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Biomedical subjects

R D Colucci

Publications and source records attributed to R D Colucci.

26 records · Page 2Linked to original sources
PubMed1989

The chemical stability of captopril capsules.

Captopril therapy is effective in the management of congestive heart failure. The development of hypotension, using low or standard doses, frequently precludes many patients from continuing therapy. The use of 1 mg "microdose" captopril capsules has been used for dose titration to avoid complications associated with hypotension. This study evaluated the chemical stability of 1 mg microdose captopril capsules, extemporaneously prepared from commercially available captopril tablets for a period of 60 days which were stored in an amber vial at standard room temperature conditions. Captopril samples were analyzed in triplicate using high pressure liquid chromatographic method on days 0, 30, and 60 following perparation. There was no degradation observed on any of the sampling days. Therefore, the formulation of 1 mg captopril capsules remain stable for a period of 60 days.

Capsules↗
PubMed1989

The compatibility of nicardipine hydrochloride injection with various ICU medications during simulated Y-site injection.

Physical incompatibility studies between an intravenous calcium channel antagonist, nicardipine hydrochloride, and potentially coadministerable ICU medications have been performed. Forty-one medications and four solutions were evaluated. The medications were anesthetic/narcotics, antibiotics, an anticoagulant, a bronchodilator, electrolyte solutions, fluids, H2 receptor blocking agents, steroids and vasoactive agents. Of the forty-five substances, three showed evidence of physical incompatibility as manifested by turbidity, precipitation, or color change. All three were antibiotics. These were ampicillin, ampicillin/sulbactam sodium, and cefoperazone. We conclude that until bioavailability studies are performed these three antibiotics should not be coadministered with nicardipine HCl.

Ampicillin↗
PubMed1988

The effect of various postphlebotomy storage conditions on drug levels.

Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The current study evaluated the stability of eight frequently monitored medications and one of their metabolities, in whole blood and plasma, at 4 degrees C or 25 degrees C, for up to 72 hours. The drugs included antibiotics, a bronchodilator, antiarrhythmics, and an anticonvulsant. Significant changes in drug levels were not identified at the time points studied. Our data suggests that meticulous postphlebotomy handling of blood samples may not be essential to obtain accurate levels of the drugs studied.

Animals↗
PubMed1988

Encainide.

Explore the source record for details and available documents.

Anilides↗
PubMedDate not supplied

Relative variability in bioavailability of oral controlled-release formulations of oxycodone and morphine.

A retrospective analysis compared the coefficients of variation associated with the maximum plasma concentration (Cmax) and the extent of absorption (area under the curve [AUC] from 0 hour to the last observation) for oral, controlled-release tablet formulations of oxycodone (OxyContin) and morphine (MS Contin). Data from fasting, male subjects aged 18 to 45 years were taken from five controlled-release oxycodone (N = 82) and seven controlled-release morphine (N = 101) single-dose, bioequivalence studies. The coefficients of variation of Cmax and AUC were approximately 33% less for controlled-release oxycodone than for controlled-release morphine (P =.005). The variation from the minimum to maximum value was two to three times less for controlled-release oxycodone than for controlled-release morphine. Among healthy male subjects, the absorption of oxycodone from oral controlled-release oxycodone was significantly more consistent than the absorption of morphine from oral controlled-release morphine in terms of both maximum absorption and extent of absorption.

Adolescent↗