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Biomedical subjects

R C Sharma

Publications and source records attributed to R C Sharma.

At least 181 records · Page 10Linked to original sources
PubMed1978

Third generation infantile syphilis--an unusual presentation.

A case of third generation early congenital syphilis with unusual features is reported and discussed. The infant presented with Livedo reticularis and an ulcer on the right forearm since birth; the underlying radius and ulna showed osteomyelitic changes with sequestrum formation and a pathological fracture. The rest of the skeletal system was normal. The blood STS (VDRL) was reactive at 1:64. The child showed no other evidence of congenital syphilis. Livedo reticularis and bony lesions resolved promptly with penicillin therapy, but abnormal movements at the wrist joint persisted. The mother had pathognomic Hutchinsonian incisors and a reactive VDRL test.

Follow-Up Studies↗
PubMed1975

Fluorinated quinazolones III: synthesis and CNS depressant activity of fluorinated quinazolone derivatives.

The synthesis of 2-allylthio-3-(4'-fluorophenyl)-5,6,7,8-tetrafluoro-4-quinazolone, 2-n-propylthio-3-(4'-fluorophenyl)-5,6,7,8-tetrafluoro-4-quinazolone, 3-(4'-bromophenyl)-5,6,7,8-tetrafluoro-2,4-quinazolinedithione, and seven fluorinated 2-alkyl/phenyl-3-aryl-4(3H)-quinazolones is described. The synthesized compounds were screened for CNS depressant activity using pentobarbital sleeping time, pentylenetetrazol convulsions, and condition avoidance test as the parameters. Most of the screened compounds exhibited significant depressant activity.

Animals↗
PubMed1975

Microbiology of cutaneous tuberculosis.

Detailed bacteriological characteristics including drug sensitivity of 12 mycobacteria isolated from 51 cases of different types of cutaneous tuberculosis were studied; no mycobacterium could be isolated from remaining 39 cases. Nine were identified as M. tuberculosis and 3 as 'anonymous' mycobacteria. Acquired resistance to one or more than one drug (streptomycin, isoniazid, PAS and thiacetazone) was observed in 3 out of 9 strains of M. tuberculosis. All the 'anonymous' strains were resistant to all the drugs except ethionamide and ethambutol.

Aminosalicylic Acids↗