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Biomedical subjects

R C Thompson

Publications and source records attributed to R C Thompson.

At least 451 records · Page 25Linked to original sources

Uranium localization on hydroxyapatite by analysis of fission fragment tracks.

The distribution of enriched uranium on individual hydroxyapatite crystals after an exchange reaction has been investigated by means of thermal neutron irradiation followed by electron microscopic analysis of fission fragment tracks in plastic support films. One uranyl ion for every two to three surface calcium ions became associated with the mineral but in a nonuniform distribution that strongly favors crystal end regions.

Crystallography↗

Evidence for an extended active center in elastase.

Large increases in the esterase, amidase, and peptidase activities of elastase are observed on increasing the length of peptide substrates. The results suggest that at least five contiguous peptide units of the substrate (four N-terminal and one C-terminal to the scissile bond) can interact concurrently with the enzyme. When analyzed in terms of an acyl-enzyme mechanism, the increased effectiveness of the enzyme with larger substrates appears mainly in the acylation reaction and, to a lesser extent, in the binding and deacylation steps.

Amidohydrolases↗