Percutaneous salicylate poisoning.
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Biomedical subjects
Publications and source records attributed to R D Ead.
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Serum immunoglobulin levels (IgA, IgM, IgG) were measured by radial immunodiffusion in 57 subjects with varying degrees of alopecia areata. Both IgA and IgM fell with increasing severity of disease as judged by the area of scalp involved. IgM in subjects with extensive disease was significantly lower than that of an age- and sex-matched control group.
Investigation of rare disorders may sometimes help in the understanding of common problems. We describe a patient with an unusual and previously unreported acne-free naevus occurring in an area severely affected by acne. Investigation revealed smaller sebaceous glands, a reduced sebum excretion rate, decreased number of Corynebacterium acnes in the pilosebaceous ducts and a reduced conversion of testosterone to 5 alphadihydrotestosterone in the areas which were free of acne compared with acne-bearing skin. The results of these investigations support some of the suggested mechanisms responsible for the development of acne.
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