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Biomedical subjects

R D MacArthur

Publications and source records attributed to R D MacArthur.

23 records · Page 2Linked to original sources

An evaluation of the use of statistical methodology in the Journal of Infectious Diseases.

One hundred fourteen articles published in the Journal of Infectious Diseases in 1982 were evaluated for the occurrence of eight commonly made statistical errors. Seventy-one percent of Original Articles and 50% of presentations in the Data Forum used statistical methods to analyze results. Almost all of the articles that used statistics contained at least one statistical error. The most common inadequacy, which occurred in 95% of the articles with statistical data, was the statement of a probability value without a complete summary of the statistical results. The most common error was the failure to include a correction for multiple comparisons. These results suggest that a more clearly stated statistical policy, a more explicit set of instructions to authors, and closer editorial attention to statistical methodology, perhaps at the prepublication phase, would improve the validity of articles published in the Journal.

Communicable Diseases↗

Efficacy and safety of abacavir plus lamivudine versus didanosine plus stavudine when combined with a protease inhibitor, a nonnucleoside reverse transcriptase inhibitor, or both in HIV-1 positive antiretroviral-naive persons.

PURPOSE: The combination of abacavir + lamivudine (ABC+3TC) versus didanosine + stavudine (ddI+d4T), each combined with other classes of antiretrovirals (ARVs) in ARV-naive patients, was compared for the combined endpoint of time to plasma HIV RNA >50 copies/mL (at or after the 8-month visit) or death (primary endpoint) in a nested substudy of an ongoing multicenter randomized trial. METHOD: The substudy enrolled 182 patients; mean HIV RNA and CD4+ cell counts at baseline were 5.1 log10 copies/mL and 212 cells/mm3, respectively. RESULTS: After a median follow-up of 28 months, rates of primary endpoint were 57.2 and 67.8 per 100 person-years for the ABC+3TC and ddI+d4T groups (hazard ratio [HR]=0.81, 95% confidence interval [CI] 0.58-1.14, p=.23). CONCLUSION: There was a trend for treatments containing ABC+3TC to be better than treatments containing ddI+d4T with respect to HIV RNA decreases, CD4+ cell count increases, and tolerability.

Anti-HIV Agents↗