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Biomedical subjects

R Curtis

Publications and source records attributed to R Curtis.

At least 127 records · Page 7Linked to original sources
PubMed1982

Hereditary luxation of the canine lens. Animal health trust small animals centre, newmarket.

Primary lens luxation is the most common form of lens displacement encountered in the dog in the United Kingdom. The condition arises in early to late middle age, is essentially bilateral and occurs typically in the terrier breeds. Subluxation is rarely observed before 3 years of age but luxation of the lens is ultimately almost invariable. In Tibetan Terriers bred for the condition zonular changes were evident at least as early as 14 months of age. The condition could serve as a model for late spontaneous dislocations of the lens in man.

Age Factors↗
PubMed1982

Subtalar dislocation of the foot.

We studied a series of seventeen cases of subtalar dislocation of the foot. There were on anterior, twelve medial, and four lateral dislocations. Of the seventeen dislocations, fourteen were closed and three, open. Two of the four lateral dislocations were open. Associated fractures involving the talocalcaneal or talonavicular joints were noted in eight feet, including three of the four with a lateral dislocation. In two feet these fractures were noted only on post-reduction polytomography. Associated fractures of the ankle mortise and of the metatarsals were present in seven feet. Associated fractures involving the subtalar or talonavicular joints, open dislocations, and associated injuries requiring immobilization of the foot for more than three weeks produced poor results due to pain and limitation of subtalar motion. Lateral dislocations were particularly prone to poor results, due to the frequency of open injuries and associated fractures. Cast immobilization for three weeks and early range-of-motion exercises of the subtalar joint are recommended for the best results.

Adolescent↗
PubMed1981

Canine adenovirus-induced ocular lesions in the Afghan hound.

A series of referred cases of CAV-1-induced ocular disease suggested increased susceptibility of the Afghan Hound. Of a litter of Afghan Hound puppies inoculated with a commercial vaccine containing attenuated CAV-1, three developed corneal edema and the litter as a whole showed marked febrile and serological responses to the virus. Under experimental conditions Afghan Hounds inoculated with CAV-1 at two levels of attenuation showed more profound clinical responses than Beagles receiving similar inocula. An enhanced generalized susceptibility to infection is suggested as a possible explanation for the greater incidence of CAC-1-induced ocular lesions in this breed.

Adenoviridae↗
PubMed1979

Genetic aspects of lens luxation in the Tibetan terrier.

Analyses were undertaken of 20 cases of lens luxation in British-bred Tibetan terriers, together with a further seven from Sweden. General proband segregation tests showed that the data were consistent with a simple autosomal recessive hypothesis (P = 0.152 +/- 0.0563). This was supported by high levels of inbreeding ranging from 0 to 24.3 per cent, with a mean of 14.3 per cent (SD 5.32 per cent). All affected cases traced back to one or more of three animals (born mid 1950s) on both sides of their pedigrees, all three being breed champions. Inclusion of data from repeat litters between presumed heterozygous animals gave a ratio of 25 lens luxation cases in 121 progeny, which again supported the same genetic theory. The age at onset (three to five years) mitigates against test mating of animals within the breed.

Animals↗
PubMed1978

Kinetics of methotrexate uptake by human tumor cells from routine pathological samples.

The kinetics of cell uptake of methotrexate were measured in vitro using primary human tumor cells from malignant pleural effusions, leukemic cells from leukopheresis samples, and normal tonsillar lymphocytes. The results were consistent with either passive diffusion or carrier mediated uptake kinetics, with the latter applicable only under conditions where the extracellular concentration of methotrexate was smaller than the drug-transport receptor binding constant. The intial rates of uptake for the same cell type differed signicantly between patients; however no differences in uptake rates were noted between cell types. All three sources of cells proved suitable for uptake studies. The results suggest that the variation in response in normally methotrexate responsive neoplasms, such as leukemia or lymphoma, may be due to between-patient differences in the cellular rates of methotrexate uptake.

Adolescent↗