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Biomedical subjects

R D Olson

Publications and source records attributed to R D Olson.

136 records · Page 8Linked to original sources
PubMedDate not supplied

Endogenous opiates: 1988.

This paper is the eleventh installment in our annual review of the research during the past year involving the endogenous opiate system. It is concerned with nonanalgesic and behavioral studies of the opiate peptides that were published during 1988. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal, renal, and hepatic functions; mental illness; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical activity; locomotor activity; sex, pregnancy, and development; immunology and cancer; and other behavior.

Animals↗
PubMedDate not supplied

Endogenous opiates: 1987.

This paper is the tenth installment of our annual review of the research during the past year involving the endogenous opiate system. It covers the nonanalgesia and behavioral studies of the opiate peptides published in 1987. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal and renal activity; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical activity; locomotor activity; sex, pregnancy, and development; immunology and cancer; and other behavior.

Animals↗
PubMedDate not supplied

Endogenous opiates: 1989.

This paper is the twelfth installment of our annual review of the research published during 1989 involving the behavioral, nonanalgesic, effects of the endogenous opiate peptides. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal and renal functions; mental illness; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; locomotor activity; sex, development, pregnancy, and aging; immunological responses; and other behavior.

Aging↗
PubMedDate not supplied

Endogenous opiates: 1990.

This paper, an examination of works published during 1990, is thirteenth in a series of our annual reviews of the research involving the behavioral, nonanalgesic, effects of the endogenous opiate peptides. The specific topics this year include stress; tolerance and dependence, eating; drinking; gastrointestinal, renal, and hepatic functions; mental illness; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; locomotor activity; sex, pregnancy, development, and aging; immunological responses; and other behavior.

Animals↗
PubMedDate not supplied

Endogenous opiates: 1991.

This paper is the fourteenth installment of our annual review of research concerning the opiate system. It includes papers published during 1991 involving the behavioral, nonanalgesic, effects of the endogenous opiate peptides. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal and renal function; mental illness and mood; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; general activity and locomotion; sex, pregnancy, and development; immunological responses; and other behaviors.

Animals↗
PubMedDate not supplied

Endogenous opiates: 1992.

This paper is the fifteenth installment of our annual review of research concerning the opiate system. It includes papers published during 1992 involving the behavioral, non-analgesic, effects of the endogenous opiate peptides. The specific topics this year include stress; tolerance and dependence; eating; drinking; gastrointestinal and renal function; mental illness and mood; learning, memory, and reward; cardiovascular responses; respiration and thermoregulation; seizures and other neurological disorders; electrical-related activity; general activity and locomotion; sex, pregnancy, and development; immunological responses; and other behaviors.

Amino Acid Sequence↗
PubMedDate not supplied

Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria.

Toxic shock syndrome is associated with reversible cardiomyopathy. The cardiac dysfunction may be mediated by toxic shock syndrome toxin 1 (TSST-1), an exotoxin generated by Staphylococcus aureus. However, the effects of purified TSST-1 on cardiac function are unknown. In a study of the toxin's effect on myocardial function, TSST-1 (200 ng/mL) was added to muscle baths containing isolated rabbit atria. TSST-1 caused time-dependent inhibition of developed force (systolic function) but did not alter resting force (an index of muscle stiffness or cardiac compliance). These data show that TSST-1 can directly inhibit myocardial function, but the significance of this effect in patients with toxic shock syndrome remains to be determined.

Animals↗
PubMedDate not supplied

Treatment of postischemic reperfusion cardiac injury with a perfluorochemical solution.

We assessed the effects of a perfluorochemical solution on reperfusion injury in a globally ischemic heart model. An isolated rabbit heart, retrogradely perfused at a constant flow rate, served as our experimental model. After initial perfusion with whole blood, hearts were exposed to 30 min of normothermic global ischemia. Reperfusion was then begun with either whole blood or a 20% perfluorochemical solution (FC-43). After 120 min of reperfusion, a markedly greater recovery of contractile function was observed in the perfluorochemical-reperfused hearts (85 +/- 5% of baseline developed pressure) compared with blood-reperfused hearts (57 +/- 3% of baseline developed pressure). This recovery of function was accomplished with only 1 h of perfluorochemical reperfusion and was not lost on returning to blood perfusion. The improved recovery of function could not be attributed to the chemical composition, oxygen-carrying capacity, pH, or temperature of the perfluorochemical perfusate. Neither could the beneficial effects of perfluorochemical be related to differences in left ventricular resting pressure. We speculate that, because of marked differences in coronary resistance during reperfusion with perfluorochemical solution and blood, improved recovery of cardiac function is related to the superior rheological properties of perfluorochemicals.

Animals↗