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Biomedical subjects

R D deShazo

Publications and source records attributed to R D deShazo.

88 records · Page 5Linked to original sources
PubMed1982

Lidocaine effects on immunocompetent cells. Implications for studies of cells obtained by bronchoalveolar lavage.

Immunologic data obtained from bronchoalveolar lavage (BAL) is useful for both clinical and investigative purposes. Although lidocaine, used for local anesthesia, is present in BAL in up to 12 mmol concentration, its effects on immunologic tests are unclear. The results of our study show that lidocaine has profound effects on the results of functional studies of immuno-competent cells. Care should be taken to quantify, standardize, and limit the exposure of alveolar cells to lidocaine during bronchoscopy if such studies are to be performed. However, exposure of cells for 25 minutes or less to lidocaine solutions up to 12mmol in concentration does not affect a variety of immunologic tests of interest. At the same time, carefully controlled use of lidocaine in lavage solutions significantly increases the number of cells obtained for study.

B-Lymphocytes↗
PubMed1979

Selective immunoglobulin A deficiency associated with modular lymphoid hyperplasia.

Nodular lymphoid hyperplasia (NLH) has been firmly associated with syndromes of hypogammaglobulinemia but not with selective absence of IgA. We report the case of a 5-yr-old girl with the triad of selective IgA deficiency, NLH of the small bowel, and giardiasis. Results of an extensive immunologic investigation, including immunohistochemical examinations of small bowel biopsies, support the hypothesis that the basic defect responsible for IgA deficiency in this patient was the failure of precursor IgM-bearing lymphocytes to differentiate into IgA-producing plasma cells. Furthermore, the abundance of IgM-bearing cells in biopsy specimens demonstrates the existence of a compensatory mechanism in the intestine to substitute IgM for the absent IgA.

Child, Preschool↗
PubMed1978

Insulin allergy and insulin resistance: two immunologic reactions.

Insulin allergy and insulin resistance can cause life-threatening problems for diabetic patients. Fortunately, allergic manifestations are usually localized, but increasingly severe local reactions can precede a systemic reaction. How use of newer and purer insulin preparations than those previously available will affect the incidence of immunologic reactions is yet to be determined.

Animals↗
PubMed1977

Severe persistent biphasic local (immediate and late) skin reactions to insulin.

A patient with adult-onset insulin-requirging diabetes mellitus had persistent severe local reactions to all available insulins of animal origin. Skin reactions were biphasic in nature with both immediate and late characteristics. An extensive immunologic investigation of this problem was undertaken, revealing evidence of reaginic antibody involvement in the reactions. Routine histologic studies suggested the possibility that Arthus-type mechanisms played a part, although this impression was not confirmed by immunofluorescent microscopy. A program of medical management provided some relief of symptoms.

Aspergillus fumigatus↗
PubMed1975

The spectrum of systemic vasculitis: a classification to aid diagnosis.

Determining the cause of systemic vasculitis can be facilitated by a clinicopathologic classification of the syndrome. The considerations in differential diagnosis include periarteritis nodosa, leukocytoclastic angiitis (hypersensitivity angiitis, Schonlein-Henoch purpura, other disease-associated vasculitis), Wegener's granulomatosis, allergic granulomatosis (granulomatous angiitis), and giant cell arteritis.

Arteritis↗
PubMedDate not supplied

Seroconversion to human immunodeficiency virus (HIV) in hemophiliacs. Relation to lymphadenopathy.

The authors studied the natural history of human immunodeficiency virus (HIV) exposure in 187 hemophiliacs followed for an average of 45 months. Overall, 55 percent developed antibody specific for HIV and 21 percent developed persistent generalized lymphadenopathy. Most patients seroconverted sometime between early 1982 and the end of 1984. Four patients developed acquired immune deficiency syndrome (AIDS) and four seropositive patients developed idiopathic thrombocytopenia (ITP). One of the four patients who developed AIDS and three of the four with ITP had preexisting lymphadenopathy. None of the 10 patients with lymphadenopathy or the 20 asymptomatic patients was seropositive for human T-lymphotropic virus, type I. Although seropositivity and lymphadenopathy have been found in many of the authors' patients, few have developed clinical disease that can be related to HIV infection.

AIDS-Related Complex↗
PubMedDate not supplied

Evaluation of patients with local reactions to insulin with skin tests and in vitro techniques.

To better understand the part played by IgE and IgG antibody in the production of dermal reactions to insulin and the usefulness of skin tests in the evaluation of these reactions, we studied 21 diabetic patients referred for evaluation of large local insulin reactions, 46 diabetic patients without local insulin reactions, and 22 healthy nondiabetic controls. Study subjects were skin tested with 15 different insulins, and the results were evaluated over 48 h. All control subjects and 41 of 46 diabetic patients without local reactions were skin-test negative to insulin. The 11% of diabetic patients who reacted had positive wheal-and-flare reactions at 20 min to animal-species insulin but negative skin tests to human insulin. Study revealed two subgroups of patients with histories of local reactions. Ten (48%) of these patients had negative skin tests to insulin. Five of this subgroup remained skin-test negative to quantities of less than or equal to 8 U insulin/skin test. Eleven (52%) of the patients formed a subgroup with positive insulin skin tests; most of these patients were skin-test positive to human insulin and to beef, pork, or both insulins as well. Although the group mean insulin-specific IgE values of this latter subgroup were significantly higher than those of any other study group, overlap of these individual IgE values did not allow separation of specific individuals with positive skin tests from those of patients on insulin without dermal reactions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Reactions to imported fire ant stings.

Reactions to the sting of the imported fire ant are an increasing problem for residents of the Gulf South. Three recent evolutionary changes suggest that the habitat of the ants will continue to expand. This article gives a brief review of the problem, including unresolved questions related to management of sting reactions.

Allergens↗
PubMedDate not supplied

Pulmonary reactions induced by drugs: a clinical compendium.

With the increasing number of drugs, the list of agents which are capable of inducing pulmonary reactions continues to lengthen. This article is a compendium of presently available information on drug induced pulmonary reactions which we have found clinically useful. We have divided the drugs in groups on the basis of two features, pharmacologic actions and type of pulmonary reactions. A total of 109 drugs are cited. Categories of pharmacologic actions include cytotoxic drugs, analgesic and antirheumatic drugs, antimicrobial agents, vasoactive drugs, tranquilizers, anticonvulsants, antidepressants, antiarrhythmics, oral antidiabetics and a group of miscellaneous drugs. Type of pulmonary reactions include pulmonary eosinophilia, bronchoconstriction, acute interstitial pulmonary disease, mediastinic involvement, pleural effusion, pulmonary hypertension, pulmonary calcifications, pulmonary infections and drugs reported to cause drug-induced Systemic Lupus Erythematosus.

Adrenergic beta-Antagonists↗