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Biomedical subjects

R D Wilson

Publications and source records attributed to R D Wilson.

At least 91 records · Page 5Linked to original sources
PubMed1987

Morquio disease presenting as hydrops fetalis and enzyme analysis of chorionic villus tissue in a subsequent pregnancy.

We describe the prenatal diagnosis of a fetus at risk for mucopolysaccharidosis (MPS) Type IVA (Morquio syndrome) using enzyme analysis of chorionic villus tissue. The family had two previous affected children, one with progressive nonimmune hydrops fetalis presenting at 16 weeks gestation and one mildly affected 5 year old. The parents had decreased levels of N-acetyl galactosamine-6-sulphate sulphatase in cultured skin fibroblasts indicating that carrier detection is possible for Morquio A syndrome.

Adult↗
PubMed1987

Analysis of chromosomally normal spontaneous abortions after chorionic villus sampling.

Analysis of patients who spontaneously aborted chromosomally normal pregnancies following chorionic villus sampling (CVS) revealed an overall loss rate of 5.4% but a rate of only 3.2% if the procedure was performed between 9 and 12 menstrual weeks. There is preliminary evidence to suggest that a small but significant risk of infection is related to CVS.

Abortion, Spontaneous↗
PubMed1986

In vitro antibacterial activity of enoxacin (CI-919).

Antibacterial activity of enoxacin was evaluated against more than 3,700 clinical isolates using the agar-dilution method and an inoculum of 10(4)-10(5) cells per site. For comparison other antibiotics appropriate for each species were also included. For most enterobacteria and for Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa, the MIC90 of enoxacin was below 2 mg/l. Serratia marcescens was more resistant; the MIC90 being 4 mg/ml. Enoxacin also showed high activity against Campylobacter jejuni and Neisseria gonorrhoeae. Streptococci were comparatively resistant, 32 mg/l to 64 mg/l of the compound being required to inhibit 90% of strains.

Anti-Bacterial Agents↗
PubMed1986

Spontaneous abortion and pregnancy outcome after normal first-trimester ultrasound examination.

The aim of the study was to assess the spontaneous abortion rate and pregnancy outcome in a population of women with a normal first-trimester ultrasound examination. Gestational age or bleeding was the indication for 90% of the ultrasound scans. The spontaneous abortion rate increased with advancing maternal age. Other factors affecting the rate were indication for the scan and gestational age at the time of the scan. In the overall group, disregarding maternal age, the spontaneous abortion rate was 2.3%. This background rate of spontaneous abortion can be used to assess the added risk of chorionic villus sampling or other first- or second-trimester procedures. The incidence of antepartum and intrapartum complications in these pregnancies corresponded well with published figures.

Abortion, Spontaneous↗
PubMed1986

Somatosensory-evoked potential induced by stimulation of the caudal tibial nerve in awake and barbiturate-anesthetized sheep.

The somatosensory-evoked potential (SEP) from caudal tibial nerve stimulation was recorded in sheep, using surgically implanted electrodes. Peak latencies of the SEP remained stable throughout the 3- to 5-month recording period. Wave-form and peak latencies from awake sheep and concomitant changes during barbiturate anesthesia were compared with those reported for other animal species, including man. Wave form components representing activities from the primary somesthetic cortex, association cortex, and non-specific diffuse projections were differentially susceptible to barbiturate anesthesia. The neural source of the initial positive peak (mean latency = 19 ms) was resistant to anesthesia and represented primary somesthetic activity of the cortex. Sheep with surgically implanted electrodes yielded stable latencies with SEP wave-form features essentially homologous to those reported for other animal species.

Anesthesia↗
PubMed1985

Tuberous sclerosis: case report and investigation of family members.

Familial tuberous sclerosis probably occurs more often than is indicated by the literature: many family members show signs of being carriers of the gene for the disease when carefully examined. This article reports on a family with documented tuberous sclerosis in three generations and discusses the examination and investigation of at-risk family members, including the newborn, for signs of the disease. The potential teratogenic effects of anticonvulsants, used to control seizures in tuberous sclerosis, are also discussed.

Adult↗
PubMed1985

Oculocerebrocutaneous syndrome.

A female infant was found at birth to have an oculocerebrocutaneous syndrome in which the main clinical features include orbital cyst, cerebral malformations, accessory skin tags, and focal hypoplasia or "punched-out" skin lesions. This case, like the four previously reported, was sporadic.

Brain↗
PubMed1985

Bilateral renal agenesis in twins.

We present the second report of like-sex twins concordantly affected with bilateral renal agenesis (BRA). Mode of inheritance is proposed to be autosomal dominant. Screening of first-degree relatives of the BRA proband by ultrasound of the GU system is recommended. Prenatal diagnosis with second-trimester ultrasound screening is recommended when a previous fetus has been affected by bilateral renal agenesis.

Adult↗
PubMed1985

Renal agenesis in British Columbia.

We review the incidence of bilateral and unilateral renal agenesis occurring in more than 625,000 consecutive births in British Columbia from 1952 to 1982. In total, 92 cases of bilateral renal agenesis and 117 cases of unilateral renal agenesis were identified. Congenital anomalies occurring in association with these conditions were also analyzed. The findings of the study support a mechanism in at least a proportion of cases of a primary developmental defect involving multiple systems within the fetus, with oligohydramnios being the result of the syndrome not the cause. Oligohydramnios no doubt contributes to the anomalies of the face, musculoskeletal system, and genitalia. No trends in changing incidence over time were identified.

Abnormalities, Multiple↗
PubMed1984

Benzo[a]pyrene uptake by lymph: a possible transport mode for immunosuppressive chemicals.

Benzo[a]pyrene, a lipophilic promutagen, reached maximal concentrations in the thoracic duct lymphatic circulation within 2 h after gastric instillation. Benzo[a]pyrene in lymph obtained by thoracic duct cannulation decreased to approximately control levels within 4 h after treatment. When lymph was not allowed to enter the blood vascular circulation, serum levels of benzo[a]pyrene increased very slowly, suggesting minimal mesenteric blood vascular absorption of the lipophilic hydrocarbon. Benzo[a]pyrene partitions into lymph lipoproteins as a function of the lipoprotein concentration. Data suggest that low-density lipoproteins may take up benzo[a]pyrene more efficiently than do very low-density or high-density lipoproteins, and that lymph components other than lipoproteins do not take up and transport benzo[a]pyrene. We propose that lipophilic xenobiotic compounds interact with cells of the immune system via lymphatic lipoprotein transport of potentially mutagenic, carcinogenic, or immunosuppressive agents.

Absorption↗
PubMed1984

A fatal case of Legionnaires' disease in an immunocompromised patient.

A 65-year-old woman presented with an autoimmune hemolytic anemia and was subsequently diagnosed as having malignant lymphoma. Cytotoxic chemotherapy was followed by the development of fatal Legionnaires' disease, confirmed by isolation of L. pneumophila serogroup 6 from pleural and lung aspirate specimens. This is believed to be the first reported isolation of serogroup 6 L. pneumophila in Australia.

Aged↗