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Biomedical subjects

R Caplan

Publications and source records attributed to R Caplan.

82 records · Page 5Linked to original sources
PubMed1980

Platelet uptake of serotonin in psychotic children.

Platelet serotonin (5-HT) uptake was assayed in ten long-term hospitalized children subdivided into two diagnostic groups "autistic" and "other psychotic". Weekly blood samples were taken from these children over a period of 6-7 weeks and serotonin uptake was determined. Constant and significant uptake values (13.28 +/- 2.0 pmol serotonin/10(8) platelets/5 min for autistics and 9.59 +/- 1.58 pmol serotonin/10(8) platelets/5 min for other psychotics) were obtained. There was no correlation with drug treatment or with behavioral fluctuations in individual children. Three weekly uptake assays performed on six parents suggest the possible importance of genetic factors in these diseases. Biochemical-kinetic methodological problems of platelet 5-HT assessment are discussed.

Adolescent↗
PubMedDate not supplied

Preliminary study of frontal lobe 1H MR spectroscopy in childhood-onset schizophrenia.

Cerebral 1H MR spectra were recorded in 13 children and adolescents with schizophrenia and 12 healthy children and adolescents. Stimulated echo acquisition mode (STEAM) sequence was used to localize an 8-ml voxel bilaterally in the frontal gray matter. The frontal gray matter metabolite ratios for NAA/Cr, Ch/Cr, Glx/Cr, and mI/Cr in schizophrenic children and adolescents were 1.08 +/- .28, .64 +/- .23, 1.09 +/- .30, and .60 +/- .24, respectively. In comparison, these ratios were 1.59 +/- .35, .74 +/- .27, 1.23 +/- .36, and .58 +/- .29 in healthy children and adolescents. Decrease in the frontal lobe NAA/Cr of schizophrenic children and adolescents was statistically significant (P < .001). In contrast, the MR spectra localized bilaterally in the occipital gray matter (8 ml) showed no significant changes between the patients and the controls. In the occipital gray matter, the metabolite ratios were 1.21 +/- .26,.52 +/- .08, 1.00 +/- .11, and.55 +/- .12 inpatients versus 1.30 +/- .23, .45 +/- .10, 1.15 +/- .20, and .48 +/- .19 in controls. Our preliminary finding of reduced NAA/Cr ratio in the frontal gray matter is consistent with the neurodevelopmental models emphasizing dysfunction of frontal lobe areas in patients with schizophrenia.

Adolescent↗