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Biomedical subjects

R C Watzke

Publications and source records attributed to R C Watzke.

At least 37 records · Page 2Linked to original sources
PubMed1983

Diabetic rubeosis and panretinal photocoagulation.

Iris fluorescein angiography was used to perform the first prospective, controlled, masked evaluation of the effect of panretinal photocoagulation on diabetic rubeosis. Eyes with rubeosis had iris fluorescein angiograms five to seven weeks apart. Eyes either had laser treatment immediately after the first angiogram or had no laser treatment between angiograms. The rubeosis was said to have improved if all three masked readers independently selected the angiogram performed last as having the less severe rubeosis. In eyes with severe rubeosis, only two of 11 (18%) spontaneously improved whereas 11 of 15 (73%) improved following laser therapy. In eyes with mild rubeosis, one of ten improved spontaneously and one of ten improved following laser therapy. Iris fluorescein angiography documented regression of severe but not mild rubeosis following panretinal photocoagulation.

Clinical Trials as Topic↗
PubMed1983

Syphilitic neuroretinitis.

Four patients (three men, 32, 43, and 53 years old, and one 37-year-old woman) with syphilitic neuroretinitis had cerebrospinal fluid evidence of neurosyphilis. Therapy failed in one patient given penicillin G benzathine intramuscularly and it may have failed in a second patient. Another treatment failure occurred in a patient given tetracycline orally. Intramuscular penicillin G benzathine or intramuscular penicillin G procaine in doses of less than 2.4 million units/day does not produce spirocheticidal drug levels in the cerebrospinal fluid. All four patients improved after high-dose treatment with aqueous penicillin G.

Administration, Oral↗
PubMed1982

Histopathology of Best's macular dystrophy.

The pathogenesis of Best's macular dystrophy (BMD) is poorly understood. Previous histopathologic descriptions of BMD have been published in the literature; however, all were from elderly persons who clinically exhibited late manifestations of the disease. In this article, light and electron microscopic observations of an earlier stage of BMD are reported. Both globes were from a 28-year-old patient who had a "scrambled egg" lesions in the macula with some features of a pseudohypopyon. Our studies indicate that BMD is a generalized retinal pigment epithelial (RPE) abnormality that results in an abnormal accumulation of lipofuscin granules. Lipopigment accumulates within the RPE, within macrophages in the subretinal space, and within the choroid. These observations help to explain the clinical appearance as well as the fluorescein angiographic and electrophysiologic findings of this conditions.

Adolescent↗
PubMed1982

Pattern dystrophy of the retinal pigment epithelium.

The pattern dystrophies are a group of hereditary macular dystrophies characterized by lesions of the retinal pigment epithelium (RPE) arranged in various patterns of dots, lines, and branched figures. This report of two pedigrees expands the clinical spectrum. The onset is usually in the second and third decade, there is great variation in fundus appearance, vision may be severely affected, the EOG is not always abnormal, and the fundus lesions change with time. The lesions resemble those of Best's vitelliform degeneration and fundus flavimaculatus, and, possibly, also represent abnormal lipofuscin accumulation within degenerating retinal pigment epithelial cells.

Adolescent↗
PubMed1981

The long-term course of multifocal choroiditis (presumed ocular histoplasmosis).

We studied 40 patients with the presumed ocular histoplasmosis triad for ten to 15 years. Another patient developed the choroidal features of the syndrome in previously normal eyes. The basic lesion is a nodular choroidal infiltrate that evolves from clinically and angiographically normal retina. It is initially hypofluorescent and has an overlying serous detachment. It evolves through episodes of serous detachment and hyperfluorescence into a choroidal scar with breaks in Bruch's membrane and occasional subretinal neovascularization. Seven of 42 eyes (16.6%) developed new choroidal infiltrates in choroid and retina that were clinically and angiographically normal more than ten years ago. After ten years about 50% of eyes with central scars will have visual acuity changes of 3 or more lines because of progressive remodeling and extension of the disciform scar. Nine of 40 fellow eyes (22.5%) sustained a disciform process during the entire follow-up period. One patient developed typical choroidal lesions in previously normal fundi. Results of extensive physical and laboratory tests for histoplasmosis and other diseases were normal.

Adult↗
PubMed1980

Intraocular hemorrhage from vascularization of the cataract incision.

In a survey of 58 aphakic eyes examined 5 to 10 years after surgery, 12% had episcleral vessels in the inner aspect of the cataract incision and almost half of these eyes showed evidence of mild intraocular hemorrhage. Analysis of these and 33 other eyes indicates that argon laser treatment is only temporarily effective in preventing intraocular hemorrhage. Limbal cryotherapy is effective in a one- to four-year follow-up. While these vessels are a common cause of transient intraocular hemorrhage in aphakic eyes, serious sequelae are rare and treatment is usually unnecessary.

Aged↗
PubMed1979

Direct and indirect laser photocoagulation of central serous choroidopathy.

A 3 1/2-year prospective randomized clinical trial showed a definite superiority of direct argon laser photocoagulation to the fluorescein leaking site compared to indirect treatment away from the leak in patients with central serous choroidopathy. One patient in each treatment group developed a subretinal neovascular membrane after photocoagulation to the fluorescein leak. Moderate prolongation of the neurosensory detachment did not adversely influence the final visual acuity in the indirect treatment group. Although direct laser photocoagulation reduces the duration of central serous choroidopathy, there is a risk of producing subretinal neovascularization. The principles of risk vs benefit should be explained to all patients and treatment should be advised only for compelling reasons.

Adolescent↗