Behavioural deficit in the rat induced by feeding phenylalanine.
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Biomedical subjects
Publications and source records attributed to R C Leaf.
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Mouse-killing in rats was gradually inhibited by repeated posttest injections of d-amphetamine (1.5 mg/kg), l-amphetamine (1.5 mg/kg) or pilocarpine (7.5 mg/kg), but not by control substances. Of these drugs, only d-amphetamine inhibited killing when given prior to a mouse-killing test. Further experiments suggested that anorexia per se did not contribute to drug-induced inhibitory effects, but that changes in internal state were important to the development of inhibition. Pretest injections appear to inhibit predatory killing by a direct pharmacological action on some target site or sites, while posttest injections produce a learned aversion to predatory killing.