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Biomedical subjects

R Costa

Publications and source records attributed to R Costa.

At least 163 records · Page 9Linked to original sources
PubMed1987

Effectiveness of pinaverium bromide in the treatment of primitive biliary dyskinesia: 99mTc-P-IDA scintigraphic evaluation.

The 99mTc-P-IDA (technetium-p-iminodiacetic acid) hepatocholangiocholecystoscintigraphy is a diagnostic technique which allows information on the liver biligenetic and excretory capabilities to be obtained. It is, moreover, a test that mirrors closely the anatomic and functional conditions of the cholecyst and choledochus. In this study the authors wanted to verify whether pinaverium bromide, a drug with a documented musculotropic-spasmolytic activity, was able to induce changes in some abnormal instrumental parameters observed in 24 subjects with primitive biliary dyskinesia. The results revealed that the ti values, characteristically longer in those subjects, were significantly reduced in the group of patients treated with pinaverium bromide. On the contrary, in the group of patients treated with placebo, there was no change with respect to this parameter.

Adult↗
PubMed1986

[Quebec's population decline: if it is foreseeable, is it avoidable?].

"Quebec's fertility is the lowest in Canada, and it is most likely that its population is heading for a decline. In this paper, the authors try to make explicit some of the scenarios which could prevent this decline. They first briefly present the current trends and specify the assumptions used in the simulation. Then, they analyse the results by investigating the onset of the decline and the maximum size of the population. And finally, they present some of the replacement scenarios which may prevent the decline." (SUMMARY IN ENG AND SPA)

Americas↗
PubMed1984

Evaluation of an ultrafiltration-fluorescence polarization immunoassay for monitoring unbound phenytoin.

To evaluate a new ultrafiltration-fluorescence polarization immunoassay (FPIA) for monitoring blood levels of unbound phenytoin, the drug, with or without a 14C label, was added to three serum pools obtained from normal, uremic, and hypoalbuminemic patients and to 10 individual patient sera that varied greatly in phenytoin binding (11-50%). Protein-unbound phenytoin fractions were obtained from the sera by ultrafiltration using the Amicon Micropartition System and by a classic equilibrium dialysis method. The percent unbound phenytoin in each serum was determined by a radioassay and an automated FPIA (TDx System). An analysis of variance revealed no significant difference in the percent unbound phenytoin obtained at 37 degrees C by the FPIA and radioassay methods (alpha = 0.05). The data indicate that the ultrafiltration system can be combined with FPIA to produce a convenient laboratory method for routine therapeutic drug monitoring that gives results comparable to the equilibrium dialysis, radioassay reference method.

Blood Protein Disorders↗
PubMed1983

Esterase-6 allozymes: biochemical studies of two common and one rare variant in Drosophila melanogaster.

The biochemical properties of three allozymes coded by the Est-6 locus, two common forms (EST-6S and EST-6F) and one rare form (EST-6VF), were studied. The results show the existence of differences in isoelectric point, activity, activation energy, Km, and temperature coefficient among the three variants, especially between the two common forms and the one rare form. The specific activity of the rare enzymatic variant seems to be less affected by temperature variation. The possible significance of these findings in relation to the mechanism of reproduction is briefly discussed.

Alleles↗