Search PubMed⌕ Search

Biomedical subjects

R Capanna

Publications and source records attributed to R Capanna.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Osteoid osteoma of the femur with a double nidus: a case report.

Osteoid osteoma is a common benign lesion, that occurs in children and young adults. The authors report the observation of a multifocal lesion which is infrequently reported in the literature. S.A., a 10-year-old female came to our observation complaining of spontaneous pain in her right hip and cruralgia radiating to the homolateral knee over the last 6 months; the symptoms, which increased during the night, were relieved by treatment with NSAIDS. Clinical examination and imaging studies confirmed a diagnosis of osteoid osteoma with a double nidus; the lesion was treated by CT-guided thermo-ablation with radiofrequency under general anaesthesia. Complete regression of symptoms was observed at 2-year follow-up.

Catheter Ablation↗
PubMedDate not supplied

Tricalcium phosphate and hydroxyapatite ceramics in the surgery of bone tumors: preliminary results.

The authors report their preliminary experience in the use of substitutive bone compounds in order to fill the bone cavity after curettage. The material used is constituted by a biphasic compound, made up of tricalcium phosphate and hydroxyapatite. Twenty-one patients were submitted to surgery because of the presence of a benign or low-grade malignant tumor. After removing the neoplastic tissue the residual cavity was filled with: tricalcium phosphate/hydroxyapatite (5 cases); tricalcium phosphate/hydroxyapatite plus autogenous bone (8 cases); tricalcium phosphate/hydroxyapatite plus bone allografts (8 cases). A radiological evaluation obtained 12 months after treatment showed that the incorporation of the compound in granular form was nearly complete in most of the cases, while the blocks revealed partial remodelling which was more evident in the angles. Finally, bone resorption in the site of the compounds used was not observed.

Adolescent↗
PubMedDate not supplied

Neoadjuvant chemotherapy for the treatment of osteosarcoma of the limbs. Preliminary results in 100 patients treated preoperatively with high doses of methotrexate i.v. followed by cisplatin (i.a.) and adriamycin.

One-hundred patients affected with non-metastatic osteosarcoma of the limbs were treated according to a new adjuvant chemotherapy protocol. Preoperative treatment consisted in high doses of methotrexate (i.v.), followed after one week by cisplatin continuous intra-arterial infusion for 72 hours and adriamycin in intravenous infusion for 8 hours. There was good clinical and radiographic response in all of the cases, and conservative treatment was used in 86 cases (86%). A postsurgery histological examination of the segment showed "good" necrosis (greater than 90%) in 75 patients (75%). The incidence of "good" necroses obtained with this protocol was significantly higher as compared to that observed previously at our Center when a preoperative chemotherapy scheme was used, which involved methotrexate and cisplatin alone. Up until now, patients with a good histological response to preoperative chemotherapy have always had an excellent prognosis. Thus, it is our belief that the 23% increase in good histological responses observed must correspond to an increase in the percentage of healing. The preliminary results (83% of patients with no signs of disease) seem to encourage our hypothesis.

Adolescent↗
PubMedDate not supplied

[Magnetic resonance for the study of osteosarcoma].

The authors report their experience with MR imaging in the study of osteosarcoma. Two main elements were evaluated: signal characteristics and loco-regional staging. Seventy-one patients were studied: 65 of them had central long-bone osteosarcoma, and 6 had telangiectatic long-bone osteosarcoma. T1- and T2-weighted spin-echo sequences were employed and all cases were scanned on 3 planes (sagittal, coronal, and axial). In 28 patients MR imaging was performed both before and after preoperative chemotherapy. The obtained data were compared to surgical and pathological findings. With the exception of the typical signal patterns of quite-osteoblastic osteosarcoma (which presents with low signal on both T1- and T2-weighted sequences), no particular signal features were observed which could help distinguish the different types of osteosarcoma. MR imaging is the method of choice in loco-regional staging for, in our series, it allowed a rational and adequate surgical planning. For this purpose, at least a longitudinal T1- and an axial T2-weighted images are required.

Adolescent↗
PubMedDate not supplied

Total body bone scan in the evaluation of tumor response to preoperative chemotherapy in the treatment of osteosarcoma.

With the introduction of preoperative (neoadjuvant) chemotherapy in the treatment of osteosarcoma, an early preoperative evaluation of the effectiveness of chemotherapy is essential, so that treatment may be modified in cases which are not responsive, and so that the surgical margin may be planned. The authors evaluate the accuracy of total body bone scan with Tc99m MDP in determining response to chemotherapy in 43 patients affected with osteosarcoma of the limbs, and preoperatively submitted to two cycles of chemotherapy with MTX i.v. and CDP i.a. All of the cases were submitted to a double bone scan examination, before and after preoperative chemotherapy. A bone scan evaluation using a qualitative method was compared to the percentage of necrosis observed in the tumorous tissue by histological examination carried out after surgery. In 58% of the cases the two values corresponded perfectly, in 28% of the cases bone scan evaluation overestimated response, and in 14% it underestimated it. In order to obtain quantitative preoperative data on response to chemotherapy in osteosarcoma, orientation towards the use of more sophisticated bone scan methods seems to be necessary, with computerized analysis of captation by dynamic measurement after infusion of Tc99m MDP or by radiocompounds with intracellular fixation such as Ga 67.

Adolescent↗
PubMedDate not supplied

The use of xenograft in young patients treated with Pemberton-Zanoli osteotomy.

Records and x-ray films of a group of 150 patients submitted to 193 operations involving Pemberton-Zanoli acetabulum osteotomy were reviewed. Follow-up ranged from 5 to 131 months (mean 57 months). In all of the cases cortico-cancellous calf rib grafts were used. In consideration of the special kind of operation performed, the authors observed valuable results due to the good mechanical and biological features of the graft. The most important feature of the method was the immediate stability of the press-fit graft, allowing for prompt rehabilitation and function.

Acetabulum↗