Decrease of regulatory T cells in patients with systemic lupus erythematosus.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
R Castejon
Publications and source records attributed to R Castejon.
Electrophysiological and anatomical findings in heart transplantation: experimental study.
The diagnosis of acute rejection by electrophysiological methods is based on the fact that signs of rejection such as inflammatory infiltrate, interstitial edema, and mostly myocyte necrosis lead to obligated alterations in electrophysiological properties of the myocardium. In a total of 276 heterotopic abdominal transplants in rats, a noninvasive monitoring of heart allograft rejection by conventional ECG and electrophysiological techniques was performed. The correlation of these findings with pathological studies, including histologic determination of the degree of acute rejection, analysis of weight and cardiac perimeter, and volumetric cell density were also evaluated in 96 of them, 66 were allogeneic and 30 syngeneic. Sensitivity and specificity of the R wave and slew rate was also determined with respect to the Billingham classification. Results of the correlation analysis showed that electrophysiological variations in R wave and slew rate correlated more intensely with changes in volumetric cell density. The greatest sensitivity and specificity was observed in R wave changes in relation to the Billingham classification.
Abdomen↗
An experimental study of lymphatic vessel autotransplantation in the dog.
To provide greater insight into microsurgical treatment of lymphedema, 7 mongrel dogs underwent autotransplantation of a lymphatic collector into the contralateral lower limb. Two months later, lymphatic vessels were studied using patent blue dye, light microscopy, and histomorphometry. Patency of the transplanted lymphatics was uniformly observed although there was a notable increase in the width of the intima and a corresponding reduction in the size of the lymphatic lumen. Of note, there was a striking absence of inflammatory infiltrate at the recipient site.
Animals↗
Does a critical hemodynamic situation develop from right ventriculotomy and free wall infarct or from small changes in dysfunctional right ventricle afterload?
An experimental model for right ventricle free wall infarct associated with double ventriculotomy and tricuspid insufficiency was created to evaluate whether right ventricle failure can cause profound refractory heart failure or whether modifications in right ventricular afterload are more influential in this regard. In our model, the left ventricle, interventricular septum and right atrial wall were maintained intact and pulmonary banding made it possible to modify right ventricular afterload during the experiment. The results of our study showed that pure right ventricular failure does affect the hemodynamic state negatively, but it is not itself, a cause of death in dogs. A slight increase in the dysfunctional right ventricular afterload produced a profound deterioration in the hemodynamic state that required pulmonary artery debanding within no more than 10 minutes.
Animals↗
Electrophysiologic changes during acute rejection of heterotopically transplanted rat hearts.
Noninvasive monitoring of heart allograft rejection was performed by electrophysiologic techniques using an implanted electrode located on the epicardial surface of the heterotopic transplanted heart of rats. R wave and slew rate determinations were performed daily in 30 syngeneic and 66 allogeneic transplants. These determinations were later compared with histopathologic studies of the transplanted hearts. R wave and slew rate values of allogeneic or rejecting hearts were found to decrease significantly compared with syngeneic or nonrejecting hearts on the days studied. This noninvasive electrophysiologic method may be a promising method for monitoring heart allograft rejection.
Abdomen↗