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Biomedical subjects

R Caudarella

Publications and source records attributed to R Caudarella.

35 records · Page 2Linked to original sources
PubMed1977

[Electron microscopy features of renal changes in chronic lead poisoning (author's transl)].

The Authors report the results of a renal morphological study carried out on eight patients with chronic lead poisoning. The ultrastructural analysis showed changes, mainly involving the proximal tubules, as follows: 1) degenerative pattern (swollen mitochondria, dilated endoplasmic reticulum and scanty microvilli); 2) signs of metabolic hyperactivity (intranuclear granular inclusions, odd shaped nuclei); 3) regenerative pattern (poorly differentiated cells with few microvilli, shallow infoldings of basal cell membranes). In the glomeruli the most characteristic finding was a mesangial reaction. The basement membrane, in some cases, appeared to be thickened and the visceral epithelial cells hypertrophic. Interstitial fibrosis was present, as well as, occasionally, a certain degree of arteriolar hyperplasia. These data appear to confirm that chronic lead nephropathy has an extremely slow evolution.

Adult↗
PubMed1976

[Respiratory disease in foundry workers. An epidemiologic survey in three foundries (author's transl)].

The authors report the results of a survey performed in three cast iron foundries, with particular emphasis on the impairment of respiratory system in the involved workers. The results obtained showed a high prevalence of pneumoconiosis, which, as for roentgenologic and clinical features, appears to be different from usual silicotic pneumoconiosis. The highest prevalence of chronic bronchitis -- either associated or not with pneumoconiosis -- in the foundry workers examined is stressed, as well as the prevalence of squamous metaplasia of the bronchial epithelium. An important role in this aspect is supposed to be played not only by dusts, but even by tobacco smoke in favouring the onset of the above mentioned alterations is also confirmed.

Bronchitis↗
PubMed1975

[Histologic patterns of liver damage in chronic poisoning from tri-ortho-cresyl phosphate (author's transl)].

Six subjects, affected with TOCP polyneuritis, were submitted to liver biopsy by means of Menghini's technique. By means of both optic and electron microscopy, histologic and ultrastructural findings of liver damage were evaluated, whose genesis is believed to be due to the toxic effect of TOCP. The hepatocytes showed changes, mainly represented by cloud-vacuolar swelling of the cytoplasm, with abnormalities of nuclear membrane and lipofuscin pigment accumulation. The above mentioned patterns were found in all the examined needle biopsies, which possibly account for their toxic nature.

Cell Nucleus↗
PubMedDate not supplied

Osteoblast behaviour in the presence of bisphosphonates: ultrastructural and biochemical in vitro studies.

OBJECTIVE: A positive balance in bone remodelling is an important goal of bone metabolism both in the presence of the osteoporotic processes characteristic of ageing and, especially, of prosthetic implants. The aim of the present work was to obtain new information about the initial steps of osteoblastic growth in an in vitro osteoblastic model in the presence of two bisphosphonates. METHODS: Experiments were performed with Alendronate and Neridronate, two molecules used in the therapy of osteoporosis. Since differentiating features into osteoblastic cells are known to parallel the presence in the cytoplasm of alkaline phosphatase and osteocalcin, we also carried out immunohistochemical typing. RESULTS: Good differentiation and osteoblastic activity were generally observed in the cells in contact with these compounds, except for 10(-4) Neridronate, where biochemical data clearly indicated its toxic effect on the cells. CONCLUSION: The detection of osteoblastic markers associated with an ultrastructural picture of correct organellar morphology in our cultures further supports the hypothesis of a metabolically positive action of these molecules on osteoblasts.

Alendronate↗