rearing behaviour gradually declined until 25 days. However, the same treatment did not interfere with the intensity of stereotypy. These findings suggest the need for a re-evaluation of current concept in the tolerance to the effects of fencamfamine and other stimulant drugs.

Animals↗
PubMed1987

Reduction of food intake by fencamfamine in rats.

Fencamfamine (1.0-10.0 mg/kg, i.p. single dose) reduced the food intake in a dose-effect relationship. The dose needed for the 50% inhibition of food intake (ID50) was 7.3 mg/kg. Fencamfamine-induced anorexia in rats (5.0 and 10.0 mg/kg) was followed by hyperactivity, stereotypy or both. Pretreatment with haloperidol antagonized the anoretic effect induced by fencamfamine. These findings suggest that the activation of central dopaminergic systems involved in feeding regulation may be responsible for the anoretic effect of fencamfamine and that this effect is associated with other central stimulant effects.

Animals↗
PubMed1985

Influence of phenoxybenzamine on the stereotyped behaviour induced by fencamfamine in rats: evidence for a qualitative alteration.

The interactions between norepinephrine (NE) and dopamine (DA) systems in mediating stereotyped behaviour induced by different doses of fencamfamine (1-30 mg/kg) were studied in male rats. Pretreatment with phenoxybenzamine (5.0 mg/kg) resulted in a significant leftward shift of the control curve for stereotypy. The qualitative analysis of the stereotyped behaviour parameters when compared to controls showed: higher rearing frequency at a dose of 3.0 mg/kg; lower locomotor activity at a dose of 6.0 mg/kg; higher licking and gnawing frequencies at a dose of 10.0 mg/kg. These findings indicate that the role of DA systems on the stereotyped behaviour induced by fencamfamine is dependent on the degree of NE transmission in the CNS.

Animals↗
PubMed1984

On the mechanism of central stimulation action of fencamfamine.

The stereotypy induced by fencamfamine (10 mg/kg i.p.) was compared in different groups of rats which had been pretreated with catecholaminergic drugs. Pretreatment with alpha-methyl-p-tyrosine (alpha-MpT) did not abolish the stereotypy, however the combination of alpha-MpT plus reserpine decreased, while reserpine alone increased this response. Pretreatment with haloperidol or metoclopramide reduced the intensity of stereotyped behaviour induced by fencamfamine, while phenoxybenzamine increased this behaviour. Fencamfamine showed low affinity for binding sites of [3H]haloperidol and [3H]dihydroergocriptine. These results support the view that fencamfamine is an indirectly acting drug of the non-amphetamine class, which releases both norepinephrine (NE) and dopamine (DA) from presynaptic terminals leading to stereotyped behaviour.

Animals↗
PubMed1983

Maternal and fetal liver enzymes of mid-to-term pregnant rats chronically treated with magnesium sulphate.

1. Pregnant rats were injected daily with 150 mg/kg body weight magnesium sulphate (MgSO4) starting at the 5th day of gestation and sacrificed at the 13th, 15th, 19th or 21st day of pregnancy. 2. Maternal liver enzymes of glycolysis (HK, PFK, PK, LDH), pentose shunt pathway (G-6-PD) and glutamate metabolism (Ala-T, Asp-T) were unaltered by the treatment. 3. Fetal liver PK, LDH, G-6-PD, Ala-T and Asp-T activities were strongly activated by MgSO4 to levels in some instances as high or even higher than those found in the adult rat liver. 4. Results support recent evidence that MgSO4 induces precocious maturation of certain morphofunctional features of the fetal rat liver. 5. Data presented herein cannot account for the strong deleterious effects of the drug on rat pregnancy. Instead, such effects would be better explained by the direct cell toxicity of MgSO4.

Animals↗
PubMed1982

Patterns of mid-to-term placental enzymes in rats treated with magnesium sulphate.

1. Pregnant rats were injected daily with 150 mg/kg b.w. of magnesium sulphate (MgSO4) starting at the 5th day gestation and sacrificed at the 13th, 15th, 19th or the 21st day of pregnancy. 2. The profiles of LDH, G-6-PD, HK and Ala-T activities in mid-to-term placentae were not changed by the drug. 3. Placental PK was strongly activated by MgSO4 in 13-19 day pregnant rats, whereas Asp-T was more severely depressed at the final phase of pregnancy. 4. Although mild to moderate changes in the flow of substrates should be predictable by the results, it seems unlikely that these could account for the reported deleterious effects of MgSO4 on rat offsprings.

Animals↗
PubMed1982

Inhibition of [3H]adenosine binding by stereoisomers of oxazepam hemisuccinate in guinea-pig brain synaptosomes.

1. The stereoisomers of oxazepam sodium hemisuccinate have been tested for their ability to inhibit the [3H]adenosine binding in guinea-pig brain synaptosomes. 2. All three stereoisomers were able to inhibit the [3H]adenosine binding in a dose-dependent fashion. 3. The IC20 values of the D-, DL- and L-stereoisomers were approximately 5 X 10(-5) M, 7.5 X 10(-5) M and 10(-4) M respectively. 4. The results are consistent with hypothesis that adenosine may be the endogenous substrata mediating some actions of the benzodiazepines.

Adenosine↗
PubMed1981

Distribution and kinetics of hippuran 131I in rats.

A six-compartment model is proposed to study hippuran kinetics in several tissues and body fluids. This comprises plasma (in which the tracer is introduced), extravascular space (anatomically not defined), kidneys (left and right), "delay" (the dead space through which the urine passes from kidneys to the bladder) and the cumulative urinary excretion. Based on accurate internal measurements of radioactivity, theoretical values which reproduced the experimental data have been fitted to a SAAM program. A good fit was observed between the curves. This study is intended to be of value for better understanding and use of tests for clinical evaluation of renal function.

Animals↗