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Biomedical subjects

R Carrillo

Publications and source records attributed to R Carrillo.

81 records · Page 5Linked to original sources
PubMedDate not supplied

[Surgery unit for epilepsy].

INTRODUCTION: Only few medically refractory epileptic patients are evaluated for surgical treatment, in spite of the good results obtained at the Centers where epilepsy surgery is performed. OBJECTIVE: We are presenting the way the Gregorio Marañón Hospital Epilepsy Surgery Unit functions and their casuistry. PATIENTS AND METHODS: This Unit is composed by members of the Services of Neurosurgery, Neurology, Neurophysiology, Neuroradiology, Psychology, Neuropediatry, Nuclear Medicine and Neuroanestesiology. Patients are studied by means of protocols. RESULTS: Twenty cases were operated upon. The procedures were temporal lobectomy in 9 cases, amygdalo-hipocampectomy in 4, frontal lobectomy in 3, frontal topectomy in 2, partial hemispherectomy in 1 and vagal nerve stimulation in 1. In 16 of the 19 surgery specimen there were some pathological abnormalities. In the short follow-up 13 patients are seizures free experience significant improvement.

Epilepsy↗
PubMedDate not supplied

[Early prognosis in chronic subdural hematomas. Multivariate analysis of 137 cases].

INTRODUCTION: In the literature there is evidence relating different factors such as age and preoperative clinical condition with prognosis in patients treated surgically for chronic subdural haematoma. OBJECTIVE: To clarify and quantify the magnitude of the factors which determine early prognosis (during hospital admission) of these patients. PATIENTS AND METHODS: We made a prospective study of 137 patients who had been operated on in our centre and found the relationship between different clinical and therapeutic variables with the clinical course and morbidity-mortality by means of multivariate and survival analysis. RESULTS: A high Markwalder functional score (3-4) is an independent factor of poor prognosis (OR = 13.15; CI 95% 6.1-28.4; p = 0.01), as is the presence of a coexisting coagulopathy (OR = 27.2; CI 95% 9.3-79.5; p = 0.01). Advanced age tended to increase the risk (OR = 1.104) but did not reach statistical significance (p = 0.0654). A multivariate logistic model, which included the functional score and presence of coagulopathy, correctly classified 94.7% of the cases studied. Analysis of survival showed two groups with different early mortality as a function of the Markwalder score (high: 3-4 and low: 0-1-2), which could be differentiated statistically (Log-Rank chi squared test: 3.95; p = 0.0468). CONCLUSIONS: The preoperative clinical state classified by functional scores and the presence of underlying coagulopathy are the main prognostic factors in chronic subdural haematoma during hospital admission. Advanced age is probably not in itself an independent factor for bad prognosis.

Aged↗
PubMedDate not supplied

[Cerebral cavernomas. A review and update of aetiological, clinical and therapeutic features].

INTRODUCTION: Cavernous angiomas are uncommon lesions, with a reported incidence of 0.4 to 0.8%, presenting a controversial management especially regarding their surgical treatment. AIM: To update cavernous angiomas characteristics and management through a deep review of the literature concerning their aetiology, epidemiology, history, signs and symptoms, diagnosis, and surgical and radiosurgical treatment. DEVELOPMENT AND CONCLUSIONS: Most important advances found in the recent literature include the identification of the genetic basis responsible for the familial form of cavernomatosis (CCM1, CCM2 and CCM3), the identification of the dynamic pattern of these lesions based on their pathology and imaging features, the deeper knowledge on their natural history depending on their supra/infratentorial location, and the main indications for surgical treatment and radiosurgical therapy suggested by the recent series.

Brain Neoplasms↗
PubMedDate not supplied

Ameloblastic fibroma. Report of a case with fine needle aspiration cytologic findings.

A case of ameloblastic fibroma of the jaw in an 18-year-old patient is presented. Fine needle aspiration cytologic smears showed two different types of cellular elements: a glandlike epithelial component, arranged in bidimensional, well-outlined clusters of basaloid cells with palisading of the columnar cells at the borders of those clusters, and a mesenchymal component that consisted of loosely arranged fusiform cells. These cytologic features appear to be sufficiently characteristic to suggest a diagnosis of ameloblastic fibroma by fine needle aspiration.

Adolescent↗
PubMedDate not supplied

Epithelial-myoepithelial carcinoma of the salivary gland. Fine needle aspiration cytologic findings.

A case of epithelial-myoepithelial carcinoma of the salivary gland in a 78-year-old patient is presented. Fine needle aspiration cytologic smears showed a moderate number of tumor cells arranged in three-dimensional, well-outlined clusters reminiscent of the ball-like structures of adenoid cystic carcinoma. The nuclei were small and monotonous, with finely granular chromatin and small nucleoli. A large number of cells showed abundant clear cytoplasm; however, in some of the clusters the cytoplasms were very scant, again mimicking adenoid cystic carcinoma. Fragments of pale homogeneous acellular material, isolated or surrounding the cellular clusters, were another conspicuous finding.

Aged↗
PubMedDate not supplied

Fine needle aspiration biopsy of myxoid metastasis of malignant melanoma.

The cytopathologic features of the fine needle aspiration biopsy of a myxoid metastasis of a cutaneous malignant melanoma are documented. The cytologic findings included fusiform-to-round cells with elongated cytoplasmic processes, fibroblastlike cells and inflammatory cells in a characteristic amorphous background substance. Immunocytochemical staining for S-100 protein was positive. The cytologic findings correlated well the histologic, histochemical, immunohistochemical and ultrastructural studies of the neoplasm. The cytologic differential diagnosis between metastases of malignant melanoma and other myxoid tumors of soft tissues is discussed.

Biopsy, Needle↗
PubMedDate not supplied

Interphase nucleolar organizer regions in the evaluation of serosal cavity effusions.

Argyrophilic nucleolar organizer regions (AgNORs) were determined in 38 pleural and peritoneal effusions from patients with malignant solid tumors. The results were correlated with the cytologic diagnosis and flow cytometric DNA analysis to determine the diagnostic potential of this technique. Cytologically, 13 effusions were benign, 23 malignant and 2 indeterminate (5.2%). The mean AgNOR counts for benign, malignant and indeterminate specimens were 2.99, 3.94 and 3.50, respectively. Low AgNOR counts (< 4.0) were obtained in 12 (90.9%) of the 13 benign, 16 (60.0%) of the 23 malignant and 1 of the indeterminate effusions. High AgNOR counts (> 4.0) were noted in 1 (9.1%) of the benign, 7 (35.0%) of the malignant and 1 (5.0%) of the indeterminate specimens. There was no statistically significant difference between the AgNOR count in benign and malignant effusions (P = .48). All 10 benign effusions analyzed with flow cytometry were DNA diploid. Seven (35.0%) of the 20 cytologically malignant effusions were DNA aneuploid, and 13 (70.0%) were DNA diploid. Proliferative activity was low (< 7.0%) in 23 cases and high (> 7.0%) in 7 (6 malignant and 1 benign). There was no statistical correlation between the AgNOR count and DNA ploidy (P = .11) or proliferative activity (P = .23). We conclude that the AgNOR method lacks sensitivity as a diagnostic tool for serosal cavity effusions.

Adenocarcinoma↗