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Biomedical subjects

R Coulson

Publications and source records attributed to R Coulson.

45 records · Page 3Linked to original sources
PubMed1971

Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma.

A patient with a multiple-hormone-producing islet cell carcinoma, who had previously been successfully treated with streptozotocin, was given three further infusions of this drug because of the redevelopment of gastric hypersecretion. Although some evidence of damage to the gastrinsecreting cells was obtained, the fasting plasma gastrin was not significantly altered and the patient died from a perforated duodenal ulcer. Serum insulin levels were considerably reduced and the patient became mildly diabetic but the main complication of treatment was a severe though reversible renal tubular defect. At necropsy considerable quantities of gastrin, but low levels of insulin and glucagon were extracted from a tumour metastasis.

Acetoacetates↗
PubMed1970

Clinical and metabolic study in diabetic patients treated with glibenclamide.

A clinical and metabolic study of 32 patients treated with glibenclamide for a period of about one year confirmed that the drug is a potent stimulator of insulin release in maturity onset diabetes, and glibenclamide continued to have this action after a period of eight months. The drug is effective in doses as low as 2.5 mg., and the maximum effective dose is about 15 mg. No significant side-effects were found during the period of the study, in particular there was no alcohol flushing. The metabolic investigations have shown that the drug has some actions which are as yet unexplained.

Adult↗
PubMed1967

Hyperpyruvaturia in experimental diabetes.

1. The 24 hourly excretion of pyruvate and glucose has been measured in alloxan-diabetic rats.2. The animals were allowed a 6-day control period before being injected with alloxan (I.V. 50 mg/kg body weight). The diabetes was treated by daily injections of insulin for a period of 6 days from the 7th to the 12th day following the alloxan injection.3. The pyruvate excretion increased more than 5-fold following the induction of diabetes, the values being 189 +/- 130 (S.D.) mug/24 hr in the control period rising to an average of 1002 +/- 664 (S.D.) mug/24 hr over the first 6 days of diabetes. The administration of insulin over the second 6-day period of diabetes caused the pyruvate excretion to decrease-though not significantly. Upon the withdrawal of the insulin treatment the pyruvate excretion increased significantly from 785 +/- 315 (S.D.) mug/24 hr to 2105 +/- 679 (S.D.) mug/24 hr, measured over a 5-day period. The final period of pyruvate excretion was significantly greater than the excretion over the first diabetic period.4. The glucose excretion during the initial diabetic period was 6.75 +/- 2.64 (S.D.) g/24 hr. The administration of insulin caused a 42% decrease in glucose excretion compared to a decrease of 22% for the pyruvate. The withdrawal of insulin caused the glucose excretion to increase by 149% while the pyruvate excretion increased by 157%.5. Diabetes was also induced temporarily by injections of anti-insulin serum and diazoxide. In each case significant glycosuria and hyperpyruvaturia were produced.6. The possible causes of the hyperpyruvaturia in diabetes are discussed.

Animals↗
PubMedDate not supplied

Revitalizing the General Practice Research Database: plans, challenges, and opportunities.

The General Practice Research Database (GPRD) is the world's largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool. Several issues have threatened the viability of the database in recent years; in April 1999 responsibility for its management and financial control was transferred to the UK Medicines Control Agency (MCA). This presentation outlines the MCA's plans and future vision for the GPRD.

Data Collection↗