Stabilization of the midface with a cranium-to-alveolus bone graft.
The cranium-to-alveolus bone graft is an alternate method of reconstructing the posterior and lateral midfacial pillars where local reconstruction is not possible.
Adult↗
Biomedical subjects
R C Mixter
Publications and source records attributed to R C Mixter.
Desmoplastic melanoma of the head and neck.
The pathologic and clinical findings in cases of desmoplastic melanoma of the head and neck seen at the Mayo Clinic in Rochester, Minnesota, during the past 20 years were analyzed. The nine cases acceptable for study included six usual and three neurotropic variants as defined by light microscopic criteria. Immunopathologic studies of all cases using S-100 protein and desmin, and electron microscopy in four cases, were unsuccessful in distinguishing between the two subtypes. Clinical behavior was aggressive regardless of histologic subtype. Extensive surgical treatment when the diagnosis is made is advocated. The combination of the rarity and the subtle histologic features of desmoplastic melanoma continues to make the correct diagnosis of this entity a challenge for the clinician and pathologist.
Aged↗
Closure of a defect of the femur with a compound free forearm transfer including both the radius and the ulna.
We report our experience of a patient with a most unusual and unfortunate combination of injuries. We feel that this case demonstrates not only the value of vascularised bone grafts in the treatment of large defects but also the imaginative use of seemingly useless parts in surgical reconstruction.
Adult↗
Nasal bone grafting using split skull grafts.
The nose has been reconstructed with bone grafts, cartilage, and silicone. Each of these methods has disadvantages, but the bone graft is most trouble free. It is possible to take a split skull graft with a high speed drill and an osteotome. The position of the graft site on the skull determines its shape. This can be tailored to the desired nasal contour. Several grafts may be used to build up the nasal dorsum further. This method has been used in patients suffering from acute trauma and deformities resulting from previous trauma, rhinoplasty, congenital anomalies, and after cancer resection. Apart from 1 scalp wound infection, there have been no complications in 24 cases. The degree of bone graft resorption has been minimal, and the level of patient satisfaction has been high.
Adult↗
Making the most of the gastrocnemius muscles.
The two heads of the gastrocnemius muscle are easily mobilized and very dependable. It is our first choice for local muscle transpositions in and about the knee. Thirty-four consecutive gastrocnemius muscle flaps performed on one service are evaluated. Seven maneuvers and some technical points are presented and illustrated to enable the surgeon to get the most possible use of these two reliable structures.
Adolescent↗
Aminergic and thermoregulatory mechanims in hypothalamic regulation of growth hormone in cats.
In conscious cats intravenous infusion of L-dopa (20 mg/kg) increased plasma growth hormone (GH), hydrocorticosterone (17-OHCS), and glucose while lowering midbrain (core) temperature (Tmb). Peripheral blockade of aromatic amino acid decarboxylase by L-alpha-hydrazino-methyldopa (MK 486) abolished only L-dopa hyperglycemia, indicating CNS stimulation by de novo catecholamines caused endocrine and temperature changes. Phenoxybenzamine but not pimozide pre-treatment abolished GH release after L-dopa. Apomorphine infusion alone did not alter basal GH. These data indicate central alpha-adrenergic mediation of GH release. Norepinephrine (NE) injected (5 or 10 microgram) into the preoptic anterior hypothalamus (POAH) (7 of 10 cases) and medial hypothalamus (17 of 30) raised GH while lowering Tmb, in agreement with alpha-adrenergic mediation. Responsive sites were distributed in ventral and dorsal medial hypothalamus and extended into the thalamus. Cooling of the POAH by implanted thermode raised GH in association with shivering, vasoconstriction, and rise in Tmb. Correlation between GH release and change in Tmb after L-dopa, central NE injection, and POAH cooling suggests hypothalamic integration of GH release with thermoregulation. Intravenous infusion of 5-hydroxytryptophan after MK 486 raised GH and 17-OHCS, suggesting serotonergic mechanisms also control GH and ACTH.
18-Hydroxycorticosterone↗