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Biomedical subjects

R D Harris

Publications and source records attributed to R D Harris.

At least 127 records · Page 7Linked to original sources
PubMed1979

Prolactin suppression of leukocyte chemotaxis in vitro.

Leukocyte chemotaxis in vitro was studied for cells from patients with pituitary adenomas. Leukocytes obtained preoperatively from two of three patients with elevated serum prolactin levels demonstrated chemotaxic alterations described in other malignant disease. Statistically significant suppression of chemotaxis occurred in the leukocytes of four of 12 specimens from normal donors at concentrations of 1000 ng/ml, and in four of eight specimens at 2000 ng/ml of prolactin in preincubation media. Thus prolactin concentration may influence the motility of leukocytes. The variable neoplastic behavior of morphologically similar pituitary adenomas may, in part, reflect a neurohormonally altered host response to the presence of these lesions.

Adenoma↗
PubMed1979

Transnasal excision of a neurohypophyseal tumor.

Neurohypophyseal tumors are rare. A case of a glioma of the neurohypophysis is presented. The tumor closely resembled pituicytomas or infundibulomas. Management of these lesions poses special problems as their natural history is unclear. This tumor was excised via the transnasal, transphenoidal route and there has been no recurrence during the subsequent thirty months. The transnasal approach for posterior lobe tumors appears to be acceptable for those confined to the sella turcica or displaying minimal suprasellar extension. The literature is reviewed.

Adult↗
PubMed1978

Value of computerized tomography in evaluation of kidney.

The use of intravenous iodinated contrast material after a preliminary computerized axial tomographic scan of the kidney has been an extremely valuable adjunct in differentiating benign, malignant, and some inflammatory processes. The diagnosis of type of lesion present has been facilitated and allows direction for further diagnosis and therapy.

Carbuncle↗
PubMed1978

Surface topography of normal and neoplastic human anterior pituitary cells maintained in vitro.

Pituitary tissues were obtained from 25 patients who underwent surgery for excision of pituitary macroadenomas, selective excision of microadenomas, or removal of a normal gland for palliation of metastatic cancer. Cells thus obtained were maintained in vitro for varying intervals, fixed, and examined by light (phase contrast), microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Previous SEM reports indicate that surface topography of in vitro neoplastic cells displays features that may correlate with neoplastic behavior. Cultured normal and pituitary tumor cells did not display these surface differences, with one exception, a prolactin-secreting microadenoma. Characteristic patterns for the cell populations were identified. Certain cell types appeared in all the cultures: 1) large and small granule-containing cells; 2) flat and irregular cells; 31 spindle-shaped cells; and 4) spherical, irregularly surfaced cells. In one case of an endocrine-inactive juvenile pituitary chromophobe adenoma, unique cells were observed. Surface topography did not appear to be of predictive value in determining the neoplastic character of pituitary tumors.

Adenoma, Basophil↗
PubMed1976

Synthetic, cross-linked polypentapeptide fo tropoelastin: an anisotropic, fibrillar elastomer.

Physical properties of the cross-linked polypentapeptide of tropoelastin are reported along with chemical characterization of key intermediates in its synthesis. 220 MHz proton magnetic resonance spectra are reported on the constituent pentamers and their respective high polymers which verify structural and conformational integrity. Scanning electron microscopy of the cross-linked material formed without orientation and with flow orientation is reported. The former demonstrates the inherent fibrillar and anisotropic nature of the synthetic product. Stress-strain studies show the cross-linked polypentapeptide to exhibit elastomeric properties that are dependent on the water content of the matrix. At high water contents the elastic modulus is less than that of wet native aortic elastin and becomes greater on drying.

Binding Sites↗
PubMed1976

Percutaneous nephrostomy.

A safe and effective method for long-term relief of renal obstruction is presented. This method has been successful in buying time for patients in stiuations in which other approaches are hazardous or more complex. Its use can be modified for short-term therapeutic drainage of the upper urinary tract.

Humans↗
PubMed1976

The etiology of inferior vena caval obstruction and compression.

This review of inferior vena caval obstruction and narrowing centers the discussion on the major groups of diseases which produce primary or secondary obstruction and those which cause distortion or narrowing of the inferior vena cava. Although the majority of these diseases which are involved affect both adults and children, a separate discussion of pediatric causes of inferior vena caval involvement is included. The paper has been organized for discussion by the anatomic areas of potential involvement by disease: the lower, middle, and upper thirds of the vena cava. Other subjects which are covered include a description of the various techniques used for performing inferior vena cavography. A section on the normal anatomy, anatomic variations which may be encountered, and collateral venous pathways is presented. There is also a section on possible pitfalls in interpretation of cavography. The relative value of the vena cavogram in the evaluation of abdominal disease is discussed and the cavogram is compared with other methods of evaluating the retroperitoneum such as arteriography, lymphangiography, excretory urography, and B-mode ultrasonography. Numerous illustrations are included to demonstrate various aspects of inferior vena caval involvement by diseases. Where appropriate, short discussions of the clinical aspects are also included.

Adenocarcinoma↗
PubMed1975

Localised aneurysms of the descending thoracic aorta.

The clinical, roentgenographic and aortographic data were reviewed in 12 patients with localised descending, thoracic aortic aneurysms. The current study indicates that arteriosclerotic peripheral vascular disease not infrequently produced localised saccular aneurysms of the descending thoracic aorta. Characteristic symptomatology was unusual; most aneurysms were detected as incidental roentgenographic findings. The aneurysms projected from the posteroloteral aspect of the aorta and roentgenographically appeared as left hilar masses or left retrocardiac masses when located in the mid and lower descending thoracic aorta, respectively. Specific rim calcification or vertebral erosion was not encountered in any case. During aortography only a small portion of the aneurysm was outlined with contrast material due to partial obliteration of the aneurysmal cavity with thrombus.

Adult↗
PubMed1975

Pneumopericardium associated with bronchogenic carcinoma.

A case of pneumopericardium associated with primary bronchogenic carcinoma is reported. This association between bronchogenic carcinoma and pneumopericardium has not been reported. The roentgenographic features of pneumopericardium are discussed.

Adult↗