Embryo transplants: ethical stance needed.
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Biomedical subjects
Publications and source records attributed to R C Shaw.
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Toxic shock syndrome is a rapidly developing disease which may be lethal if not recognized and treated early. While this disease is usually associated with menstruating females, it is being seen in both male and female patients following clean, elective surgery. Toxic shock syndrome has been reported following surgical procedures which normally have a very low incidence of postoperative wound infections. Toxic shock syndrome is associated with Staphylococcus aureus bacteria which produce the toxic shock syndrome toxin 1. Three patients with postoperative toxic shock syndrome, of varying degrees of severity, are presented. Prompt institution of resuscitative and therapeutic measures can prevent the potentially fatal outcome of this postoperative complication.
Nineteen young Hereford bulls were used to study the relationship between semen characteristics and fertility in artificial insemination following 15 320 inseminations. Seven measures of sperm motility, morphological abnormalities, the release of hyaluronidase, ATP content and sperm head measurements were examined as predictors of fertility (49-day fixed-interval non-return rate). Two assessments of motility, three categories of abnormal spermatozoa, acrosomal changes and the release of hyaluronidase had predictive power. Multiple regression analysis showed that a combination of sperm motility after dilution in saline, motility after thawing and the proportion of coiled tails and proximal protoplasmic droplets provided the best prediction of fertility and allowed bulls to be ranked in order of observed non-return rate (%) with a Spearman correlation better than +0.80.
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Posterior ventricular aneurysm and severe mitral regurgitation due to acute myocardial infarction are rarely recognized during life. This report describes the successful surgical treatment of a patient with this combination of lesions who at operation was found to have rupture of the left ventricle as well. Aneurysmectomy, mitral valve replacement, and coronary artery bypass were performed with a gratifying late result. Aggressive investigation of patients with hemodynamic deterioration after posterior myocardial infarction may identify surgically correctable mechanical complications.
Forty-four patients had resection of a chronic postinfarction left ventricular aneurysm. Operative indications were heart failure, angina, and ventricular arrhythmias. Twenty-six patients (59%) had coronary grafting in addition to aneurysmectomy. The operative mortality rate was 4.5% (2/44), and late mortality (mean follow-up, 31 months) was 17.9% (7/39). Preoperatively all patients were in New York Heart Association Functional Class III or IV; 91% were Class I or II postoperatively. Coronary bypass grafting did not increase the operative mortality rate, and long-term survival was similar between those receiving coronary grafts and those not receiving grafts. Postoperative ventriculograms were evaluated in 10 patients by means of a system of internal grids. Amount of regional myocardial contraction correlated well with the patient's postoperative functional capacity. It is concluded that ventricular aneurysmectomy in combination with coronary bypass grafting is safe and effective, resulting in marked improvement in the patients' functional capacity and longevity.
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Life-threatening complications involving the central circulation commonly occur in uremic patients. The growing number of individuals maintained on long-term hemodialysis along with repeated demonstrations of their ability to tolerate major operative procedures are responsible for increasing surgical experience in this group. Despite a high incidence of subacute bacterial endocarditis (SBE) and accelerated coronary atherosclerosis, exposure of such patients to open-heart operations has been limited. Our management of two patients who recently underwent valvular replacement is outlined and a review of the literature revealed that, during the past decade, 20 uremic patients have undergone a variety of cardiac procedures. The catastrophic results of medical therapy in such individuals with SBE are emphasized and early surgical intervention is recommended.
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We reviewed 35 patients undergoing resection of a chronic postinfarction left ventricular aneurysm. There was 5.7% operative mortality. Of the long-term survivors, 80% are functional class I or II. Ten patients had postoperative left ventriculograms studied by means of a computerized analysis of endocardial motion using internal orthogonal and radial grids. Postoperative end-diastolic volumes were much greater than normal and large akinetic areas were present although there was good improvement in the patient's functional capacity. Grid analysis of endocardial motion correlated better with the patient's postoperative clinical status than did measurements of end-diastolic pressure and volume, ejection fraction, or visual inspection of the postoperative left ventriculogram.
The case of a young woman, receiving oral contraceptives, who developed massive pulmonary embolism producing circulatory collapse and paradoxical arterial embolism through a patent foramen ovale is documented.. Limb viability was threatened. Emergency management included removal of arterial and pulmonary emboli, surgical closure of the patent foramen ovale, inferior caval partitioning, ovarian vein ligation, and short-term anticoagulation. Recovery was rapid and complete.
Uremic pericarditis developed in 37 of 295 patients (8 percent) admitted to the chronic hemodialysis program at our institution. Sixteen patients (43%) underwent limited pericardiectomy through a left anterior thoracotomy approach with no operative deaths and minimal morbidity (19%). Twenty-one patients (57%) were treated successfully with intensive hemodialysis. The use of pericardiocentesis did not avert cardiac tamponade in any patient in our series. The procedure was associated with two life-threatening complications and its use, therefore, has been limited in the therapy of uremic pericarditis. We recommend surgical intervention in all patients with hemodynamic instability and echocardiographic evidence of enlarging effusions or an effusion unchanged in size following 10 days of intensive hemodialysis.
Peripheral extravasation of intravenous solutions containing calcium salts and/or 10% dextrose has caused significant local tissue necrosis in 8 patients, including 6 infants. These incidents prolonged hospitalization and in 5 cases caused severe disfigurement or imperiled limb function. Treatment followed established principles of debridement, early skin grafting and secondary reconstruction as needed. While intravenous alimentation or the administration of calcium salts if often indicated by the clinical situation, the physician administering these drugs must realize that extravasation may cause serious sequelae.
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The coronal incision approach to Le Fort III fractures gives excellent exposure for anatomical reduction and internal fixation of the fracture sites. Either an extracranial, or a combined intracranial procedure, is feasible. The exposure obtained not only facilitates the reduction and the fixation but, with the addition of transconjunctival incisions, the patient benefits by not having multiple surgical scars in the face.