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Biomedical subjects

R Conti

Publications and source records attributed to R Conti.

88 records · Page 5Linked to original sources
PubMedDate not supplied

Rifampin therapy for brucellosis, flavobacterium meningitis, and cutaneous leishmaniasis.

Rifampin has a broad antibacterial spectrum. At high concentrations it also is active in vitro against protozoa, i.e., different species of Leishmania. Rifampin has been used against bacterial and occasionally protozoal infections. Addition of rifampin to a tetracycline regimen was found to reduce the number of relapses in patients with acute and chronic brucellosis. In a few cases of meningitis due to Flavobacterium meningosepticum, which failed to respond to other drugs, patients were treated successfully with rifampin administered either orally or intravenously. Rifampin at doses of greater than or equal to 600 mg daily has been administered to patients with cutaneous leishmaniasis. Healing of skin lesions was observed in the majority of treated patients. Controlled studies are needed to assess the usefulness of rifampin in this disease.

Brucellosis↗
PubMedDate not supplied

Electrophysiological study on jaw-opening reflex recorded from digastric muscle in Parkinson's disease and primary cranial dystonias.

We investigated digastric reflex excitability in normals and in patients with extrapyramidal disorders such as primary cranial dystonias and Parkinson's disease. Relationships between exteroceptive suppression of masseter muscle and digastric reflex were also investigated in some cases. Digastric reflex hyperexcitability was observed in dystonic patients when compared to normals and parkinsonian patients. Furthermore, some patients with cranial dystonia presented absence of exteroceptive suppression reflex in masseter muscle with enlarged digastric response. These results indicate hyperexcitability of the digastric reflex and abnormal agonist-antagonist muscle co-contraction in chewing reflexes of patients with cranial dystonias. This shows that digastric reflex is an important electrophysiological investigation to explore the physiopathological mechanisms of primary cranial dystonias.

Aged↗
PubMedDate not supplied

Monoclonal antibodies recognizing a recombinant portion of human alpha-fetoprotein with antigenic selectivity versus albumin.

Determination of serum alpha-fetoprotein is useful in the clinical management of liver cancer, but it has not been particularly helpful in the early diagnosis of this disease, since also non-neoplastic liver diseases may result in small increases of its serum concentration. To improve the clinical performance of this assay, we have previously developed an in vitro culture system, in which the expression of alpha-fetoprotein and albumin could be coordinately modulated by thyroid hormone. This system allowed large scale production and purification of native alpha-fetoprotein to be used as reference material. In addition, we synthesized and cloned in a bacterial expression vector a DNA sequence coding of human alpha-fetoprotein amino acid sequence 38-119. This alpha-fetoprotein sequence was chosen since it is the least homologous to albumin, being the amino acid sequence of the two proteins extremely similar with an overall identity of about 38%. Now we have obtained three hybridomas recognizing with high affinity and specificity both the recombinant fragment and native alpha-fetoprotein. These antibodies, which therefore recognize the native protein in the amino acid sequence 38-119, should allow the development of an immunoassay for alpha-fetoprotein with absolute selectivity versus albumin. This might result in more sensitive clinical determinations, avoiding the possibility of cross-reactions.

Albumins↗
PubMedDate not supplied

For an elective surgical management in lumbar intervertebral disc herniation. Experience of 25 years of surgery.

On the base of a wide clinical experiences, the Authors report some consideration about relationship between clinical findings and neuroradiological pictures (plain film, myelography, CT and NMR) of the lumbar vertebral and disc diseases. It's pointed out the useful aspect of each imaging technique that contribute to obtain the more complete informations about anatomy of the lesion; such considerations allows the surgeon to plain the more adequate surgical technique. The Authors think myelography, still today, is the investigation of choice in this kind of pathology.

Adult↗
PubMedDate not supplied

Surgical treatment of vertebro-epidural neoplasms of the cervical tract via the anterior approach.

Fifteen cases of vertebral-epidural neoplasms of the cervical tract, treated surgically by the technique of longitudinal median somatotomy with inlay arthrodesis via the anterior approach are presented. Compression of the spinal anterior artery is eliminated by the wide anterior longitudinal exposition, which also creates a support for a possible second operation, either laminectomy or foraminotomy.

Adolescent↗
PubMedDate not supplied

Observations on some rare cases of vertebro-medullar malformations associated with tumors.

Three cases of complex vertebro-medullary malformations of the diastematomyelic type associated with dysembriogenetic tumors are presented. In the first case, a true diastematomyelia, associated with a teratoma of mixed histological structure, is described. In the second and third cases, diplomyelia associated with an epidermoid and a dermoid cyst respectively are reported.

Adult↗
PubMedDate not supplied

Multiparametric quantitative evaluation of the speech production system: a study in normal subjects.

This paper describes a systems architecture developed for the study of the speech production system. The architecture utilizes two personal computers: the "Word-Image Presenter" (WIP) that presents a sequence of words to the subject under examination as visual stimulation, and the "Signal Acquisition System" that controls the WIP, acquires the acoustic signal, the oromandibular electromyographic signals, the kinematic lip and jaw signals and measures reaction times and durations. Thirty normal subjects divided into three age groups (18-44, 45-59, 60-80) underwent examination by means of the described system. During the test a random sequence of two words was presented to the subjects; the protocol consisted of an immediate reading task and two delayed reading tasks with variable foreperiods of 0.1 and 1.5 s for one task and 0.5 and 4 s for the other. The analysis of the resultant acoustic and electromyographic signals indicated that reaction times increased with age in both the immediate and delayed tasks. The analysis of variance showed that the difference between the young and elderly groups was statistically significant. The sample size of the groups, however, is too small to consider these results normative data.

Adolescent↗
PubMedDate not supplied

[Care of skin infections in patients in peritoneal dialysis].

The incidence of exit-site infections among peritoneal home-dialysis patients was quantified following for 1 year all home dialysis patients of 23 dialysis centres. The exit site conditions were observed and classified according to Twardowsky. When an infection occurred data on its treatment were collected. 393 patients were observed. The infection occurred in 40 patients (10.1%). 82.2% of patients wear a Tenckoff catheter, 3% do not protect the exit site with any kind of dressing. The strategies adopted by different centres vary for the choice of antiseptics, the suggested frequency of changes dressing and the routine use of nasal swabs. Due to the limited number of patients with infection no association was found between tunnel direction or frequency of dressing changes and infections occurrence. Discussion on controversial aspects and the definition of common guidelines for instance for frequency of dressing changes, use of antiseptics is warranted.

Adult↗
PubMedDate not supplied

[Hepatic steatosis: clinical-statistical study of patients diagnosed by histological or ultrasonographic methods].

PURPOSE: This study wants to document eziopathogenetic factors and clinical, instrumental and hystological characters that associate to the various types of hepatic steatosis. PATIENTS AND METHODS: In this retrospective study have been examined two different groups of randomized patients. The "Group 1" comprehended 70 patients with hystologic diagnosis of hepatic steatosis (steatohepatitis--SH--60%; steatosis--SE--40%). The "Group 2" comprehended 70 patients with ultrasonographic pattern of fatty liver (slight degree: 70%; severe degree: 30%). RESULTS: Analysis of results relative to the "Group 1" showed the role of HCV-infection in etiopathogenesis of the SH, significantly greater than in SE (76.2% vs 25%; p < 0.0001). SE is often associated with exogenous noxae (alcoholism: 28.6%; use of long-term medications: 14.3%) or metabolic disorders (hyperglycemia 28.6%, hyperlipidemia 42.8%, obesity 25%). Haven't seen differences of clinical data or serum liver tests between SE and SH. Histological features that predicted the development of cirrhosis and/or fibrosis are more frequent in SH (SH: 40.4% vs SE: 10.7%; p < 0.01). The analysis of "Group 2" hasn't shown differences of clinical data or serum liver tests between slight and severe degree. CONCLUSIONS: Analysis of results relative to the two groups of patients ones has shown that SE and SH are thick asymptomatics and associated at hepatomegaly and at increase of ALT, AST, gamma GT. The increase of ALT and/or AST leads to search for the markers of HBV and HCV; when they are positive, hepatobiopsy is necessary for the diagnosis of possible SH or evolutive state to liver cirrhosis.

Acquired Immunodeficiency Syndrome↗