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Biomedical subjects

R C Martin

Publications and source records attributed to R C Martin.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Short-term retention of lexical-semantic representations: implications for speech production.

Patients with semantic STM deficits have difficulty comprehending sentences that require the retention of several lexical-semantic representations prior to their integration into higher-level propositions (Martin, 1995: Martin & Romani. 1994). In Experiment 1, patients with a semantic retention deficit had difficulty with the same type of constructions in speech production, namely noun phrases with one or two prenominal adjectives. Their performance improved when they could produce the nouns and adjectives in sentence form, which placed smaller demands on lexical-semantic retention. In Experiment 2 these patients were better able to produce syntactically complex sentences than the prenominal adjective phrases having an equal number of content words, indicating that the findings in Experiment 1 could not be attributed to syntactic complexity. These patients produced more pauses in the sentence constructions in Experiments 1 and 2, suggesting that the timing of such productions is abnormal. In contrast, patient EA, with a phonological retention deficit, performed better than the patients with a semantic retention deficit on the AN phrases despite having a smaller STM span. She showed no significant benefit of producing sentence compared to phrase constructions, and also made fewer and shorter pauses than the other patients. These findings support the multiple capacities view of verbal working memory and suggest that the same semantic retention capacity used in language comprehension is used in speech production.

Aged↗
PubMedDate not supplied

Diagnostic and operative arthroscopy of the knee under local anesthesia with parenteral medication.

Arthroscopy of the knee under local anesthesia was performed on 102 patients for operative and diagnostic purposes between January and December of 1985. The procedures were performed on a same day basis without a pneumatic tourniquet. The operative record of each patient was reviewed to determine postoperative diagnosis and treatment. The data was matched to a patient questionnaire that measured individual reaction to local anesthesia. The effectiveness and level of patient acceptance of this anesthetic technique for operative arthroscopy was then evaluated. Ninety-one patients responded to the questionnaire, 82 of whom had prior anesthetic experience. Ninety-five percent of the patients had minimal or no discomfort during the procedure. Eighty percent indicated a preference for local anesthesia in the event of subsequent arthroscopy. No complications relating to the anesthetic agent were noted. Arthroscopy of the knee under local anesthesia for routine operative arthroscopy was found to be safe, reliable, practical, and to have a high patient acceptance rate.

Adolescent↗
PubMedDate not supplied

Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence.

Giant cell tumor of the tendon sheath (GCTTS), tenosynovial giant cell tumor (TGCT), and pigmented villo-nodular synovitis (PVNS) are the common names for a group of rare proliferative disorders that involve synovial joints and tendon sheaths. Considerable confusion exists about the surgical treatment and diagnosis of these disorders. This review evaluates the presentation, surgical therapy and recurrence of these three proliferative disorders. We retrospectively reviewed the clinical data from all cases of GCTTS, TGCT, and PVNS from 1985 to 1997. A total of 35 patients were identified: GCTTS (n=8), TGCT (n=1), and PVNS (n=26), there were 18 men and 17 women. The median age was 48 years (range 6-84 years). The most common site of involvement was the knee (15), followed by wrist (7), elbow (4), and hip (4). Seven patients had extra-articular involvement, and 19 were found incidentally at operations for other reasons. Among the 4 patients who developed recurrent disease, 2 had extra-articular disease at the time of their original diagnosis. None died, and none required major amputation. One patient was treated with adjuvant radiotherapy following resection of a recurrence. It is important to distinguish between focal and diffuse forms of synovial involvement. If focal, simple surgical excision is appropriate. If diffuse, complete synovectomy is indicated for disease confined to the joint, and resection of all gross disease is indicated for extra-articular disease. Radical resection with negative margins is not necessary in most instances. In rare aggressive cases, local recurrence may necessitate more extensive resection and radiation therapy.

Female↗
PubMedDate not supplied

[Dynamics of calcitonin secretion in tissue culture of medullary thyroid carcinoma].

Calcitonin secretion dynamics of a medullary thyroid carcinoma in tissue culture was studied by addition of calcium chloride (20 mM), magnesium chloride (20 mM), glucagon (6 x 10(-6) M), and pentagastrin (3 x 10(-6) M). After correction by protein content, calcium caused the greatest release of calcitonin to medium (264%), and glucagon the lowest (48%), in relation to control values. The direct action of glucagon on calcitonin secretion of medullary thyroid carcinoma was confirmed. This system may be also used for testing quimiotherapics acting upon the tumor.

Calcitonin↗