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Biomedical subjects

R D Faber

Publications and source records attributed to R D Faber.

6 recordsLinked to original sources

Preparation of leukocyte-poor platelet concentrates via a short, hard spin of a pool of buffy coats.

BACKGROUND AND OBJECTIVES: A new method for the preparation of leukocyte-poor platelet concentrates was developed, based on a short, hard spin of a pool of 5 buffy coats (BCs) combined with automated collection of the platelets. MATERIALS AND METHODS: The characteristics of platelet concentrates (PCs) were studied as a function of the total g force applied to a pool of 5 BCs. Pools of BCs were centrifuged for 1 min with a total g force ranging from about 3,300 to 5,000 gmin (n = 7-9 per applied g force). Deceleration took place without the means of a brake. The total centrifugation time was about 11 min. The platelet-rich plasma (PRP) fraction above the cell layer was separated by an automated component preparation device. RESULTS: A short, hard spin with a total g force of between 3,400 and 4,600 gmin resulted in PCs that contained on average more than 290x10(9) platelets and less than 5x10(6) leukocytes without the use of a leukocyte filter, provided that the transfer of PRP was electronically checked and terminated. The cell concentrations in the PCs are a function of the total g force. Both the platelet and leukocyte levels in the concentrate decreased with an increase in the total g force applied to the pool. CONCLUSION: The preparation of PCs via a short hard, spin of BCs, combined with automated collection of the PRP, may be an alternative method for the preparation of leukocyte-poor PCs.

Blood Component Removal↗

Management of severe vertical dimension problems.

This article illustrates some of the principles and diagnostic techniques that can be used to manage patients with vertical dimension problems. It is paramount to the treatment of these patients to make a proper diagnosis of the problem areas before doing a treatment plan. This involves the use of cephalometric analysis in both the static and the dynamic modes and using orthodontics and surgery to intrude or extrude differently segments or groups of teeth according to the patient's needs. This tends to simplify the treatment and the following of restorative and periodontal procedures.

Adult↗

The differential diagnosis and treatment of crossbites.

The purpose of this discussion was to give the practitioner a better understanding of the diagnostic processes involved in evaluating a crossbite and arriving at a differential diagnosis. It is hoped that the material presented helps to show the logical steps required to arrive at an intelligent diagnosis. The section on appliances was presented to show the range of treatment modalities available and to illustrate specific cases to show their effectiveness. It is important for the practitioner to realize that effective and efficient treatment of the patient must start with a clear diagnostic evaluation of the patient's problem.

Adolescent↗

A cephalometric study of patients with cystic fibrosis.

Children with cystic fibrosis have skeletal maturation and epiphyseal anomalies similar to those in children with nutritional problems. However, these patients have been found to have normal somatic development if treatment is begun early. In a group of children with cystic fibrosis undergoing medical treatment, cephalometric measurements compared favorably with those established by normal standards.

Adolescent↗