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Biomedical subjects

R C Wilson

Publications and source records attributed to R C Wilson.

At least 127 records · Page 7Linked to original sources
PubMed1984

Hepatic metabolite concentration in lactic acidotic sheep.

The concentration of hepatic metabolites associated with energy-producing pathways and hepatic oxygen consumption were measured in clinically normal and lactic acidotic sheep. Significantly (P less than 0.005) lower pyruvate concentrations in livers of acidotic sheep produced significantly larger L-lactate to pyruvate concentration ratios. Glycogen concentrations were significantly (P less than 0.005) lower in liver from acidotic sheep. Oxygen consumption by liver from acidotic sheep was depressed when compared with oxygen consumption by normal sheep liver. Seemingly, limited available carbohydrate substrate and not tissue oxygenation may be limiting aerobic glycolysis in liver of lactic acidotic sheep.

Acidosis↗
PubMed1983

Gentamicin pharmacokinetics in horses given small doses of Escherichia coli endotoxin.

The pharmacokinetics of gentamicin (3 mg/kg of body weight) were evaluated in 6 healthy horses and in 6 horses after they were given Escherichia coli endotoxin (0.113 microgram/kg). In the horses given endotoxin, there were a maximum temperature increase of 1.97 +/- 0.44 degrees (C) and a fever index (between the 2 groups) of 8.754 units. Other mild signs of endotoxemia also occurred. Statistically significant changes were not observed in the rate constants for distribution (alpha) or elimination (beta) or in body clearance (ClB) of gentamicin in the 2 groups of horses. In the horses given endotoxin, significant (P less than 0.05) increases were found in the serum concentration data (A, B, and CoS), and significant decreases were found in the apparent volume of distribution [Vd(area)] and in the volume of the central compartment (Vc). The alterations in gentamicin kinetics in the horses given endotoxin are believed to result from the decrease in Vc. This indicates that the extracellular fluid volume available for gentamicin distribution may be reduced by endotoxin.

Animals↗
PubMed1983

Esophageal hemangioma: diagnosis with computed tomography and radionuclide angiography.

Esophageal hemangioma is a benign tumor that may cause dysphagia and upper gastrointestinal bleeding. Invasive measures such as endoscopic biopsy and surgical excision have been required for diagnosis in most reported cases. We have reported a case focusing on the use of two noninvasive techniques, contrast CT and radionuclide angiography, in the diagnosis of esophageal hemangioma.

Aged↗
PubMed1982

Acute effects of N-methyl-DL-aspartate on the release of pituitary gonadotropins and prolactin in the adult female rhesus monkey.

The acute effects of an aspartic acid analogue, N-methyl-DL-aspartate (NMA), upon the release of several anterior pituitary hormones were examined in adult female rhesus monkeys. Intravenous injection of NMA (15 mg kg body weight) induced a large and rapid rise in plasma levels of luteinizing hormone, follicle stimulating hormone, and prolactin. Thyroid stimulating hormone concentrations were not altered. Thus, in primates, as in rodents, systemically administered NMA is capable of eliciting pituitary hormone secretion, although the site of its action in the rhesus monkey remains to be established.

Animals↗
PubMed1982

Effects of promethazine on hemorrhagic shock in the dog.

The effects of pre- and post-treatment with promethazine, an antihistamine, in hemorrhage-shocked dogs were investigated. Survival to 6 hours was enhanced in the dogs given (IM administration) the H1-receptor antagonist at 1 hour before hemorrhage was induced when compared with survivals of saline-treated control dogs (3 of 5 dogs vs 1 of 5 dogs). Furthermore, 4 of 5 dogs given (IV administration) promethazine at 30 minutes after the initial hemorrhage survived. Promethazine treatment by either route increased mean arterial pressure among surviving dogs throughout the 6-hour experimental period.

Animals↗
PubMed1981

Determination of blood pressure by indirect methods in dogs given acetylpromazine maleate.

This study was designed to monitor and compare indirect blood pressures by two methods (ultrasonic Doppler and photoelectric) after intravenous acetylpromazine maleate at three different doses (0.11, 0.55, and 1.10 mg/kg). Sixteen unanesthetized dogs were placed in right lateral recumbency and pressures estimated from the left hind leg at two preinjection times and at 3, 15, 60 and 120 minutes postinjection. This procedure was followed for each dog for each of the three doses. Preinjection ultrasonic mean values and standard deviations were similar to published values. Photoelectric systolic pressures were lower and diastolic pressures higher than ultrasonic systolic and diastolic pressures. The decrease in blood pressure was detected by both methods. Neither method revealed a dose related response.

Acepromazine↗
PubMed1981

Effect of hypocalcemia on motility of the ruminant stomach.

The sensitivity of ruminal and abomasal contractions to hypocalcemia was evaluated in sheep. Serum diffusible calcium concentrations were determined during induction of hypocalcemia (IV infusion of Na2EDTA) and recovery from hypocalcemia (no infusion). Contractile strength of the rumen gradually decreased as serum diffusible calcium concentrations decreased; significant correlation (r = 0.75; P less than 0.001) was observed. Ruminal contractions disappeared before clinical signs of hypocalcemia were seen. Abomasal contractions were slightly reduced when serum diffusible calcium concentrations were equal to those producing ruminal stasis and clinical signs of hypocalcemia. These observations indicated that ruminal dysfunction may occur considerably before the onset of clinical signs of hypocalcemia.

Abomasum↗