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Biomedical subjects

R Caporale

Publications and source records attributed to R Caporale.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Ceftriaxone plus conventional or single-daily dose amikacin versus ceftazidime/amikacin as empiric therapy in febrile neutropenic patients.

Results of antibiotic treatment in 144 febrile episodes during drug-induced granulocytopenia are reported. 63 episodes were treated with ceftazidime plus amikacin and 81 with ceftriaxone (CFX) using single daily doses combined with amikacin either divided in three doses (CFX-1 group) or administered as single doses (CFX-2 group). The response rates were 51, 80, and 57% respectively. In this study CFX was more effective than ceftazidime and amikacin provided better results when administered using the standard 8-hour scheduling.

Adolescent↗
PubMedDate not supplied

Continuous-infusion cyclophosphamide plus vincristine, cytosine-arabinoside and prednisone for refractory acute lymphoblastic leukemia in adults.

BACKGROUND: Despite more aggressive salvage regimens, the prognosis of refractory acute lymphoblastic leukemia (ALL) is still poor. Hence, alternative approaches are warranted in heavily pretreated patients. Some studies suggest the enhancement of cyclophosphamide (CY) activity when given by continuous infusion. METHODS: To evaluate the effectiveness of this scheduling in refractory ALL, we treated 15 adult patients (4 primary resistant, 11 relapsed and refractory to salvage regimens) with a seven-day course of CY 350 mg/m2/day by continuous i.v. infusion, associated with vincristine, cytosine-arabinoside and prednisone. RESULTS: The median time for hematologic recovery was 18 days, with negligible extramedullary toxicity. Two patients died while aplastic, 3 were non responders, 10 (66%) achieved complete remission after the first cycle. The response duration ranged from 5 to 32 (median 14) weeks, and the median survival of responders was 23 weeks. It is noteworthy that half of the responding patients had been resistant to prior CY in different schedules and other drug combinations. CONCLUSIONS: These data seem to confirm that CY exerts its best antineoplastic activity by continuous infusion.

Adult↗