Biomedical subjects

R Dascălu

Publications and source records attributed to R Dascălu.

23 records · Page 2Linked to original sources

PubMedDate not supplied

Calcitonin secretion in hyperthyroidism.

The level of circulatory calcitonin was determined by the RIA method in 45 hyperthyroid patients in evolution, before and after calcium stimulation or after pentagastrin injection. The basal calcitonin secretion was increased in only 7 of the 45 patients studied, exceeding 500 pg/ml. After a slow calcium loading the mean of calcitonin increased, but with variable individual values. The rapid calcium loading was not followed by significant increases after 30 minutes. After pentagastrin a secretory peak of over 1,800 pg/ml was obtained in 4/5 cases. Results point out the state of the calcitonin-secreting system in hyperthyroidism and its possible role in the skeleton protection in these patients.

Adolescent↗

PubMedDate not supplied

Patterns of urinary 17-ketosteroid fractions in hirsutism.

Fractionated 17-ketosteroids were determined in 60 females with hirsutism. The chromatographic method was adapted in the Oncological Institute of Cluj-Napoca. In 32 patients the idiopathic form of hirsutism was confirmed with normal results for all the fractions and only sometimes a slight rise of androsterone. In 18 patients an ovarian origin was affirmed; all of them had androsterone and etiocholanolone over normal limits. In ten patients, who had an adrenal origin of hirsutism the great values of DHEA (dehydroepiandrosterone) were observed. In one patient with virilizing adrenal tumour, both total 17-ketosteroids, and all fractions were much elevated DHEA being over 100 mg/24 hours.

17-Ketosteroids↗

PubMedDate not supplied

Peculiarities of diabetes in patients with hyperthyroidism.

The authors report on 5 patients aged 25 to 63, with hyperthyroidism confirmed by high and plateau radioiodine uptake curves, protein-bound iodine of more than 7.4 micrograms/dl and low values of TSH (0.95 +/- 0.7 microU/ml). The fasting blood sugar was 157.6 mg% +/- 41 on average. Glycosuria ranged from 3.8 to 20.7 g/24 h and had a mean of 11 g 8.8 g/24 h. Determination of serum immunoreactive insulin (IRI) revealed very variable values: in one patient it was nondetectable, in 3 patients it had normal values, and in one patient it exceeded 41 microU/ml. These data confirm the authors' earlier reports on the variability of the glycoregulating mechanisms in hyperthyroidism, ranging from diabetes mellitusto hyperinsulinic reaction. However, most of the patients had normal IRI and reduced tolerance to glucose. The latter is probably due to the excess of thyroid hormones.

Adult↗

PubMedDate not supplied

[Epidemiological evaluations of the incidence of posttransfusion hepatitis in Iaşi County in 1985-1995].

In the interval 1985-1995 the morbidity rate of viral hepatitis of various causes showed yearly variations, an average of 181 cases being recorded. The performed investigations revealed markers for viral hepatitis B in an yearly average of 154 cases for the 11 years under study. Posttransfusion hepatitis had an average incidence of 43 cases per year, in 59.1% the markers for viral hepatitis B being absent. 93.3% of the cases with posttransfusion hepatitis belonged to the age groups over 20 years and workers presented a mean yearly incidence of 28.3% of all cases. In 1995 the blood donors with viral hepatitis C antibodies represented 4.05% and 75% of them belonged to the age groups 21-60 years, 50% of them being industrial workers and 40% having the A II blood group. Of the 321 admitted cases, 26.7% presented AgHBs, 8.4% AcVHC, in 2.3% markers for both viruses were evidenced and in 62.8% of the cases the diagnosis was made on epidemiological criteria and serologic exclusion (non A, B, C) without excluding the possible intervention of other hepatitic viruses.

Adolescent↗

PubMedDate not supplied

Skeletal calcium retention in hyperthyroidism and in vitro calcitonin inactivation.

Studies on patients with severe hyperthyroidism revealed an increased skeletal avidity for calcium, expressed in terms of net retention, after a three-hour i.v. load of 10mg Ca/kg body weight. For the same hyperthyroid subjects the calcitonin inactivating potency of the sera was tested in vitro. The results were expressed as restant hypocalcemic potency of the calcitonin after incubation with the serum fractions. In hyperthyroid subjects two fractions in dilutions of 1:10 reduced the hypocalcemic activity of calcitonin by 75%. In normals this activity appeared only in one fraction. All these results suggest a prompt calcitonin release during calcium infusion which is however less efficient, probably because of the increased amount of calcitonin inactivating factor present in sera. The serum inactivating factor generally contributes to the short-time activity of calcitonin both in normals and in some clinical states with bone calcium imbalance.

Bone and Bones↗