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Biomedical subjects

R C Thompson

Publications and source records attributed to R C Thompson.

At least 343 records · Page 19Linked to original sources
PubMed1985

Perioperative anesthetic risk of noncardiac surgery in hypertrophic obstructive cardiomyopathy.

To determine their perioperative risk, we reviewed the records of 35 patients with hypertrophic cardiomyopathy diagnosed by cardiac ultrasound and/or catheterization who underwent general (52) or spinal (four) anesthesia--a total of 56 major surgical procedures. There were no operative or related perioperative deaths and no significant ventricular tachyarrhythmias. Intraoperative or postoperative complications included: myocardial infarction with heart failure in one patient who also had coronary artery disease and was one of three patients who had spinal anesthesia, arrhythmia requiring therapy in eight, and angina during supraventricular tachycardia in one. We conclude that the risk of general anesthesia and major noncardiac surgery is low in patients with hypertrophic obstructive cardiomyopathy. Spinal anesthesia, which decreases systemic vascular resistance and increases capacitance, may be relatively contraindicated. Concomitant coronary artery disease may increase the risk.

Adolescent↗
PubMed1985

Strain identification of Echinococcus granulosus in determining origin of infection in a case of human hydatid disease in Australia.

Viable parasitic material from cysts removed surgically from a human patient was used to differentiate the infecting strain of Echinococcus granulosus from another to which the patient may have been exposed. It was shown that the patient was infected with the Australian mainland domestic strain. The age of the cyst material was estimated by microscopical and histological examinations. Combination of these data with an investigation of the patient's life-history allowed identification of the most likely source of infection. Studies such as this help to define those areas of high risk for human hydatidosis on mainland Australia.

Australia↗
PubMed1985

Posterior surgical stabilization for atlantoaxial subluxation in rheumatoid arthritis.

Twelve patients with rheumatoid arthritis involving the cervical spine were treated with posterior surgical stabilization for atlantoaxial instability. There were two occiput C2 fusions with one death and ten C1-2 fusions with nine successful fusions, giving an overall 84% satisfactory results and 90% satisfactory results in the C1-2 fusions alone. It is proposed that careful attention to operative positioning and postoperative management are responsible for the better results reported in this series than recent reports of operative treatment of similar patients. The use of halo traction intraoperatively with careful attention to positioning of the neck and halo cast postoperatively are advocated.

Adult↗
PubMed1985

Hydatid disease: the alveolar variety in Australia. A case report with comment on the toxicity of mebendazole.

The alveolar form of hydatid disease, caused by the larval stage of the cestode Echinococcus multilocularis, is virtually confined geographically to the northern hemisphere. It produces clinically malignant multivesicular infiltrating lesions most often in the liver, and is quite different from the usual cystic variety caused by E. granulosus. We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.

Agranulocytosis↗
PubMed1985

Echinococcus granulosus in farm dogs and dingoes in south eastern Queensland.

Twenty-nine farms with a prevalence of greater than 20% of hydatidosis in cattle were visited in south eastern Queensland between August and December 1982. All farms carried beef cattle but none sheep. Twenty-four had dingoes and wallabies but only 8 had feral pigs. On 17 farms either macropods were killed for dog food or dogs were suspected of hunting macropods or scavenging their carcases. Purge samples were collected from 45 dogs from 23 of the 29 farms visited. The Australian sylvatic strain of Echinococcus granulosus was found in low numbers in purged intestinal content from one dog from each of 2 farms. Also, 50 intestinal tracts from dingoes from southern Queensland were examined between October 1981 and November 1983. The sylvatic strain of E. granulosus was found in 36 dingoes, the Australian mainland domestic strain in 4, and a further 5 dingoes were infected but the strain was not identified. This work indicates that domestic dogs are probably not important definitive hosts for E. granulosus in south eastern Queensland but could be an occasional source of infection for man. Dingoes are the major definitive host and worm numbers can be very high. Small foci of the domestic strain of E. granulosus may be maintained in a cycle involving dingoes, macropods and possibly feral pigs in cattle raising areas of coastal Queensland.

Animals↗
PubMed1984

Soft tissue sarcomas of the extremity. Is prognosis related to local environment?

Thirty-two patients with soft tissue sarcomas of the extremities were treated and retrospectively evaluated for the period from 1974 to 1978. Patients were treated by surgery with wide or radical margins or surgery with postoperative radiation therapy. Thirty-one patients were available with a minimum follow-up of 48 months. No significant difference could be detected between treatment modalities for continuous disease-free survival. The presence of tumor in muscular tissue gave a negative prognosis using multivariant discriminant analysis (P less than 0.05) with 39% of patients continuously disease-free at 48 months versus 77% of patients with tumors in nonmuscular tissue continuously disease-free. This observation suggests that the biologic milieu in which a soft tissue sarcoma grows may affect the course of the disease. These observations need to be confirmed by other investigators before using this criteria for treatment stratification.

Adolescent↗
PubMed1984

Ultrasonography of the rotator cuff: surgical correlation.

Rotator cuff tears are a common orthopedic problem. The portions of the cuff most commonly torn are accessible to sonographic examination with appropriate positioning of the shoulder. This study was undertaken to correlate the sonographic appearance of the pathologic rotator cuff with findings at the time of surgical repair. Rotator cuff tears are readily seen with high-resolution real-time sonography. Sonography can demonstrate tears not demonstrated arthrographically. In the appropriate clinical setting arthrography may not be necessary if the sonogram demonstrates characteristic findings.

Adult↗
PubMed1984

Fluorometric determination of DNA in cartilage of various species.

A sensitive, modified 3,5-diaminobenzoic acid (DABA), fluorometric DNA assay was developed and compared to mithramycin and ethidium bromide assays in determining the DNA content of dense connective tissues including: Swarm rat chondrosarcoma, rabbit, dog, monkey, and most importantly, adult human articular cartilage. In the more cellular cartilages, the three methods gave equivalent results. However, in the relatively acellular human cartilage, the DABA method was shown to be superior. Both the mithramycin and ethidium bromide gave falsely high values compared to the DABA method, which by subtraction after DNase digestion approached the DABA value. The latter was completely DNase sensitive. With the DABA method, the DNA content of human cartilage can be obtained on less than 5 mg wet weight of fresh, alcohol-fixed, or lyophilized material. While the DNA can also be released by digestion with papain or protease from Streptomyces griseus, proteinase K was preferable. The comparison of literature values for other fluorometric and spectrophotometric assays of human cartilage suggest these methods overestimate human articular cartilage DNA concentrations, whereas the DABA values were in line with those predicted from previous morphometric analysis. Thus, the modified method represents an improvement in DNA analysis of dense connective tissues.

Adult↗
PubMed1984

Prevalence and survival of Toxocara canis eggs in the urban environment of Perth, Australia.

Using a technique of proven efficiency no Toxocara canis eggs were recovered from a total of 266 sand samples collected from "dog beaches" and parks in the Perth urban area. This observation emphasises that the major risk to humans is from an environment in which puppies are found. Other observations, made at a heavily contaminated site, showed that the eggs of T. canis disappeared from sandy soil over about 6 months during a period in which it would have been expected that conditions were favourable for egg survival. Other data are also presented indicating that the prevalence of T. canis in adult dogs in Perth is quite low. However, T. canis eggs were recovered in large numbers from the majority of soil samples collected from Perth dog-breeding establishments.

Animals↗
PubMed1983

Presumed neurotrophic skeletal disease in diabetic kidney transplant recipients.

A retrospective review of kidney transplant cases from 1969 to 1974 revealed a 20% incidence of neuropathic skeletal disease among diabetic patients, with the highest incidence occurring in the third and fourth years after transplantation. There were no identifiable differences in immunosuppressive drug management and sex predilection among nondiabetic kidney transplant recipients and the diabetic kidney transplant recipients. The presence of painless swelling in the lower extremity of these at-risk patients should be considered an early sign of impending pathological fracture, joint disruption, or both.

Age Factors↗