Search PubMed⌕ Search

Biomedical subjects

R Candinas

Publications and source records attributed to R Candinas.

At least 73 records · Page 4Linked to original sources

[Cardiac arrhythmias--ECG and electrophysiologic assessment].

The 12-lead resting surface ECG plays a major role in the diagnosis of cardiac arrhythmias. As a screening method, it provides important information about the cardiac rhythm and possible underlying heart diseases. It enables interpretation of possible arrhythmia mechanisms, especially if the recording is obtained at the time of the rhythm disorder. Since rhythm disorders exhibit spontaneous variability, event recorders and Holter monitoring are very helpful complementary noninvasive tools in the diagnosis of cardiac arrhythmias. In addition, Holter ECG can be used in monitoring the response to antiarrhythmic agents and in risk stratification of arrhythmias in certain cardiac disease states. Physical exercise, by inducing physiological and pathophysiological changes, may provoke arrhythmias, which forms the basis of exercise-stress testing. Stress testing may also be indicated when antiarrhythmic agents are initiated or therapy altered. Electrophysiological Study (EPS) is a time-consuming and costly investigation, which in general is reserved for further evaluation of tachyarrhythmias, conduction disturbances and syncope of unknown origin and routinely performed prior to radiofrequency ablation. EPS should only be performed in tertiary-care centers by well-trained and experienced cardiac electrophysiologists.

Arrhythmias, Cardiac↗

[Current pacemaker treatment and technology].

The increasing use of microprocessor technology in pacemaker devices results, by multiple programmability, in a more reliable follow-up of pacemaker systems and accounts for individual patient program settings. Rate-adaptive and AV-sequential pacing allows physiologic pacing. The implantation of dual-chamber pacemakers is no longer precluded in patients with atrial tachyarrhythmias with the availability of pacemakers with automatic mode switching (DDD[R] to DDI[R]). The actual vast variability of pacemaker treatment modalities requires a careful evaluation of the indication for pacemaker implantation, with international guidelines being helpful in decision-making. Besides frequent pacemaker indications, the occasional patient with hypersensitive carotid sinus syndrome, neurocardiogenic syncope and hypertrophic cardiomyopathy may benefit from pacemaker treatment. Temporary pacemaker functions with programmable stimulation extend the diagnostic and therapeutic horizon of various arrhythmia treatments.

Adult↗

Are there stereoselective electrophysiologic effects of intravenously administered (S)- or (R)-propafenone hydrochloride in patients with supraventricular tachycardia?

OBJECTIVE: The electrophysiological effects of intravenously administered pure (S)- and (R)-propafenone hydrochloride has been determined for the first time in humans-12 patients with supraventricular tachycardia. METHODS: Measurements were performed before and during drug therapy. RESULTS: (S)- and (R)-propafenone prolonged the AH interval from 82 to 107 ms and 75 to 84 ms, respectively, and significantly increased the V nodal Wenckebach cycle length by 58 ms and 37 ms, respectively. The AV nodal effective refractory period in both groups was increased significantly to the same extent (45 vs 42 ms). Sinus node recovery times were not significantly influenced by either enantiomers. Both (S)- and (R)-propafenone significantly prolonged the HV interval to the same extent (from 41 to 51 ms, and 42 to 53 ms). Changes in the electrophysiological characteristics of the myocardium were more pronounced in the atria than in the ventricles. Only (S)-propafenone significantly increased the atrial effective refractory period from 204 to 230 ms, and the ventricular effective refractory period from 225 to 241 ms compared to (R)-propafenone (from 221 to 239 ms, and from 219 to 222 ms, respectively). There was a more pronounced electrophysiological effect on AV nodal conduction of (S)- than (R)-propafenone, probably as a result of its beta-blocking activity. CONCLUSION: The electrophysiological effects of (S)-compared to (R)-propafenone were not very pronounced, so it still remains questionable whether one of the enantiomers might be clinically superior to the other, or to the racemic mixture.

Adult↗

Interaction between amiodarone and lidocaine.

We investigated the in vitro and in vivo interaction between amiodarone and lidocaine. The interaction on a molecular level was first studied in microsomes from 11 human livers. Close correlations between amiodarone N-monodesethylase activities and (a) the amounts of cytochrome P-4503A4 (CYP3A4), and (b) the rates of lidocaine N-monodesethylation were observed. Lidocaine inhibited amiodarone N-monodesethylation (Ki = 120 microM) competitively; inversely, amiodarone suppressed lidocaine N-monodesethylase activity in the same manner (Ki = 47 microM). Moreover, the metabolite N-monodesethylamiodarone (DEA) was stable and inhibited lidocaine metabolism in a concentration-dependent manner. The in vivo interaction was investigated in 6 cardiac patients. Each of them received a dose of 1 mg/kg lidocaine hydrochloride intravenously (i.v.) on three different occasions: before amiodarone treatment (control), and after cumulative doses of 3 g (phase I) and 13 g (phase II), respectively, amiodarone hydrochloride. The analysis of lidocaine pharmacokinetics showed an increase in lidocaine area under the curve (AUC) when amiodarone was administered, whereas that of N-monodesethylated lidocaine decreased. Moreover, the systemic clearance of lidocaine decreased, while the elimination half-life (t1/2) and the distribution volume at steady state of lidocaine remained unchanged. The pharmacokinetic parameters during phase II were the same as those during phase 1, indicating that the interaction had already occurred early in the loading phase of amiodarone administration. The interaction between amiodarone and lidocaine may be explained by the inhibition of CYP3A4 by amiodarone and/or by its main metabolite DEA.

Adult↗

[Analysis of early and late results of surgically treated Wolff-Parkinson-White syndrome].

The results of surgical procedures for termination of Wolff-Parkinson-White (WPW) Syndrom were assessed in 59 patients undergoing operation between January, 1980 and December, 1993. All cases of WPW were refractory to medical treatment and 14 of 58 patients had one or several syncopes, and 4 of them had to be reanimated. The surgical treatment of these patients was a dissection of an accessory atrioventricular pathway. 15 patients required additional heart operation. A total of 60 accessory pathways were diagnosed preoperatively, 64 were located intraoperatively. The reoperation rate was 3% (2 patients) due to persistent WPW. Incidence of total AV block after the operation was 7% (4 patients). In the late postoperative stage, 12 patients developed supraventricular tachycardias, but none of these cases required a surgical treatment. The actuarial survival rate after 10 years was 100% and after 14 years 96%. We conclude that surgical dissection of accessory pathways offers a good alternative in cases of unsuccessful catheter ablative procedure or in cases of additional heart operation.

Adolescent↗

[Initial clinical results with a novel implantable cardioverter-defibrillator: a prospective evaluation in 3 Swiss university hospitals].

The most important technical improvements of implantable cardioverter-defibrillators (ICD) of the latest generation comprise more sophisticated antitachycardia pacing options, stored intracardiac electrograms and biphasic shock capabilities which virtually always allow ICD implantation without thoracotomy. The present study summarizes the first clinical experience with these new devices. In 37 consecutive symptomatic (near sudden death 17, syncope 16, pre-syncope 4) patients aged 56 +/- 10 years with refractory ventricular arrhythmias (presenting arrhythmia: ventricular fibrillation 14, ventricular tachycardia 22, not documented 1), an ICD (Jewel PCD 7219, Medtronic) was implanted. Coronary artery disease was present in 21, dilated cardiomyopathy in 5, valvular heart disease in 2 and various conditions in 8 patients; the mean left ventricular ejection fraction was 43 +/- 18%. In 29 patients (78%), the ICD was inserted in a pectoral and in 8 (22%) in an abdominal position. A non-thoracotomy lead (NTL) configuration was successfully implanted in 36/37 patients (97%) (purely transvenous systems in 30, in combination with subcutaneous patch electrode in 6). Surgical complications comprised one pneumothorax, one hemorrhage and one death due to sepsis; during a mean follow-up of 5 +/- 3 months, another patient died of heart failure and 2 revisions (5.4%) for lead problems (1 connector, 1 SQ-patch) became necessary. In 23/37 patients (62%), the ICD was activated after 74 +/- 89 days post implant. 22 of these 23 patients (96%) received one or more appropriate shocks (9 +/- 22 shocks per patient). The actuarial survival was 95% at 6 months. In the present study, an ICD of the newest generation was successfully implanted without thoracotomy in > or = 97% and with purely transvenous systems in > or = 84%. Compared to older systems, this has made the implantation procedure remarkably easier and will most likely lead to a further reduction in mortality and morbidity. Despite the relatively short follow-up, the high incidence of appropriate ICD utilization underscores the high recurrence rate of arrhythmias in this population and suggests that the ICD may be very effective in preventing unnecessary rehospitalizations.

Aged↗

[The maze operation: surgical therapy of chronic atrial fibrillation].

The maze operation is a newly developed surgical procedure for patients with chronic atrial fibrillation. Between may 1993 and october 1994, 11 patients underwent mitral valve surgery combined with the maze procedure, 10 for chronic, medically refractory, symptomatic atrial fibrillation and 1 for intermittent, symptomatic atrial flutter. In one patient, a double aorto-coronary venous bypass was added. The operative mortality was 9%: one patient died on the 7th postoperative day from a perioperative cerebrovascular accident. Postoperatively, electrophysiological and stress testing as well as transthoracic or transesophageal echocardiography (TTE; TEE) were performed. All patients were in sinus rhythm. Left and right atrial contractions were analyzed by TTE/TEE and the atrial transport function was documented in each patient. The postoperative exercise stress test revealed slight sinus-node incompetence. After a mean follow-up time of 10.4 +/- 5.4 months (1 to 16 months) all surviving patients are free from atrial fibrillation or flutter and without need for medication. The maze operation, which we performed for the first time in connection with mitral valve surgery, is a successful treatment for chronic, medically refractory atrial fibrillation and intermittent, symptomatic atrial flutter. This procedure provides a sinus rhythm with atrioventricular synchrony, restores the atrial transport function and obviates the need for antiarrhythmic drugs. Long-term anticoagulation appears unnecessary.

Adult↗

[Retrospective analysis of early and late results following surgical intervention in supraventricular arrhythmia].

The results of surgical procedures for treatment of supraventricular tachycardias were assessed in 65 patients undergoing operation between January, 1980 and December, 1993. Indications for intervention were WPW (59 patients), atrial fibrillation (5 patients) and atrial flutter (1 patient). All cases of WPW were refractory to medical treatment and 14 of 58 patients had one or several syncopes, 4 of whom had to be resuscitated. The surgical treatment of these patients was dissection of an accessory atrioventricular pathway. 15 of these patients underwent heart operation for a different indication at the same time. A total of 60 accessory pathways were diagnosed preoperatively, while 4 were located intraoperatively. The reoperation rate was 3% (2 patients) due to persistent WPW. Incidence of total AV block after the operation was 7% (4 patients). In the late postoperative stage, 12 patients developed supraventricular tachycardias, but none of these cases required surgical treatment. The actuarial survival rate after 10 years was 100%, and after 14 years 96%. We conclude that surgical dissection of accessory pathways offers a good alternative in cases of unsuccessful catheter ablative procedures or in cases of concomitant heart surgery. In 6 patients with mitral valve surgery, associated chronic atrial fibrillation was found. A concomitant Maze-procedure was performed for the purpose of surgically converting the atrial fibrillation to a stable sinus rhythm. The early postoperative results are promising.

Adolescent↗

Influence of exercise induced myocardial ischemia on right ventricular dP/dt: potential implications for rate responsive pacing.

BACKGROUND: Right ventricular (RV) dP/dtmax has been used as a simple parameter for rate responsive pacing to simulate the normal sinus node function. However, the effect of acute myocardial ischemia on RV dP/dtmax has not yet been evaluated. METHODS: RV high fidelity pressure was measured in 21 patients at rest and during supine bicycle exercise. Nine patients (Group 1 = controls) had no or only minimal alterations of the coronary arteries and 12 (Group 2 = CAD) had significant coronary artery disease with exercise induced left ventricular (LV) wall-motion abnormalities (n = 10) and/or angina pectoris (n = 6). RV pressure and its first derivative (RV dP/dt) were determined by an 8 French micromanometer catheter. The time constant of RV pressure decay (Tau) was calculated from the negative reciprocal of RV pressure versus negative dP/dt during isovolumic relaxation. RV volumes and ejection fraction were calculated from RV biplane angiograms (multiple slice method) at rest and during exercise. RESULTS: Heart rate (HR), RV dP/dtmax and dP/dtmin increased significantly during exercise, whereas Tau decreased. There were no significant differences between the two groups, although RV ejection fraction increased from 67% to 72% in the control group but decreased from 63% to 51% in the CAD group (P < 0.05). An exponential relationship was found between HR and dP/dtmax with a correlation coefficient of 0.82 (P < 0.01; SEE = 7% of the mean value). CONCLUSIONS: Acute exercise induced myocardial ischemia does not significantly influence RV dP/dtmax during sinus rhythm. Consequently, this index of RV contractility may be used in patients with coronary artery disease as a simple parameter for rate responsive pacing.

Adult↗

[Anti-arrhythmia agents in the therapy of ventricular arrhythmias in the post-CAST era].

This review provides a 20-year perspective on the most significant reports on antiarrhythmic drug therapy of ventricular arrhythmias, with particular reference to the CAST trials. The following conclusions are drawn: 1. Based on the CAST trials and other studies investigating the effectiveness of antiarrhythmic agents during the last 20 years, prophylactic treatment with antiarrhythmic class I, III and IV drugs after myocardial infarctions is not indicated. 2. Betablockers without intrinsic sympathomimetic activity are effective in the prevention of reinfarction and sudden cardiac death. 3. The effectiveness of amiodarone as secondary prophylaxis is currently under investigation in several multicenter trials. 4. Antiarrhythmic intervention is indicated in patients with hemodynamically compromising ventricular tachycardia or ventricular fibrillation, irrespective of spontaneous ventricular arrhythmias. Effective treatment with arrhythmic agents can be achieved in approximately half of the patients. Arrhythmia surgery, implantable cardioverters/defibrillators, or heart transplantation are possible alternative treatment modalities.

Adrenergic beta-Antagonists↗

[Differential diagnosis of acute consciousness disorders].

The most important causes of syncope and coma are discussed. Syncope may be due to cardiac, vascular or cerebral disease. A cause of syncope is not established in up to 50% of cases. Where a diagnosis is possible the patient's history, physical examination, ECG and prolonged ECG monitoring serve to establish the underlying disease in most cases. Additional diagnostic tests should only be performed in patients with possible cardiac syncope, since these cases show a higher mortality rate than patients with non-cardiac syncope. Coma may be caused by metabolic disorders, intoxication or cerebral diseases, which are easily identified by history, physical examination and simple laboratory tests in most cases. Further evaluation of patients with unknown cause of coma depends on whether focal neurologic signs, meningeal irritation and fever are present.

Acute Disease↗

[Cardiac syncope: 4 case reports].

We describe 4 patients with syncopes due to tachycardias of different etiologies. The causes and prognostic importance of syncopes are discussed together with the therapeutic options, e.g., antiarrhythmic therapy guided by programmed ventricular stimulation, surgery for ventricular tachycardia, implantation of a cardioverter/defibrillator, and radiofrequency ablation of arrhythmias. In particular, the clinical presentation of arrhythmogenic right ventricular dysplasia and Wolff-Parkinson-White syndrome are outlined.

Adult↗

Risk factors for systolic dysfunction and ventricular dilatation in hypertrophic cardiomyopathy.

The history of an 18-year-old male with hypertrophic cardiomyopathy (HCM) and ventricular dilatation is presented and the literature on systolic dysfunction and ventricular dilatation in patients with HCM is statistically analyzed in search of risk factors. The patient was followed for 7 years when he developed recurrent ventricular fibrillation, left ventricular dilatation and low cardiac output. An automatic cardioverter-defibrillator was implanted but the patient died of electro-mechanical dissociation. In order to define risk factors for systolic dysfunction and ventricular dilatation in HCM, the literature data of 17 patients with this complication were compared to a group of 139 consecutive patients with HCM from our hospital. The risk factors identified were a more markedly increased septal (20.1 vs. 18.0 mm, P < 0.05) and posterior wall thickness (13.6 vs. 11.0 mm, P < 0.001) in the patients subsequently developing systolic dysfunction and ventricular dilatation, whereas age, sex and the ratio between septal and posterior wall thickness were not significantly different between the two groups. A severely increased ventricular mass appears to be a risk factor for the development of systolic dysfunction with ventricular dilatation in HCM. Prognosis is usually poor and the reported case showed fatal ventricular arrhythmia despite the implantation of an automatic cardioverter-defibrillator.

Adolescent↗

Adenosine-induced non-sustained polymorphic ventricular tachycardia.

Adenosine has become widely used because of its diagnostic and therapeutic value in the emergency management of arrhythmias. It produces transient heart block by slowing conduction through the AV node and thus terminates supraventricular tachycardias that involve the atrioventricular node. Bradyarrhythmias of short duration are common side effects of the use of this drug. Premature atrial and ventricular beats have also been reported. The very short half-life and lack of serious adverse effects generally lead to the consideration that adenosine is a safe drug. We describe a 56-year-old woman with a supraventricular tachycardia. To terminate this rhythm disorder intravenous adenosine was given. Interruption of the supraventricular tachycardia was followed by non-sustained polymorphic ventricular tachycardia.

Adenosine↗

Comparison of spectral temporal mapping to the time domain signal-averaged electrocardiogram in normal subjects and in patients with coronary artery disease and sustained ventricular tachycardia.

Spectral temporal mapping is a new form of analysis for signal-averaged electrocardiography, which has the goal of improving the sensitivity and specificity of traditional time domain analysis. Our objective in this study was to determine the effectiveness of one form of spectral temporal mapping, in the face of conflicting results that have so far been reported with this approach. We prospectively performed both spectral temporal mapping and time domain analysis on 50 patients with a history of coronary artery disease and inducible sustained monomorphic ventricular tachycardia (Group 1) and on 25 normal subjects with normal electrocardiograms and no history of heart disease (Group 2). We found that for the 40 Group 1 patients without bundle branch block (Group 1A), the sensitivity of spectral temporal mapping was lower than that for time domain analysis (45% vs 80%, P < 0.005). The results of spectral temporal mapping for Group 1A patients were similar to that for all of Group 1. The sensitivity of spectral temporal mapping was 60% (n = 10) for patients with bundle branch block (Group 1B). The specificity noted in Group 2 was 88% by each means of analysis; however, no one in Group 2 had an abnormal finding by time domain and spectral temporal mapping. Attempts to optimize the criteria for an abnormal spectral analysis did not identify criteria that were superior to those currently in use. We conclude that spectral temporal mapping using Haberl's method is inferior to time domain analysis in identifying patients with sustained ventricular tachycardia, but may be of value in conjunction with the traditional approach in identifying normal subjects.

Action Potentials↗

Plasma triglycerides and three lipoprotein cholesterol fractions are independent predictors of the extent of coronary atherosclerosis.

BACKGROUND: The lipoprotein system has manifold links to atherosclerotic disease. LDL cholesterol is related to lesion formation and growth. The cholesterol of HDLs is indicative of protection against atherosclerosis. The status of triglycerides and of subfractions of high-density lipoproteins as risk factors is less certain. Also, the magnitude of the atherogenic/protective power of these factors is not known. METHODS AND RESULTS: Five hundred patients (418 men and 82 women) were enrolled in an angiographic study. A total of 1006 coronary lesions with > or = 50% narrowing were recorded as study end points. By extent of atherosclerosis, defined as the number of > or = 50% lesions, the study subjects were allocated to one of four ordered categories with 0, 1 to 3, 4 to 6, or 7 to 10 lesions, respectively. Subfractions of HDL cholesterol were determined by a dual precipitation method. By a polychotomous logistic regression model, it was found that, besides age and sex, LDL cholesterol, HDL2 cholesterol, HDL3 cholesterol, and triglycerides were independently predictive (P < .05) of the extent of coronary atherosclerosis. An increase in age by 10 years was associated with an increase of the odds ratio for falling into a higher-extent category by a factor of 1.64, and the same increase of the odds ratio was obtained by increasing LDL cholesterol by 0.92 mmol/L or triglycerides by 1.01 mmol/L and by decreasing HDL2 cholesterol by 0.20 mmol/L or HDL3 cholesterol by 0.46 mmol/L. The less sensitive coronary end point, presence of atherosclerosis (ie, observation of > or = 1 lesion of > or = 50%) depended significantly on age, sex, LDL cholesterol, and HDL2 cholesterol, but not on HDL3 cholesterol or triglycerides. CONCLUSIONS: In addition to LDL, HDL2, and HDL3 cholesterol, triglycerides also proved independently predictive of the extent of coronary atherosclerosis.

Cholesterol, HDL↗