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Biomedical subjects

R C Jones

Publications and source records attributed to R C Jones.

301 records · Page 17Linked to original sources
PubMedDate not supplied

Evaluation of axillary lymphadenectomy without axillary drainage for patients undergoing breast-conserving therapy.

BACKGROUND: The routine use of drainage after axillary node dissection in patients undergoing breast-conserving therapy (BCT) is being questioned. To determine the value of routine drainage, we evaluated the postoperative course of patients with primary breast carcinoma who underwent axillary dissection with or without axillary drainage. METHODS: A retrospective review of 69 patients prompted a prospective randomized trial of 46 patients undergoing BCT at our tertiary cancer center. Variables studied were age, treatment (drain or no drain), number and tumor status of excised lymph nodes, size of primary tumor, duration of drainage or aspiration, number and volume of aspirations, number of office visits, incidence of complications and degree of pain, change in arm or forearm circumference, and body mass index (BMI). Data from prospective and retrospective studies were pooled for analysis. RESULTS: Of 115 patients, 72 were treated with a drain (Drain group) and 43 were not (No-drain group). Overall there was no difference in the number or tumor status of excised nodes, the size of the primary tumor, or the incidence of complications between the two groups. Aspiration was required in 50% of the No-drain patients and 8.3% of the Drain patients. The incidence of drain placement or replacement postoperatively was 9.3% for the No-drain patients and 4.2% for the Drain patients. The No-drain patients had more office visits (5.1 +/- 0.4 vs. 3.6 +/- 0.1; P = .0002) and a longer interval between operation and last aspiration or drain removal (16.2 +/- 1.4 days vs. 11.3 +/- 0.6 days; P = .0040). Findings were similar in the subgroup of 46 prospectively studied patients, who included 24 Drain patients and 22 No-drain patients. In this group, pain evaluation using a scale of 0 to 10 showed a mean rating of 4.2 +/- 2.6 in Drain patients and 2.7 +/- 0.4 in No-drain patients (P = .0062). CONCLUSIONS: Axillary node dissection can be managed with or without a drain. More office visits but less pain can be expected if a drain is not used.

Arm↗
PubMedDate not supplied

The effects of three reproductive hormones and cortisone on the replication of avian infectious bronchitis virus in vitro.

The in-vitro effects of three reproductive hormones (progesterone, oestrogen testosterone), and cortisone on the replication of infectious bronchitis (IB) virus strain G were investigated over a period of 36 hours using tracheal organ cultures as the culture system. The non-toxic concentration of each hormone for the culture system was first determined. These were found to be 3 micrograms/ml for progesterone, testosterone, and cortisone, and 1 micrograms/ml for oestrogen. The results were based on the assay of the extracellular virus production from both hormone treated and untreated infected cultures at specific intervals up to and including 36 hours. While oestrogen, testosterone, and cortisone were found to enhance the replication of the virus, no significant effect was noticed following treatment with progesterone.

Cortisone↗
PubMedDate not supplied

Early pathogenesis in chicks of infection with an enterotropic strain of infectious bronchitis virus.

One-day-old specific-pathogen-free chicks were inoculated intranasally and intraocularly with infectious bronchitis virus (strain G). At days 1, 3, 5, 7, 10, and 14 postinfection, three birds were euthanatized, and the virus contents of both enteric tissues and some non-enteric tissues were assayed. Immunofluorescence and histopathological studies were also conducted. Six of 30 chicks died of nephritis between days 5-10 postinfection. Gross kidney lesions were the major pathological abnormalities. Inflammation was observed histologically in trachea, kidney, and rectum. High virus titers were found at various times in trachea, kidney, and all enteric tissues except for the jejunum. Relatively high titers of virus were still detectable at day 14 postinfection in the kidney, proventriculus, cecal tonsil, ileum, rectum, and bursa of Fabricius. Immunofluorescence staining showed viral antigens in enterocytes at the tips of villi in the ileum and rectum, and in the bursa. Viral antigens were also demonstrated in the epithelial cells of the trachea and in kidney tubules.

Animals↗
PubMedDate not supplied

Restriction endonuclease patterns of some European and American isolates of avian infectious laryngotracheitis virus.

Eleven isolates of infectious laryngotracheitis virus (nine European and two American) were compared by restriction endonuclease analysis of their DNA after radiolabeling with 32P. Digestion with KpnI gave identical cleavage patterns for all the European isolates, but the two American viruses (one field and one vaccine) showed some differences from them and from each other. In the case of the American vaccine strain, however, these differences were only minor. After BamHI digestion, only the American field isolate appeared to be different, whereas with HindIII, all 11 isolates were identical.

Animals↗
PubMedDate not supplied

Effects of information on adaptation to cesarean birth.

The effects of cesarean birth information given in childbirth preparation classes on maternal postpartum reactions to unplanned cesarean delivery were examined. An experimental group received comprehensive cesarean birth information as part of standard childbirth preparation classes. The control group received a standard childbirth preparation class curriculum that included limited cesarean birth information. The control group reported a slight decline in pain intensity from 1-2 days to 6 weeks postpartum, whereas the experimental group showed no change over time. No differences between the two groups were found in perception of the birth experience, physical distress, self-esteem, functional status, feelings about the baby, or quality of the marital relationship. The lack of substantial differences between the groups may be due to the normalizing effect of the high cesarean birth rate and greater attention given to this method of childbirth by expectant parents and childbirth educators.

Activities of Daily Living↗
PubMedDate not supplied

Failure of maternal antibodies to protect young turkey poults against challenge with turkey rhinotracheitis virus.

Groups of turkey poults with high levels of maternal antibodies (MA+) to turkey rhinotracheitis virus (TRTV) were challenged with virulent TRTV at 1, 5, and 10 days of age. A maternal antibody-free group (MA-) was also challenged at 1 day of age. Before each challenge, levels of maternal antibodies to TRTV were measured by enzyme-linked immunosorbent assay. Clinical signs were scored for each group. Unchallenged poults showed no signs. Respiratory signs in poults infected at 10 days of age resembled those seen in MA- birds infected at 1 day of age but both were more severe than in MA+ birds infected at 1 day of age, when the maternal antibodies were highest. However, overall, the presence of high levels of maternal antibodies did not prevent the development of clinical disease.

Aging↗