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R Campos

Publications and source records attributed to R Campos.

At least 127 records · Page 7Linked to original sources
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The contribution of epidemiology to psychosomatic medicine.

OBJECTIVE: To discuss the contribution of epidemiology and epidemiological methods to psychosomatic medicine. METHOD: Critical review of the literature, including both philosophical concepts and empirical data. RESULTS: The adjective "psychosomatic" has been used in two different ways: in the so called "psychosomatic" or holistic approach to medicine; and in a narrower approach, referring to particular disorders in which psychological factors were considered to have a fundamental aetiological role. While the ideal of the holistic, "humanistic" or "anthropological" approach should probably be never abandoned, the practical limitations of encompassing models, including Engel's bio-psycho-social model are also obvious: they may be heuristically sterile. On the other side, in relation to the narrow psychosomatic approach, psychogenetic views in the so called "psychosomatic illnesses" have been strongly criticized on empirical grounds. The potential of epidemiological methods to study these illnesses, but also "somatopsychic" disorders is shown in a number of papers in the empirical literature. We have grouped such contributions, including our own experience, in the five categories suggested by M. Shephered for epidemiological methods in general: 1) the completion of the spectrum of disease; 2) the establishment of outcome; 3) the actuarial assessment of morbid risk; 4) the evaluation of the efficacy of treatment; and 5) the conceptual construction of diagnosis and classification. CONCLUSIONS: The contribution of epidemiological data to areas of interest in psychosomatic medicine has been relevant in recent years. The potential of epidemiological methods in this area is very important both to increase knowledge and to improve the quality of clinical practice.

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[Treatment of experimental infection by Strongyloides venezuelensis in rats, with the use of injectable ivermectin and levamisole].

For the therapy of human strongyloidiasis, are necessary effective drugs to eliminate both larvae and adult worm parasitism, which may also be used by parenteral route, to obviate the particular conditions presented by many patients. A study based on the experimental infection by Strongyloides venezuelensis in rats was done, administering injectable ivermectin or levamisole. Both drugs were shown to be active, when used in single doses of 0.2 to 0.5 mg/kg of ivermectin, or 26 mg/kg for levamisole. Ivermectin was slightly more effective as far as larval stage of the infection is concerned, and the same happened for levamisole for the adult worm stage. Promising perspectives are visualized to improve the therapy of patients with serious disseminated infection by Strongyloides stercoralis.

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[Eventual effect of artemisinine on the experimental infection of mice by Toxoplasma gondii].

Because of taxonomic similarities to previous data found in the literature, and with the aim of improving treatment of toxoplasmosis, we considered it of interest to assay artemisinin, an effective anti-malarial agent, for the treatment of experimental infection in mice by Toxoplasma gondii. Different amounts of the anti-parasitic agent were administered, including after previous contact in vitro with toxoplasma and stimulated macrophage production. With the methodology used artemisinin was not effective. Suggestions for further studies are made.

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[Xenodiagnosis in Chagas disease: influence of the triatominae sex].

We evaluated, comparatively, the performance of female and male Triatoma infestans in the 5th instar of development, in xenodiagnosis for Chagas' disease. Xenodiagnosis were done in 40 patients with chronic infectans. For each diagnosis 20 nymphs female and 20 nymphs males were used, which were weighed immediately before and after the meal. Intestinal contents were examined about 20, 30, 60 and 90 days after the xenodiagnosis application. The females and males ingested the mean of 230 and 210 mg of blood, respectively. The results revealed positivity of 15 (37.5%) out of 40 xenodiagnosis, but any of the positive tests show 100% of the nymphs, female and/or male infected by T. cruzi. The females ingested significantly more blood than the males; this is coincidental with the higher female positivation to T. cruzi here observed. Our results suggest that the female nymphs seem able to increase the sensibility of the xenodiagnosis for chronic patients with Chagas' disease being necessary further studies are necessary to confirm this hypothesis.

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