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Biomedical subjects

R D Hunt

Publications and source records attributed to R D Hunt.

At least 73 records · Page 4Linked to original sources
PubMed1977

Long-term effect of low dietary calcium:phosphate ratio on the skeleton of Cebus albifrons monkeys.

Wildcaught cinnamon ringtail monkeys, Cebus albifrons, were fed diets with Ca:P ratios of 1:4 1:2.1 1:0,4, and 1:0.5 for 3 to 88 months. Monkeys fed the diet with Ca:P ratios of 1:4 and 1:21 C ratios similar to that of human diets) had minor microscopic changes suggestive of osteoporosis when compared to other species of animals. The changes were not detected by conventional or magnification radiography or by 125I photon absorptiometry. These findings are in in striking contrast to studies in other animals where similar diets resulted in significant bone resorption within 6 weeks to 6 months. This study suggests that the non-human primate may be a more appropriate animal model for the investigation of nutritional osteopenia in man in whom bone resorption appears to be a slowly progressive process. In view of our findings, studies using lower animal species must be re-evaluated with respect to the hypothesis that high dietary phosphate is a significant etiologic factor in senile osteoporosis in man.

Alkaline Phosphatase↗
PubMed1976

Bromocriptine in Huntington chorea.

Following a recent report that apomorphine hydrochloride alleviates the involuntary movements of Huntington chorea, we have investigated another dopamine receptor agonist, bromocriptine, in this disease. A double-blind crossover study in six patients showed that rather than improving chorea, bromocriptine induced an exacerbation. This finding supports the view that choreatic movements correlate with overactivity in dopaminergic systems.

Adult↗
PubMed1976

Glomerulonephritis in the owl monkey (Aotus trivirgatus): ultrastructural observations.

The kidneys of 11 clinically healthy owl monkeys (Aotus trivirgatus) acquired from four different sources were examined by light and electron microscopy. Eight of the 11 animals had morphologic evidence of glomerulonephritis. The lesions were characterized by one or more of the following changes: focal or segmental thickening of the glomerular basement membrane; proliferation of mesangial cells with increased production of mesangial matrix; and fibrosis and hyalinization of glomeruli with and without inflammatory cellular infiltration. Five of the eight animals with one or more of the above described changes had electron-dense deposits compatible with immune complex deposits in the intra-membranous and subepithelial regions of the basement membrane. The nature and source of the antigen or antigens responsible for the lesions are unknown.

Animals↗
PubMed1976

The owl monkey (Aotus trivirgatus) as an animal model for viral diseases and oncologic studies.

The owl monkey (Aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. Studies at this institution have been primarily concerned with Herpesvirus saimiri, the Epstein-Barr virus, H tamarinus, and H simplex. These studies have shown that H saimiri is oncogenic when inoculated into primates, that the malignancy induced by H saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of H saimiri can be modified by passing the virus in a nonpermissive cellular host, that the owl monkey is a useful model for studying the oncogenicity of the Epstein-Barr virus, and the fatal disease induced in owl monkeys by H tamarinus and H simplex can be prevented by vaccination with nonpathogenic variants of these viruses.

Animals↗
PubMed1976

Pseudotuberculosis (Yersinia enterocolitica) in the owl monkey (Aotus trivirgatus).

Pseudotuberculosis caused by Yersinia enterocolitica was observed as an enzootic disease of the owl monkey (Aotus trivirgatus). A description is given of the natural disease and its successful reproduction in owl monkeys. The disease was characterized by purulent and necrotizing enteritis, hepatitis, and splenitis. Large colonies of the causative organism were consistently associated with the lesions. Although pseudotuberculosis has been reported in other monkeys, the disease in the authors' primate colonies has been restricted to the owl monkey.

Animals↗
PubMed1976

Glomerulonephritis in the owl monkey (Aotus trivirgatus).

Glomerular disease was observed in 45 of 57 owl monkeys (Aotus trivirgatus). The disease was minimal in eight of the affected animals and moderate to extensive with respect to severity of the lesions and the number of glomeruli involved in the remainder. The lesions were characterized by proliferation and hypertrophy of mesangial and epithelial cells, increase in mesangial matrix, thickening of basement membranes, and sclerosis. Immunofluorescent staining suggested that the disease was an immune complex glomerulonephritis.

Animals↗
PubMed1975

Experimental horizontal transmission of Herpesvirus saimiri from squirrel monkeys to an owl monkey.

Herpesvirus saimiri was naturally transmitted from squirrel monkeys excreting the virus to one of two owl monkeys housed in the same cage. The owl monkey became infected approximately three months after contact was initiated. H. saimiri was consistently isolated from the peripheral lymphocytes until this animal died eight months later. During this period the owl monkey developed specific antibody to H. saimiri to a maximal neutralization index of 5.5 logs. The other monkey remained uninfected for an ovservation period of one year. The documentation of this horizontal transmission of H. saimiri infection from squirrel monkeys to an owl monkey suggests that owl monkeys developing spontaneous malignant lymphomas associated with H. saimiri infection may also have acquired the infection in this manner.

Animals↗
PubMed1975

Clinicopathologic characterization of Herpesvirus saimiri malignant lymphoma in New Zealand white rabbits.

Twenty-two of 39 rabbits inoculated with Herpesvirus saimiri developed malignant lymphoma and either died or were killed between 17 and 165 days after inoculation. No clinical signs were present in animals developing the disease before 46 days, but all other rabbits had a severe conjunctivitis, nasal discharge, and dyspnea resulting from a lymphocytic invasion of the ocular and nasal tissues. Four rabbits developed terminal leukemia. Pathologically, the disease resembled H. saimiri malignant lymphoma in nonhuman primates; there was extensive diffuse infiltration of most organs and tissues with either a lymphocytic or lymphoblastic infiltrate. Tumor nodules or masses seen in some forms of malignant lymphoma were not present. In contrast to nonhuman primates, all affected rabbits showed invasion of the skin of the nose and eyelids, conjunctiva, iris, ciliary body, and choroid. In 3 rabbits there was slight infiltration into the brain, not noted in nonhuman primates. The susceptibility of rabbits extended the host range of H. saimiri beyond the order Primates.

Animals↗
PubMed1975

Spontaneous Herpesvirus saimiri lymphoma in owl monkeys.

Three examples of spontaneous malignant lymphoma were observed in owl monkeys 23, 81, and 183 days after arrival in our laboratories. The pathological features of the disease were analogous to experimentally induced Herpesvirus saimiri lymphoma. H. saimiri was recovered from 2 animals (it was not attempted from one case) and one isolate was shown to reproduce characteristic H. saimiri malignant lymphoma. Each monkey originated in Peru in contrast to our usual source of owl monkeys which originate in Barranquilla, Colombia. Samples collected from owl monkeys in Peru did not reveal antibodies to H. saimiri nor were virus isolated from cocultured leukocytes. Squirrel monkeys in the same geographical location all carried H. saimiri. The observations indicate that H. saimiri lymphoma can occur as a spontaneous disease and that the virus can cross the same taxonomic lines in nature as in the laboratory.

Animals↗
PubMed1975

Multiple Herpesvirus simiae isolation from a rhesus monkey which died of cerebral infarction.

A rhesus monkey housed in the New England Regional Primate Research Center for more than 4 yr died after an illness of 19 da. Clinical signs included central nervous system involvement and ulcers on the labial mucosa. Microscopically, the cause of death was established as multiple cerebral infarction. Lesions characteristic of herpesvirus infections were not present in the brain nor in any other tissue; however, Herpesvirus simiae was isolated from oral and anal swabs as well as from tongue and lung tissue. Inoculation of this agent in H simiae antibody negative rhesus monkeys resulted in infection, as indicated by virus isolation, serologic conversion, conjunctivitis, and development of ulcers at the mucoepithelial border, but fatal infection did not develop.

Anal Canal↗