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Biomedical subjects

R C Goodlin

Publications and source records attributed to R C Goodlin.

At least 37 records · Page 2Linked to original sources
PubMed1995

Do concepts of causes and prevention of cerebral palsy require revision?

OBJECTIVE: My purpose was to explore the criteria of The American College of Obstetricians and Gynecologists (Technical Bulletin No. 163) for perinatal asphyxia to be linked to subsequent cerebral palsy. STUDY DESIGN: Analysis of four cases of intrapartum fetal insults with subsequent cerebral palsy and a literature review are presented. RESULTS: All of the four cerebral palsy cases had sufficient intrapartum causes of cerebral palsy, yet none fulfilled The American College of Obstetricians and Gynecologists' linkage criteria. Complications in the cerebral palsy cases were as follows: maternal intrapartum cardiac arrest, fetal skull fracture with brain infarct, intrapartum fetal stroke, and a newborn delivered after uterine rupture with only central nervous system defects. There are no well-done laboratory or clinical studies that unequivocally support the "criteria" that umbilical artery pH must be < 7.00 or the requirements of Apgar score < 3, hypoxic-ischemic encephalopathy, and multiple organ dysfunction. Apparent exceptions to these criteria occur. CONCLUSIONS: The American College of Obstetricians and Gynecologists Technical Bulletin's criteria for cerebral palsy linkage and the role of parturition in cerebral palsy should be reevaluated. A rebirth of obstetric enthusiasm for cerebral palsy research, teaching, and treatment needs to occur.

Blood↗
PubMed1994

The neonate with unexpected acidemia.

We attempted to determine the etiology and clinical significance of unexpected acidemia in otherwise healthy neonates. A retrospective review was performed of the umbilical cord pH in 11,203 deliveries performed at Denver General Hospital, with an umbilical artery pH < 7.13 (3 SD below the mean) selected as the definition of neonatal acidemia. Among those neonates weighing > 2.5 kg with umbilical artery pH < 7.13, 76 were expected to have acidemia because of signs of severe fetal distress. There were 59 neonates with unexpected acidemia, having umbilical artery pH < 7.13, with no definite etiology found. In 96% of cases of unexpected acidemia, the neonates were discharged with their mothers, while 84% of the expected cases went home with their mothers. In excess of $880,000 was spent performing routine umbilical blood pH determinations without any apparent clinical or legal benefit. Routine umbilical blood gas studies on all neonates does not appear to be indicated for either clinical or legal reasons.

Acidosis↗