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Biomedical subjects

R Chandra

Publications and source records attributed to R Chandra.

At least 163 records · Page 9Linked to original sources
PubMed1985

Small left atrium and change in contour of the ventricular septum in total anomalous pulmonary venous connection: a morphometric analysis of 22 infant hearts.

Morphometric measurements of 22 hearts with total anomalous pulmonary venous connection (TAPVC) were compared with measurements of 8 matched control specimens without heart disease. Each of the TAPVC specimens had a shorter left atrium, smaller left atrial surface area and larger diameter of the fossa ovalis. In addition to increased length of the right ventricle and larger circumferences for tricuspid and pulmonary valve anuli, the left ventricular contour of the ventricular septum was flat or convex in 18 of the 22 hearts; the septum was significantly longer than normal in these specimens and wider at its midportion. Because mitral and aortic valve anuli were normal in circumference, the data suggest that left ventricular volume is not decreased despite change in ventricular shape.

Heart Atria↗
PubMed1985

Studies on pathogenesis of buffalo pox virus in rabbits: quantitative assay of virus in different organs.

The buffalo pox virus was found to multiply in the skin, the primary site of inoculation with an eclipse phase of 12 hr. The virus was then detected in the skin after 15 hr followed by its appearance in regional lymph nodes 36 hr postinoculation. Primary viremia was detected 48 hr postinoculation, followed by detection of virus in the lungs, liver, and spleen. The virus multiplied in the lungs on day 4 and in the liver and spleen on day 5 postinoculation and its release led to secondary viremia. In a follow-up from day 7 to 14 postinoculation, the virus was detected in the kidneys, stomach, intestines, and gonads.

Animals↗
PubMed1985

Malignant thoracopulmonary small-cell ("Askin") tumor.

The clinical, radiographic, and pathologic features of 10 patients with documented malignant small-cell tumor of the thoracopulmonary region (Askin tumor) were reviewed. The tumor represents a distinct pathologic entity of neuroectodermal origin. Clinically, it presents as a chest-wall mass with or without pain. Its radiographic appearance is that of a soft-tissue mass with or without pleural or rib involvement, often with metastatic disease--to the skeletal system, bone marrow, thorax, and sympathetic chain. Two patients developed metastases to the adrenal gland and liver, one after autologous bone marrow transplantation. The radiologist should be aware of this entity and its pattern of metastatic spread since metastases are treated aggressively.

Adolescent↗
PubMed1985

Trilateral retinoblastoma: ocular and pineal retinoblastomas.

Trilateral retinoblastomas, the syndrome of bilateral retinoblastoma associated with ectopic retinoblastoma in the pineal gland, is rare but well recognized. In contrast to bilateral retinoblastomas alone, the ocular retinoblastomas in trilateral retinoblastoma develop before the age of 6 months, and a family history positive for retinoblastoma is usually obtained. The retinal tumors are often quiescent at the time that the pineal tumor is discovered, and show no evidence of metastatic spread after enucleation of the globes. Pathologically, the pineal tumor is indistinguishable from the ocular retinoblastoma. The pathophysiology of this syndrome is not well understood, but a germinal mutation is thought to target photoreceptor tissue for further postzygotic mutation. Eventual expression depends on the inherited host resistance to the carcinogenic manifestation of these genes. The low host resistance of trilateral retinoblastoma is evident by the early age of presentation, the multicentric occurrence of the tumor, and the high early mortality rate despite aggressive management.

Brain Neoplasms↗
PubMed1985

Pathogenesis of buffalo-pox virus in buffalo calves.

Pathogenesis of buffalo-pox virus (BP4 strain) in buffalo calves following intradermal inoculation revealed bimodal thermal reaction. The prominent symptoms were lacrimation, mucoprulent nasal discharge and diarrhoea. The typical pook lesions produced in the skin were passed through reseolar, papular, vesicular, pustular and desquamative stages of infection followed with a second rash, between day 6-8 on the lips, tongue, neck, perinium region and around the nostrils and eyes. After the eclipse phase of 10 hours, the concentration of the virus started increasing logarithmically. Thereafter, the virus was subsequently detected in the regional lymphnode, blood stream and central organs viz., lung, liver & spleen on 2nd, 4th and 5th day, respectively. In blood stream the virus was found to be associated with white blood cells. Secondary viremia was again on day 6 post-inoculation. Gross and microscopic changes were observed in these organs. The presence of virus along with pathologic changes were also detected in stomach and intestine. The disease ran a course of 13 to 15 days.

Animals↗
PubMed1985

Detection of herpes simplex infection in cytologic smears.

We compare the results of direct immunofluorescence (IF) with cytology (Papanicolaou's stains) for diagnosis of herpes simplex infection. Thirty smears were examined. Yellow-green fluorescence was seen in 17 smears. Only eight of these smears had diagnostic cytology, and nine of the smears with positive fluorescence had none (four) to minimal (five) cytologic changes, suggesting that direct IF is a much more sensitive method for diagnosis of herpes simplex infection in cytologic smears.

Cytodiagnosis↗
PubMed1984

Chronic lymphadenopathy due to mycobacterial infection. Clinical features, diagnosis, histopathology, and management.

This report provides clinical information, diagnostic criteria, management, and outcome of 153 cases of mycobacterial lymphadenitis; 22 patients (14%) had Mycobacterium tuberculosis (TB) and 131 patients (86%) had nontuberculous mycobacterial (NTM) disease. Correct diagnosis of TB v NTM disease is essential, since antituberculous chemotherapy was effective for TB adenitis, while excisional biopsy was the treatment of choice for NTM adenopathy. Dual (PPD-NTM, PPD-T) Mantoux tests discriminated between TB and NTM adenitis in 151 (99%) of 153 patients, while dual (PPD-Battey [B], PPD-T) tests differentiated between NTM and TB adenitis in 135 (88%) of 153 cases. A PPD-T reaction of 1 to 14 mm suggested either an NTM or TB infection, whereas a PPD-T of 15 mm or greater was strongly associated with TB disease. We recommend the use of PPD-B and PPD-T antigens as reliable diagnostic discriminators between TB and NTM adenitis.

Antitubercular Agents↗
PubMed1984

Intraosseous schwannoma: histologic features, ultrastructure, and review of the literature.

Intraosseous schwannoma, a rare benign neoplasm, has a characteristic radiographic appearance. The histologic features, although similar to those of soft tissue schwannomas, may be obscure when the lesions are highly cellular and the Antoni Types A and B patterns are subtle. Four additional cases of intraosseous schwannoma are presented, with ultrastructural studies from two tumors, one of which was highly cellular and presented a diagnostic problem. The ultrastructural features of intraosseous schwannomas have not been documented previously; however, the findings are essentially the same as those observed in soft tissue schwannomas. The radiographic, histologic, and ultrastructural findings in the cases reported are discussed in relation to published data for intraosseous and soft tissue schwannomas. The authors propose that the comparatively high frequency of mandibular involvement by intraosseous schwannoma may be related to the fact that schwannomas, in general, arise most frequently in the head and neck regions. Furthermore, since schwannomas arise mainly in association with sensory nerves, probably the dearth of such fibers within bone accounts for the rarity of intraosseous schwannoma.

Adolescent↗
PubMed1984

Tracheal tube cuff pressure. Changes during nitrous oxide anaesthesia following inflation of cuffs with air and saline.

The volume and pressure of a tracheal tube cuff inflated with air increases during nitrous oxide anaesthesia. The study was designed to investigate the changes of tracheal tube cuff pressure during nitrous oxide anaesthesia following inflation of the cuff with air or saline in 10 mongrel dogs who were anaesthetised with nitrous oxide and their lungs artificially ventilated. At the end of 6 hours there was no change in cuff pressure when saline had been used for inflation, but was six times the initial pressure when air had been used. On microscopic examination of the trachea, only the air group had glandular inflammation, dilatation and destruction. Therefore, it appears that if saline is used to inflate tracheal tube cuffs, there will not be an increase in cuff volume and pressure during nitrous oxide anaesthesia.

Anesthesia↗