Biomedical subjects
R D Coffin
Publications and source records attributed to R D Coffin.
High-performance liquid chromatographic determination of ascorbic acid in urine: effect on urinary excretion profiles after oral and intravenous administration of vitamin C.
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Determination of disaccharides in feces by permethylation and gas chromatography: rapid screening for carbohydrate intolerance in children.
Disaccharides can be identified and determined quantitatively in fecal specimens by permethylation of the components in crude supernatants followed by isothermal gas chromatographic separation on OV-17 columns. The method provides a rapid screening procedure for detecting patients suspected of having a carbohydrate intolerance secondary to intestinal disaccharidase deficiency.
Artifacts in the gas chromatographic analysis of some sulfur-containing amino acids.
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Comparative circulatory effects of adrenaline and noradrenaline during intra-osseous dental anaesthesia.
The effects of intra-osseous dental anaesthesia on heart rate and blood pressure was examined in 17 healthy volunteers. Adrenaline containing anaesthetic solutions were accompanied by increased heart rate and elevated systolic blood pressure which were not acceptable to a high proportion of subjects. Noradrenaline at the same concentration as adrenaline (1/80 000) usually decreased the heart rate and elevated the blood pressure. A few subjects experienced a feeling of weakness in the lower extremities when noradrenaline was injected. Endogenous catecholamine formation in these test conditions gave rise to insignificant circulatory effects.