Selecting the appropriate imaging modality.
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Arthrography↗
Biomedical subjects
R Daffner
Publications and source records attributed to R Daffner.
Splenic abscess.
Fourteen cases of splenic abscess are reported and 159 cases previously cited in the literature are reviewed. The incidence, predisposing factors, pathogenesis, clinical features, bacteriology and radiologic findings are discussed. Infective endocarditis was the most common single antecedent infection. Hemoglobinopathies, non-penetrating abdominal trauma, and gastrointestinal malignancy appear to predispose the spleen to abscess formation. Emphasis is placed on clinical features and radiologic findings to aid practitioners in diagnosing this uncommon but often fatal infection. Also emphasized is the necessity for prompt surgical intervention when splenic abscess is suspected. An approach to the antimicrobial therapy in different clinical settings is outlined.
Abscess↗
Synchronous and metachronous squamous cell carcinomas of the head, neck and esophagus.
Thirty-four (1%) of 3,287 patients with squamous carcinoma of the head-neck developed carcinoma of the esophagus. The clinical and radiological importance of this relationship is emphasized. Since there is an increased incidence of esophageal carcinoma in this group, perhaps all such patients should have an annual esophagogram.
Adult↗
The stimulatory and inhibitory function of theophylline on amino acid-induced insulin release: studies with the perfused rat pancreas.
The effects of 5 mM theophylline on L-phenylalanine, L-alanine, and L-leucine-induced insulin secretion were studied using the isolated perfused rat pancreas, varying the sequence of the stimuli. Theophylline in the absence or presence of 3 mM D-glucose caused a small amount of insulin release with a slow onset and a slight and steady increase. Theophylline had no effect on phenylalanine (5, 10, or 20 mM)-induced insulin release independent of the sequence of stimuli. Alanine (20 mM), in the absence of glucose, had no significant insulin stimulatory action. When theophylline was added during the alanine perfusion only a small insulin release, comparable to that given by theophylline alone, could be observed. However, superimposing alanine on a theophylline perfusion led to a potentiation of insulin release. The leucine-induced insulin secretion was significantly altered by the addition of theophylline. At a low concentration of leucine (5 mM) theophylline caused potentiation of leucine-induced insulin secretion. At 10 and 20 mM leucine, theophylline led to a rapid concentration-dependent inhibitory period, followed by a potentiation in the case of 10 mM leucine, and by a restoration of the secretion rate at 20 mM leucine which did not exceed the secretion rate of 20 mM leucine alone. Subsequent removal of theophylline caused a marked "off effect." When 5 or 20 mM leucine was superimposed on a theophylline perfusion, a marked dose-dependent potentiation of the biphasic leucine-induced insulin release and no inhibitory phase could be observed. From these data it must be concluded that the effect of theophylline on the insulin secretory reposure of the beta cell to theophylline and the stimulus. Possible explanations for these phenomena are discussed.
Alanine↗