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Biomedical subjects

R D Cunningham

Publications and source records attributed to R D Cunningham.

At least 19 recordsLinked to original sources

The medical profile of cataract patients.

The medical profile of patients undergoing cataract extraction is reviewed, documenting preexisting and newly discovered conditions. This article concludes that significant medical conditions exist in this population and the elderly may require the support of facilities for inpatient-based elective cataract extraction despite the trend toward out-patient surgery.

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The red eye. Why it happens, what to do, when to refer.

The ability to differentiate the various causes of ocular hyperemia is important in primary care. Symptoms such as pain, photophobia, and significant blurring of vision usually signify a more serious ocular condition or even a serious systemic disease. The majority of cases can be managed by the primary care physician, but the more serious causes of a red eye deserve prompt recognition and referral to an ophthalmologist to ensure appropriate management.

Conjunctivitis

Fungal-contaminated soft contact lenses.

Examination of clinically seen fungal-contaminated soft contact lenses reveals fungus within the matrix of the lenses in a highly reproductive state. To study the potential hazard of fungal-contaminated soft contact lenses to the cornea, such lenses were placed on abraded corneas of ten rabbits. Sterile lenses were placed on the opposite abraded cornea of each rabbit as a control. Although no fungal keratitis was documented in this experiment, the persistent corneal epithelial disruption seen in seven rabbits, plus the highly reproductive state of the fungus within the lens suggests fungal-contaminated lenses may pose a significant risk to the patient. We recommend prompt replacement of contaminated lenses and instruction of the patient on proper lens hygiene.

Animals

Tobramycin levels in aqueous humor after subconjunctival injection in humans.

Subconjunctival injection of 10 mg of tobramycin provided therapeutic levels in the aqueous humor of 25 patients (ranging in age from 51 to 89 years) who underwent cataract surgery. The absorption from the subconjunctival tissue into the anterior chamber was fairly rapid, reaching a peak in approximately two hours. Peak levels were usually 20 times the minimum inhibitory concentration for Pseudomonas aeruginosa. The drug then gradually disappeared from the aqueous but still exceeded the minimum inhibitory concentration for Pseudomonas organisms after eight hours.

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