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Biomedical subjects

R Cruz-Coke

Publications and source records attributed to R Cruz-Coke.

At least 55 records · Page 3Linked to original sources
PubMed1987

Correlation between prevalence of hypertension and degree of acculturation.

Epidemiological evidence indicates that the development of hypertension in human populations depends on the interaction of a genetic heterogeneity and multiple environmental factors. The purpose of this research is to demonstrate the hypothesis that the rise of prevalence of hypertension in developing countries is real and associated with the influence of environmental factors created by the process of 'acculturation'. I have studied all reported prevalence rates of hypertension in Chile between 1936 and 1984. Data from 31 studies in urban and rural populations were correlated to demographic markers of acculturation, life expectancy at birth and urbanization trend (%). Results showed that during this period life expectancy rose from 40 to 67 years and urbanization trend from 51 to 80%. These correlated with the secular increase in the prevalence of hypertension, from a 5% level to almost a 20% level. The study of the cultural breakdown of six rural isolated populations showed after a mean of 15 years a highly significant increase in hypertension prevalence from 1.5 to 7.5%. These positive findings support the hypothesis that the change in prevalence of hypertension in the Chilean population during half a century may be associated with the process of cultural transition to an industrial state.

Acculturation↗
PubMed1985

Cardiovascular diseases in Chile.

In 1938, Chile became the first developing country to establish a state health system for the prevention of cardiovascular diseases (CVD). Although prevalence of CVD risk factors (smoking, high cholesterol and triglycerides, hypertension, and atherosclerosis) is lower than in industrialized countries, over the last 50 years CVD incidence in Chile has increased considerably. Cardiovascular disease is diagnosed in 25% of outpatients in departments of the National Health Service. Hypertension is the first cause of morbidity among the adult population (10%). Between 1960 and 1980, CVD mortality increased from 14 to comprise 27% of all deaths. Age-specific mortality for ischemic heart disease increased during the same period from 407 to 699 per 100,000 population. Surveys of the general adult population showed a prevalence of hypertension of almost 20%. Community hypertension follow-up programs obtained only 50% compliance, and blood pressure was normalized in only one-third of hypertensive patients. It is probable that the low standard of living may have influenced the poor results of prevention programs.

Adult↗
PubMed1982

Pure XX gonadal dysgenesis in identical twins.

Pure gonadal dysgenesis has been described in several sibships. We report a pair of monozygous twins and their younger sister with secondary amenorrhea. They had no associated congenital anomalies. Plasma FSH levels were elevated and the ovarian biopsies showed absence of follicular structures. Their karyotypes were 46XX, further supporting the concept that his form of familial gonadal dysgenesis is an autosomal recessive defect.

Adult↗