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Biomedical subjects

R C Moore

Publications and source records attributed to R C Moore.

At least 73 records · Page 4Linked to original sources
PubMed1982

Prognostic indices in the treatment of acute diverticulitis: a retrospective study.

A review of patients with acute diverticulitis admitted to the University of Maryland Hospital over the past ten years revealed a high frequency of surgical intervention. In addition to the usual indications for surgery (obstruction, perforation, and fistula), we found persistent mass combined with other clinical indices, such as fever, leukocytosis, tachycardia, or recurrence required surgical intervention. Medical therapy (i.e., intravenous hydration, antibiotics, diet, nasogastric suction, etc.) varied with the clinical presentation. Only 43 per cent of the medically treated patients received antibiotics. If the bowel can be adequately prepared, a one-stage operation may be possible. Otherwise more stages may be necessary. A prognostic index has been devised for acute diverticulitis for the evaluation of medical vs. surgical therapy. The higher the index, the more extensive the procedure that will be used. Our study supports the general usefulness of a Hartman (two-stage) procedure for those patients requiring surgery.

Acute Disease↗
PubMed1981

Effects of 1-beta-D-arabinofuranosylcytosine on chromosomes, depending upon the cell cycle stage at the time of exposure.

1-beta-D-Arabinofuranosyl cytosine (ara-C) is a clinically important cytotoxic drug which is a potent inhibitor of DNA but which has a minimal effect on other cellular processes. The cytotoxic action of ara-C on mammalian cells has been suggested to be due to the chromosome aberrations induced by this compound. Using a marsupial cell line (JU56), the cells of which contain only 9 readily identified chromosomes, the different types of chromosome aberrations induced by a pulse of ara-C have been quantified, and the cell cycle dependence of the damage has been assessed. It was found that, for cells exposed in G2, both chromatid-type and chromosome-type lesions were produced. The frequency of these lesions was reduced by a chase of deoxycytidine, and there was some evidence that the initial lesions are gaps which may later be converted to true breaks. In early G2 and late S cells, lesions were produced chiefly at one chromosome locations; this location was not specifically late-replicating. At all stages of S, lesions were chiefly chromatid-type, and some exchanges occurred. The level of damage in S cells was not influenced by a deoxycytidine chase. There was negligible damage in cells exposed in G1. It is suggested that the reason previous investigators have obtained very different cell cycle dependence of chromosome damage is that the delaying effects of ara-C on cell cycle progression was not taken into account.

Animals↗
PubMed1979

Studies of X-ray-induced chromosome aberrations in cells of the black-tailed wallaby. I. Non-random exchange in peripheral blood cells irradiated in Go.

The distribution of exchanges between individual chromosome arms in mitotic peripheral blood cells following X-irradiation in Go has been measured. It was found that, although all arms exchanged with each other, there were small but significant departures from the frequencies expected on the basis of random breakage and exchange. It is suggested that non-randomness may reflect the non-uniform state of condensation of chromatin in Go lymphocytes.

Animals↗
PubMed1979

Malignant hyperthermia. Report of two cases.

A dentist using local or general anesthetics must be cognizant of the possibility of malignant hyperthermia presenting as a catastrophic emergency. The purpose of this article is to describe the syndrome of malignant hyperthermia, to emphasize its early clinical symptoms, and to outline definitive treatment. Two cases of malignant hyperthermia in pediatric dental patients illustrate the clinical and laboratory features and the appropriate therapy.

Anesthesia, Dental↗
PubMed1979

Legal implications of the pharmacist's expanded clinical roles: a challenge to the clinical pharmacist's competencies.

Various sources have put forward the pharmacist as a clinician in addition to traditional functions. These expanded duties have been described as being beneficial to the health care system. This paper describes a project involving the clinical judgment and expertise of the doctor of pharmacy. The project validity and the competency of the doctor of pharmacy program(s) were challenged in the federal courts. The ruling in the case suggests a legal challenge to the pharmacist's clinical function(s).

Drug Prescriptions↗