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Biomedical subjects

R Costa

Publications and source records attributed to R Costa.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Adoptive immunotherapy of advanced solid tumors: an eight year clinical experience.

BACKGROUND: Adoptive immunotherapy (AI) of cancer, based upon the injection of in vitro manipulated autologous lymphocytes is still in an experimental phase. Our group started different clinical trials of AI in early 1990, and, at present, some specific targets for this approach seem to have been identified. PATIENTS AND METHODS: 296 patients with solid tumors (melanoma, kidney carcinoma, non-small-cell lung cancer, mesothelioma, neoplastic pleural effusion, and liver cancer) were treated with either locoregional or systemic adoptive immunotherapy (AI) using both LAK and TIL cells in combination with s.c. rIL-2. RESULTS: The surgery/AI combination resulted in good clinical results, characterized by enhanced survival and long lasting disease free periods in a significant number of patients. CONCLUSIONS: AI seems to be efficacious in the treatment of melanoma, lung and hepatic cancers. Further studies will expand the application of the treatment to other malignancies.

Clinical Trials as Topic↗
PubMedDate not supplied

[Gastric emptying after duodenogastric resection].

The gastric emptying has been studied with 99Tc labelled in 35 patients followed for 2-8 years after duodenogastric resection. All patients had been undergone a gastric resection of 2/3 of stomach. In 18 had been performed a Billroth II (BII) and in 17 a gastrojejunostomy with a Roux-en-Y anastomosis. The jejunal loop had been carried out about 25-35 cm from the Treitz, the mesenteric margin isolated for 2-3 cm and the jejunojejunostomy performed about 50 cm from the gastrojejunostomy. Nobody complained symptoms from altered gastric emptying. In all patients with Roux-en-Y anastomosis there was an intense radioactivity in the new stoma till the 150th minute, and peristaltic activity was valid and coordinated. In patients with BII there was no radioactivity in the new stoma before the 150th minute, and peristaltic activity was always convulsive and uncoordinated.

Adult↗
PubMedDate not supplied

[Study of esophageal transit with radioisotopes in the diagnosis of achalasia].

The investigations employed in the diagnosis of oesophageal achalasia have been assessed critically. Although electromanometry contributes most to diagnosis and pinpoints with absolute precision the physiopathological elements that characterise the disease, radioisotopic study of oesophageal transit is an important diagnostic aid. More readily than any other, this technique permits morphofunctional evaluation in selected patients; it also represents the most physiological investigation and the best tolerated and, second only to manometry, the most reliable. Oesophagography with baritate meal and oesophagoscopy also play a diagnostic role in oesophageal achalasia. The former makes it possible to document the cardial stop and the presence or otherwise of mega-oesophagus, the second excludes the presence of organic dysphagias and also has a therapeutic use because cycles of dilatation of the oesophago-cardial junction can be carried out.

Esophageal Achalasia↗
PubMedDate not supplied

[Protirelin in the treatment of cerebrovascular disorders].

Effects of protirelin tartrate, administered for 14 days (2 mg/day, i.m.) to 15 patients with acute cerebrovascular disease have been investigated. The evaluation was performed by means of SPECT, at enrollment and at the end of treatment. This evaluation was aimed at the early detection of ischemic damage and assessment of the size of the hypoperfusion area. Treatment with protirelin tartrate was well tolerated and led to definite improvement of the scintigraphic findings in about 74% of the patients.

Acute Disease↗
PubMedDate not supplied

The De Vega annuloplasty as surgical treatment for tricuspid incompetence.

Seventy-six patients with tricuspid insufficiency associated with other valvular lesions underwent De Vega annuloplasty. There were mitral lesions in 74 patients, aortic valve lesions in eight and atrial septal defects (ASD) in four. The radiographic and electrocardiographic findings and hemodynamic data are reported for 66 patients. Replacement of one or two valves was performed in 56 patients, one or two valves commissurotomy in 21 and closure of the ASD in four. The immediate postoperative mortality was 19.7%. Forty-four patients were followed from six to 59 months. There were three late deaths and clinical conditions were improved in all the survivors except one who presented mitral restenosis. Discrete residual tricuspid incompetence occurred in 11 patients (25%). We conclude that the De Vega annuloplasty is the treatment of choice for functional tricuspid incompetence.

Adolescent↗