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Biomedical subjects

R Cox

Publications and source records attributed to R Cox.

At least 235 records · Page 13Linked to original sources
PubMed1976

Inferior-border rib grafting for augmentation of the atrophic edentulous mandible.

Use of inferior-border grafting eliminates many of the problems associated with transoral onlay graft procedures. With an inferior-border graft, the graft does not bear the direct pressure of a prosthesis and allows for increase in mandibular height without as much loss of vestibule as in a transoral graft. A skin-graft vestibuloplasty is performed 6 to 12 months after rib grafting but the patient can wear a denture in the interim.

Adult↗
PubMed1976

Effect of N-methyl-N-nitrosourea on the DNA of rat bladder epithelium.

Bladder cancer can be induced in the rat by the intravesicular administration of N-methyl-N-nitrosourea. DNA damage in rat bladder epithelial cells after administration of methylnitrosourea has been examined by measuring the change in sedimentation of the DNA in alkaline sucrose gradients. A dose response of DNA damage in the urothelium was observed with single intravesicular doses of 0.1, 0.3, and 0.5 mg of methylnitrosourea. Larger doses of methylnitrosourea damaged the epithelium so extensively, that biochemical studies were not feasible. DNA repair, measured by the return to a normal sedimentation pattern of DNA on alkaline sucrose gradients, was followed over a period of 9 days with the use of 0.5 mg of methylnitrosourea to initiate the damage. Bladder epithelial cells were able to repair the DNA damage induced by methylnitrosourea. However, the possibility of persistent damage not detectable by sedimentation of DNA on alkaline sucrose gradients cannot be ruled out.

Animals↗
PubMed1975

Damage and repair of DNA in various tissues of the rat induced 4-nitroquinoline 1-oxide.

4-Nitroquinoline 1-oxide induces pulmonary tumors when given by a s.c. route or skin cancer by repeated local applications. This carcinogen is absorbed by the lung more readily than other tissues. Therefore, we have compared the ability of 4-nitroquinoline 1-oxide to damage DNA of the liver, lung, and kidney in the intact animal. A differential effect of DNA damage was detected in all three organs, with the lung showing the greatest amount of damage. All three tissues were able to repair the damaged DNA. The preferential damage of rat lung DNA by 4-nitroquinoline 1-oxide correlates with the specificity of this carcinogen to induce pulmonary tumors.

Animals↗