Search PubMed⌕ Search

Biomedical subjects

R D Thompson

Publications and source records attributed to R D Thompson.

At least 91 records · Page 5Linked to original sources
PubMed1976

Failure of soybean trypsin inhibitor to exert deleterious effects in calves.

To evaluate nutritional effects induced in calves by feeding soybean trypsin inhibitor, 16 calves were fed 1) raw soybeans, 2) heated soybeans, 3) heated soybeans plus soybean trypsin inhibitor, 4) heated (raw soybeans plus soybean trypsin inhibitor). Ration 1 caused depression of growth and reduced digestibility of protein and fat as compared to Ration 2. No differences were significant in calves fed Rations 3 and 4. The weights and enzymatic activities of pancreas were similar in all groups. Soybean trypsin inhibitor plays a minor role, if any, in calf nutrition.

Animal Feed↗
PubMed1975

Determination of mercury-containing pharmaceuticals by vapor phase atomic absorption spectroscopy.

A procedure was developed for the determination of mercurials of pharmaceutical interest. Protic acid cleavage of the compound was followed by reduction of the resulting mercuric ion and vapor phase atomic absorption spectroscopy. This procedure was applied to 11 different mercurial compounds in various pharmaceutical preparations and offers excellent sensitivity with respect to presently used compendial assays. Comparative analytical data between this procedure and compendial methodology are presented.

Chemistry, Pharmaceutical↗
PubMed1975

Phenylpropanolamine inhibits feeding, but not drinking, induced by hypothalamic stimulation.

In rats bearing lateral hypothalamic electrodes that elicited both feeding and drinking, intraperitoneal injection of the appetite suppressant drug phenylpropanolamine (Propadrine) inhibited only feeding. This occurred whether feeding and drinking were tested simultaneously or separately. Selective inhibition of lateral hypothalamic feeding also followed injection of this drug through lateral, but not medial, hypothalamic electrode cannulas. We conclude that hypothalamically induced feeding is under some of the same pharmacological controls as spontaneous feeding, that this control may be exerted, in part, in or near the lateral hypothalamus, and that the neural systems which induce feeding and drinking during hypothalamic stimulation can be pharmacologically separated.

Animals↗
PubMed1975

Determination of methadone hydrochloride in a maintenance dosage formulation.

A colorimetric method for direct quantitative assay of methadone hydrochloride in liquid oral dosage forms is presented. The procedure involves the formation of a dye complex with bromothymol blue buffer solution. The resultant complex is extracted with benzene and measured spectrophotometrically. Duplicate tests on the formulation showed 99.2% of the labeled amount of methadone.

Administration, Oral↗
PubMed1972

Vampire bat control by systemic treatment of livestock with an anticoagulant.

The blood of beef cattle given single doses (1 milligram per kilogram of body weight) of diphenadione (2-diphenylacetyl-1,3-indandione) became toxic to vampire bats (Desmodus rotundus) and remained toxic for 3 days without harming the cattle. Cattle at three ranches in Mexico treated with single intraruminal injections of diphenadione experienced a reduction in vampire bat bites of 93 percent. Bioassays of milk and liver from cattle treated orally with diphenadione in the laboratory indicated that there were no residue problems.

Administration, Oral↗
PubMed1971

Automated preference testing apparatus for rating palatability of foods.

An electronic preference testing apparatus is described for measuring taste preference of rodents and other small animals with solid or liquid foods. The apparatus is designed on the principle of the two-choice, preference technique. It operates photoelectrically with a sequence of presentations so that whenever a subject eats from a compartmentalized food tray, a standard and a test food are each briefly sampled alone before both foods are presented together (in alternate positions) for preference determination. Preferences are automatically recorded on digital counters. The apparatus is built in two modules (a preference tester and the master control) connected by multiconductor cable. The modular design provides portability and isolation of the animals from the major noise-producing components. Diagrams of the apparatus are given, and test results from a trial that evaluated positional bias and a sucrose-concentration preference experiment are presented to demonstrate its application in research.

Animals↗