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Biomedical subjects

R Callivà

Publications and source records attributed to R Callivà.

5 recordsLinked to original sources
PubMed2000

The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery.

BACKGROUND: The purpose of this study was to evaluate the clinical usefulness of the lidocaine test, as an index of hepatic function, in the different fields of liver surgery. METHODS: The lidocaine (MEGX [monoethylglycinexylidide]) test, which was performed in 200 patients with different liver diseases and in 23 organ donors, was compared with common laboratory tests. The MEGX value was related to postoperative complications in patients who undergo liver resection and to the survival of patients with cirrhosis who are awaiting transplantation. In organ donors, the test was related to the outcome of patients who underwent transplantation. RESULTS: The MEGX value was significantly higher in patients without cirrhosis compared to patients with cirrhosis (77.8 +/- 25 ng/mL vs 35.6 +/- 30 ng/mL; P < .05); among patients with cirrhosis, there was a significant difference between those patients classified Child A and those classified Child B and C (43.3 +/- 25 ng/mL vs 11.5 +/- 7.1 ng/mL; P < .05). The patients classified Child A who underwent liver resection with MEGX value less than 25 ng/mL had a significantly higher rate of postoperative complications compared with other patients (P < .001). Patients with cirrhosis who were awaiting liver transplantation and who had a MEGX value of less than 10 ng/mL had a life expectancy of no longer than 1 year. CONCLUSIONS: The MEGX test is a reliable index of hepatic function. Patients carrying hepatocellular carcinoma with MEGX value of less than 25 ng/mL have a high risk of liver insufficiency after hepatic resection. Patients with decompensated cirrhosis who have an MEGX value of less than 10 ng/mL should undergo transplantation as soon as possible.

Adult↗
PubMed1991

Flecainide: evidence of non-linear kinetics.

The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.

Adult↗
PubMedDate not supplied

[Lysine acetyl salicylate. Clinical contribution and preliminary data].

In the general study of antipyretic products for children prone to febrile convulsions, the authors describe the results obtained administering, the rectal route, three different doses of lysine acetylsalicylate (20-30-40 mg/kg/b.w.) to 53 children with fever. The lower dose was often inadequate in these patients, who need a quick reduction of body temperature below 38 degrees C. The two higher doses were useful both in clinical and in statistical terms, without relevant differences between groups. A statistically significant inverse correlation between blood levels of salicylates and temperature was also shown. No undesirable side effects were observed. The authors conclude that ASL, by rectal route, has to be considered a drug of choice for this indication.

Administration, Rectal↗