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Biomedical subjects

R C Jones

Publications and source records attributed to R C Jones.

At least 217 records · Page 12Linked to original sources

Morbidity of appendectomy in patients with acute salpingitis.

Diagnosis of right lower quadrant pain in a woman is frequently confusing. The course of 53 patients who had operation with a normal appendix and no other intra-abdominal pathology is compared with a group of 50 patients with a normal appendix and acute salpingitis. Appendectomies were performed in all cases and there was a lower mortality and morbidity rate in the group of patients with salpingitis. It is, therefore, concluded that appendectomy is a safe procedure in patients with acute salpingitis.

Acute Disease↗

The isolation and some biological properties of a variant avian infectious bronchitis virus.

A virus isolated from a respiratory disease in chickens was identified as infectious bronchitis virus (IBV). By serum neutralisation tests the virus was shown to be serologically distinct from the Massachusetts type but to possess a one-way relationship with the Connecticut type. Experimentally, it caused a relatively mild respiratory disease in baby chicks. Vaccination of young chicks with H-120 Massachusetts IBV vaccine afforded a high degree of protection against challenge with the isolate. Some problems relating to the isolation and classification of field strains of IBV are briefly discussed.

Animals↗

Inadequacy of steroids in the treatment of severe hemorrhagic shock.

Massive doses of methylprednisolone were given to dogs prior to severe, lethal, hemorrhagic shock. An untreated group of dogs subjected to hemorrhagic shock served as controls. No persistent significant differences were seen in cardiac output, mean arterial blood pressure, superior mesenteric artery flow, and survival. Calculated total peripheral resistance tended to be lower in the treated dogs and was significantly lower after reinfusion of shed blood. Pretreatment with methylprednisolone did not prevent plasma elevations of the lysosomal enzymes, cathepsin D and beta-glucuronidase. Stabilization of hepatic lysosomes in treated dogs subjected to hemorrhagic shock was not evident. The results failed to indicate significant salutary effects of methylprednisolone sodium succinate in this lethal hemorrhagic shock model.

Animals↗