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Biomedical subjects

R C Neafie

Publications and source records attributed to R C Neafie.

36 records · Page 2Linked to original sources
PubMed1983

Sowda--onchocerciasis in north Yemen: a clinicopathologic study of 18 patients.

Sowda is an unusual form of onchocerciasis in Yemenites that differs from African onchocerciasis. Clinical and pathological studies were performed on 18 patients in Yemen Arab Republic (North Yemen). Biopsies of skin and lymph nodes were taken, and then processed at the Armed Forces Institute of Pathology, Washington, D.C. The most striking clinical features were swollen, darkened, pruritic, papular skin changes that were usually limited to one leg, more rarely to one arm, and large soft regional lymph nodes. Dermal changes were deeper and more diffuse than in African onchocerciasis, with many large fibroblasts and plasma cells. Microfilariae of Onchocerca volvulus were much rarer in skin from Yemenites with sowda. When patients were treated with diethylcarbamazine, the dermatitis became suddenly worse as the microfilariae degenerated and provoked acute inflammation. The dermatitis decreased after several days of treatment. Enlarged lymph nodes from sowda have shown follicular hyperplasia, in contrast to follicular atrophy and perivascular fibrosis that are characteristic of lymph nodes from cases of African onchocerciasis. Cell-mediated and humoral immunity may be more active in sowda than in African onchocerciasis.

Adolescent↗
PubMed1980

Subcutaneous dirofilariasis of the eyelid and ocular adnexa. Report of six cases.

Six cases of subcutaneous dirofilariasis are reported, three located in the eyelid, two in the periorbital region, and one in the subconjunctival tissues. Three patients lived in Florida, two in North Carolina, and one in Mississippi. All patients were adults, ranging from 27 to 69 years of age (median age was 58 years). Most patients experienced an inflamed painful nodule that contained portions of a nematode. The morphologic features for identification of the worm as belonging to the genus Dirofilaria are outlined.

Adult↗
PubMed1977

Streptocerciasis: observation of adult male Dipetalonema streptocerca in man.

In 75 biopsy specimens of skin from 34 patients with streptocerciasis who had been treated with diethylcarbamazine, we found 39 female and six male adult Dipetalonema streptocerca in the dermal collagen. This is the first report of adult male D. streptocerca in man, and identifying features are described.

Animals↗
PubMed1977

Onchocerciasis: invasion of deep organs by Onchocerca volvulus.

Autopsies of two patients with onchocerciasis in the Republic of Zaïre are reported. In one patient elephantiasis who died following diethylcarbamazine therapy there were large numbers of microfilariae of Onchocerca volvulus in the kidney, liver, pancreas, and lung. In the second patient, who also had leprosy and hyperinfection strongyloidiasis, we found an encapsulated adult O. volvulus in the wall of the thoracic aorta.

Aorta, Thoracic↗
PubMed1976

Humoral immunity of parasitized, malnourished children.

The nutrition, intensity of parasitism, complete blood count, and the serum immunoglobulin concentration of 63 children were studied. Hyperimmunoglobulinemia was present in the vast majority of subjects regardless of their nutritional status. The IgA and IgM concentrations were moderately increased, the IgG was increased threefold, and the IgE was markedly increased in concentration. The concentrations of the immunoglobulins were related significantly to the intensity of parasitism.

Ascariasis↗
PubMed1976

Disseminated parasitosis in an immunosuppressed patient. Possibly a mutated sparganum.

The autopsy of a man who died of Hodgkin disease revealed that a peculiar metazoan parasite had proliferated and disseminated throughout his body. The parasite could not be identified; however, electron microscopical studies revealed that it had the structure of a flatworm. This, together with its shape and structure, convinced us that the parasite was an aberrant sparganum manifesting uncontrolled proliferation and dissemination.

Blood Vessels↗
PubMed1975

Human pulmonary dirofilariasis. A case report and review of the literature.

A case of pulmonary dirofilariasis in a 48-year-old woman is presented. This rare pulmonary disorder is caused by Dirofilaria immitis, the canine heartworm. A review of the literature revealed 40 documented cases, most of which have occurred in the United States within the past 10 years. The incidence of pulmonary dirofilariasis appears to be increasing; thus, this entity represents an important zoonosis and indicates a need for familiarity with the pathologic features of the lesions and the morphologic characteristics of the worm.

Adult↗
PubMed1975

Dipetalonema streptocerca (Macfie and Corson, 1922): description of the adult female.

Morphologic features of the adult female Dipetalonema streptocerca and microfilariae are described and illustrated from serial paraffin sections of biopsied skin from eight Africans. Characteristic features include a maximum diameter of 85 microns, a thin, smooth cuticle, and uteri that fill the body cavity. D. streptocerca is briefly compared to Onchocerca volvulus.

Animals↗
PubMedDate not supplied

Dicroceliasis (lancet fluke disease) in an HIV seropositive man.

Dicroceliasis is an unusual zoonotic trematode infection caused by the lancet liver fluke, Dicrocoelium dendriticum. Grazing herbivores (usually sheep or cattle) are the definitive hosts. The life cycle proceeds through two intermediate hosts: the land snail and the field ant. Human infection is acquired by consuming the field ant. This case report describes a human immunodeficiency virus-seropositive patient who presumably acquired this parasite from bottled water contaminated with ants. A brief discussion of the parasitology, pathology, clinical findings and treatment is presented.

Adult↗