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Biomedical subjects

R C Noble

Publications and source records attributed to R C Noble.

At least 55 records · Page 3Linked to original sources
PubMed1993

Alpha-tocopherol absorption and polyunsaturated fatty acid metabolism in the developing chick embryo.

1. A study has been made relating alpha-tocopherol uptake from the yolk and yolk sac membrane to the polyunsaturated fatty acid status of the liver during incubation. 2. Whereas at day 15 of incubation lipid in the liver showed an exceedingly high degree of unsaturation and potential for oxidation because of accumulation of C20 and C22 polyunsaturated fatty acids, alpha-tocopherol concentrations were exceedingly low. 3. In contrast, very high concentrations of alpha-tocopherol occurred within the liver just before hatching by which time amounts of polyunsaturates and the need for oxidation protection had reduced considerably.

Animals↗
PubMed1991

Effect of aging on cold tolerance and thyroid activity in CBA/Ca inbred mice.

Relationships between cold tolerance, serum levels of thyroxine (T4), thyronine (T3), and thyrotropine (TSH), and thyroid morphometry have been investigated in male CBA/Ca inbred mice at various ages through their life span. From the data obtained it appeared that there was an age-related decrease in cold tolerance up to 18 months of age which was followed by an increase, the age effect being most apparent in relation to cold resistance and cold tolerance during the recovery period following cold exposure. The age-related changes in cold tolerance appeared to be associated with changes in the serum concentrations of T3, T4, and TSH. In contrast to the T3 serum levels which showed a decrease at 36 months, the thyroxine contents showed a perceptible decrease from the age of 12-18 months onwards. A similar pattern was observed for the TSH levels, with a peak at 21 months, followed by a decline at 30 months. A relationship with age between serum T4 level and thyroid weight was indicated together with structural changes in the thyroid gland, particularly during senescence, for example the size and number of thyroid epithelial cells had become enlarged by 30 months of age.

Acclimatization↗
PubMed1990

Sequelae of sexually transmitted diseases.

The sequelae of sexually transmitted diseases most seriously affect women and their infants. Pelvic inflammatory disease with associated ectopic pregnancy and infertility leads the list. Male infertility as a result of sexually transmitted diseases appears uncommon.

Female↗
PubMed1989

Clinical comparison of single-oral-dose cefuroxime axetil and amoxicillin with probenecid for uncomplicated gonococcal infections in women.

Four hundred sixty-six female patients were enrolled in a randomized study that compared the clinical efficacies of single oral doses of cefuroxime axetil and amoxicillin with probenecid in the treatment of uncomplicated gonorrhea. Two hundred ninety-five patients had culture-positive gonococcal infections and completed the investigation. Cure rates for the patients treated with cefuroxime axetil and those treated with amoxicillin with probenecid were high (greater than 95%) for genitorectal infections. Pharyngeal infections, however, were not uniformly eradicated by either cefuroxime axetil (60%) or amoxicillin with probenecid (64%). Approximately 13% of each patient group suffered adverse events, which were gastrointestinal in the majority and were transient. Compared with amoxicillin plus probenecid, cefuroxime axetil in a single oral dose was an equally safe and effective drug for the treatment of uncomplicated gonorrhea in women caused by penicillin-susceptible strains.

Adolescent↗
PubMed1989

Lipid changes in the residual yolk and liver of the chick immediately after hatching.

A study has been made of the changes in the weights, lipid and fatty acid compositions of the liver and residual yolk complex of the chick during the immediate period following hatching. By the 5th day after hatching about 85% of the gross weight and 90% of the lipid associated with the yolk complex had been absorbed. During this period, the composition of the yolk lipid displayed a marked increase in its proportion of cholesteryl esters and decreases in the triacylglycerides and phosphoglycerides. Whereas, in the triacylglycerides of the residual yolk after hatching there were changes in the proportions of the saturated fatty acids, in the phosphoglycerides there were distinctive changes in the proportions of the polyunsaturated fatty acids. Growth of the liver after hatching was associated with a substantial accumulation of fat. The very high level of cholesteryl esters associated with the embryonic liver was rapidly replaced by triacylglycerides in particular, and phosphoglycerides. The accumulation of the triacylglycerides was accompanied by a rapid change in their fatty acid composition away from that associated with embryonic development and differing markedly from that of the triacylglycerides being absorbed from the yolk. The changes in the lipid and fatty acid composition of the liver were indicative of the rapid alteration for the role of the liver in the lipid metabolism of the newly hatched chick.

Animals↗