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Biomedical subjects

R Centor

Publications and source records attributed to R Centor.

2 recordsLinked to original sources

Stochastic thresholds.

Thresholds have traditionally been represented by a single number; the optimal management of the patient depends on whether his probability of disease is above or below this number. The concept of a threshold as a single number, however, inadequately represents the treatment approach of a group of physicians who do not have all the same threshold or a single physician who is uncertain about the exact value of the threshold. An alternative to a single valued threshold is to consider the threshold as having a probability distribution: for every probability that the patient has the disease there is a probability that the threshold is exceeded. This "stochastic" threshold model contains information about the uncertainty of the threshold estimation. Stochastic thresholds can be useful for testing the sensitivity of a management decision to the patient's probability of disease. They can also be used for comparing the standards of practice of individual physicians or comparing the practice of an individual physician with that of a group.

Decision Making

Measures of the value of a diagnostic test derived from stochastic thresholds.

Previous indices for measuring the potential impact of a diagnostic test on a physician's management of a given patient were derived based on a fixed threshold model. The authors adapted these indices to a stochastic threshold model. In the stochastic threshold model the physician's probability of treating the patient is a function of the patient's probability of disease. From this model the authors derived the management value index (the expected effect that the test has on the physician's probability for treating the patient) and the utility value index (the expected benefit to the patient if the diagnostic test is used). Graphs of the indices versus the patient's probability of disease may be useful in teaching appropriate use of diagnostic tests.

Diagnosis