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Biomedical subjects

R C Mitchell

Publications and source records attributed to R C Mitchell.

23 records · Page 2Linked to original sources
PubMed1984

The metabolism in animals and man of oxmetidine--a new histamine H2-receptor antagonist.

The absorption, distribution, metabolism and excretion of [14C]oxmetidine in rat, dog and man has been studied following both i.v. and oral administration. Excretion is rapid and essentially complete in all three species. The biliary route is predominant. Distribution of radioactivity is widespread although none is seen in the brain. Metabolite patterns in urine from rat, dog and man have been compared by thin-layer chromatography. Metabolite patterns in urine and bile from rat and dog have been compared by high pressure liquid chromatography. Six major metabolites have been isolated and identified including two O-glucuronides and one N-glucuronide.

Absorption↗
PubMed1984

Nitrosation of peptides.

The synthesis and characterization of N-(N-acetylprolyl)-N-nitroso-glycine, the first authentic N-nitrosopeptide, is described, and its stability under various conditions is reported. In acidic media, denitrosation and deamination (hydrolysis) occur concurrently, whereas in neutral and alkaline solutions, only deamination occurs. The rates of formation and decomposition of some unprotected N-nitrosopeptides in strong acid are also reported. Conditions for the formation of such compounds in the gastric tract are discussed, together with their potential involvement in human cancer.

Chemical Phenomena↗
PubMed1978

Hospitalwide inventory turnover gives hospitals positive results.

This article describes the problems involved in reaching a rational inventory investment and describes a hospitalwide inventory turnover program that can be used as an aid in reaching this decision. The article illustrates a hospitalwide inventory program at one hospital. The systematic program entails the collection of data, review of the data to develop a program for reducing inventories, and monitoring of the results.

Arizona↗
PubMed1972

Polysome Formation in Light-controlled Dormancy.

Lettuce (Lactuca sativa) seeds var. Grand Rapids could be maintained many weeks in the dark without germination. Following illumination with white light, a gradual increase in polyribosome population up to the time of germination was demonstrated by sucrose gradient centrifugation. Polysomes could not be detected in imbibed seeds maintained continuously in the dark. Thus, polysome formation and therefore the capacity for a high rate of protein synthesis required for germination and growth, is not associated with the process of imbibition, but is dependent upon the seeds having received the dormancy-breaking stimulus of illumination.

Journal Article↗